Bacterial and Eukaryotic Porins - Structure, Function, Mechanism
Published on 21. June 2005
Software
Other digital
382 pages
978-3-527-60387-9 (ISBN)
Description
This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice. For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function. With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.
Reviews / Votes
"...a scholarly research monograph on the biophysical aspects of porins...recommended for molecular and structural biologists working with porin proteins and academic libraries..." (E-STREAMS, May 2005) "This excellent book should be present in all laboratories...the information is extremely up-to-date and is supported by high-quality and highly original graphics." (International Microbiology, Vol.7, 2004)More details
Language
English
Place of publication
Weinheim
Germany
Target group
Professional and scholarly
College/higher education
Weight
10 gr
ISBN-13
978-3-527-60387-9 (9783527603879)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Person
Roland Benz (born 1943) studied Mathematics, Chemistry and Physics at the University of Wurzburg (Germany) before joining the group of Peter Lauger at Konstanz University, where he obtained his PhD in Biology and his habilitation in Biophysics. Recipient of a Heisenberg Fellowship of the German Research Society (DFG), he was a Visiting Professor at the State University of New York in 1980 and again in 1982, and at the University of British Columbia in Vancouver in 1984. Since 1986 he is full Professor of Biotechnology at the University of Wurzburg. His research is centered on the molecular basis of membrane transport in microorganisms and higher organisms, with a special interest into pore-forming peptides and proteins.
Content
Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR The Structures of General Porins Role of bacterial porins in antibiotic susceptibility of gram-negative bacteria Porins of the Outer Membrane of Pseudomonas aeruginosa Regulation of Bacterial Porin Function Reconstitution of General Diffusion Pores from Bacterial Outer Membranes OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins Drug Efflux and Protein Export through Channel-tunnels Structure-Function Relationships in Sugar-Specific Porins Role of the Carbohydrate-Specific Maltoporin in Substrate Uptake Functional Reconstitution of Specific Porins Energy-Coupled Outer Membrane Iron Transporters Structural and Functional Aspects of the Vitamin B12 Receptor BtuB Structure and Function of Mitochondrial Porins Mitochondrial Porins in Mammals: Insights Into Functional Roles From Mutant Mice and Cells Gene Family Expression and Multitopological Localization of Eukaryotic Porin/VDAC Function of the Outer Mitochondrial Membrane Pore (VDAC) in Intracellular Signalling