Iron-Containing Enzymes
Versatile Catalysts of Hydroxylation Reactions in Nature
1st Edition
Published on 4. August 2011
462 pages
978-1-84973-298-7 (ISBN)
Description
There are many mononuclear iron containing enzymes in nature that utilize molecular oxygen and transfer one or both oxygen atoms of O2 to substrates. These enzymes catalyze many processes including the biosynthesis of hormones, the metabolism of drugs, DNA and RNA base repair and, the biosynthesis of antibiotics. Therefore, mononuclear iron containing enzymes are important intermediates in bioprocesses and have great potential in the commercial biosynthesis of specific products since they often catalyze reactions regioselectively or stereospecifically. Understanding their mechanism and function is important and will assist in searches for commercial exploitation. In recent years, advances in experimental as well as theoretical methodologies have made it possible to study the mechanism and function of these enzymes and much information on their properties has been gained. This book highlighting recent developments in the field is, therefore, a timely addition to the literature and will interest a broad readership in the fields of biochemistry, inorganic chemistry and computational chemistry. The Editors, leaders in the field of nonheme and heme iron containing monoxygenases, have filled the book with topical review chapters by leaders in the various sub-disciplines.
More details
Edition
1. Auflage
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
ISBN-13
978-1-84973-298-7 (9781849732987)
DOI
10.1039/9781849732987
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Samuel P. de Visser | Devesh Kumar
Iron-Containing Enzymes
Versatile Catalysts of Hydroxylation Reactions in Nature
Book
09/2011
Royal Society of Chemistry
€173.50
Shipment within 3-4 weeks
Persons
Dr. Sam P. de Visser is based at the Manchester Interdisciplinary Biocenter and School of Chemical Engineering and Analytical Science in Manchester, UK. His research interests include the study of enzyme function and mechanism using theoretical chemistry techniques and the investigation of mononuclear and binuclear dimetal oxidants of substrate monoxygenation, dioxygenation and dehydrogenation. Dr Visser gained his M.Sc. and Ph.D from the University of Amsterdam in The Netherlands. His postdoctoral research was at King's College London and then the Hebrew University of Jerusalem. He has written several review articles and numerous research papers and has acted as a regular reviewer for numerous research journals. He also Guest Edited a special issue of the Journal of Physical Chemistry - A on "Sason Shaik Festschrift". He is a member of a number of scholarly societies and the winner of the Ramsay Memorial Fellowship of the Royal Netherlands Academy of Arts and Sciences (1997) and the Lise Meitner Minerva Junior Award from the Israel Chemical Society (2003). Dr. Devesh Kumar his based at the Max-Planck-Institut f (3)r Kohlenforschung, Germany. His research interests include studies of the reactivity of organic substrates with metalloenzymes or biomimetic catalysts and Simulations of intermolecular interactions in mesogens and biological molecules. Dr Kumar obtained is M.Sc. and Ph.D from Gorakhpur University in India. His postdoctoral research, before joining the The Max-Planck-Institut f (3)r Kohlenforschung, was at Nagarjuna University in India and The Hebrew University of Jerusalem. He has written several review articles and numerous research papers and has acted as a regular reviewer for numerous research journals. He has also delivered several important lectures and is a member of the Indian Biophysics Society. Devesh Kumar is Assistant Editor of Nanoscale Research Letters and has Guest Edited two special issues of the Journal of Physical Chemistry - A.
Content
Nonheme iron(IV)-oxo oxidants in enzymes: Spectroscopic properties and reactivity patterns;
Heme iron(IV)-oxo oxidants in enzymes: Spectroscopic properties and reactivity patterns;
Mechanism and function of taurine/ -ketoglutarate dioxygenase enzymes, an update;
Mechanism and function of cysteine dioxygenase enzymes;
Mechanism and function of heme peroxidase enzymes;
Mechanism and function of cytochrome P450 enzymes Biomimetic studies of mononuclear nonheme iron containing oxidants;
Biomimetic studies of mononuclear porphyrin containing oxidants;
Density functional calibration studies on iron-containing systems;
Density functional theory studies on isomerisation reactions catalyzed by cytochrome P450 enzymes Quantum mechanics/molecular mechanics studies of peroxidase enzymes;
Theoretical modelling of nonheme iron containing oxidants
Heme iron(IV)-oxo oxidants in enzymes: Spectroscopic properties and reactivity patterns;
Mechanism and function of taurine/ -ketoglutarate dioxygenase enzymes, an update;
Mechanism and function of cysteine dioxygenase enzymes;
Mechanism and function of heme peroxidase enzymes;
Mechanism and function of cytochrome P450 enzymes Biomimetic studies of mononuclear nonheme iron containing oxidants;
Biomimetic studies of mononuclear porphyrin containing oxidants;
Density functional calibration studies on iron-containing systems;
Density functional theory studies on isomerisation reactions catalyzed by cytochrome P450 enzymes Quantum mechanics/molecular mechanics studies of peroxidase enzymes;
Theoretical modelling of nonheme iron containing oxidants
