Ion Channel Gating and Mechanisms
Description
Ionic channels are key signaling molecules that support electrical communication throughout the body. As such, these channels are a central focus of active research as it relates to neuroscience, biomedical engineering, computational biology, biophysics, and drug discovery. This book is developed based on materials from a popular course on Ionic Channels of Excitable Membranes at Johns Hopkins University by late Dr. David T. Yue. The book introduces the quantitative framework including key topics from biophysics, stochastic processes, and mathematical models used to understand ion channel function. Development of these topics will provide a deep understanding of the interrelation of ionic channels to a broad range of biological and engineering fields.
Key Features:
- Textbook will feature work out problems and analogies
- Written and compiled by David Yue's lab members
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Persons
David Yue was a Professor in the Departments of Biomedical Engineering and Neuroscience at Johns Hopkins University. A renowned biophysicist, he was recognized for his pioneering research on voltage-gated calcium channels, and his profound passion for teaching and mentorship. Since his passing in 2015, David continues to be deeply missed by the many students and colleagues whose lives and careers were shaped by his brilliance and kindness.
Manu Ben Johny is an Assistant Professor in the Department of Physiology and Cellular Biophysics at Columbia University, focused on developing of precision molecular tools to treat ion channelopathies. He obtained his PhD from Johns Hopkins University working with Dr. David T. Yue.
Ivy Dick is currently an Associate Professor in the Department of Pharmacology and Physiology at the University of Maryland School of Medicine, studying voltage-gated calcium channels. She earned her PhD from Johns Hopkins University under the direction of Dr. David T. Yue.
Content
Preface
Acknowledgments
Author biographies
1 Hodgkin-Huxley view of ion channels
2 The big deal about single-channel information
3 Markovian gating as a linear system I
4 Markovian gating as a linear system II
5 Fluctuation analysis of ion-channel gating
6 Gating currents: an alternate view of channel operation
