Toxicology and Experimental Models

Introduction The Rational Interpretation of Species and Strain Differences in Toxicity for the Prediction of Risk to Man The rational interpretation of species and strain differences for the prediction of risk to man - Introduction The potential value of immunopathology in toxicity studies Lessons from studies in animals for the evaluation of human risk from teratogenic agents Genetic variability in man as a complicating factor in the extrapolation of toxicological data from animals The rational interpretation of species and strain differences in toxicity for the prediction of risk to man: Review and concluding remarks Chemical Interactions Resulting in Liver and Kidney Injury Ethanol potentiation of liver injury Potentiation of liver and kidney injury by ketones and ketogenic substances Biochemical mechanisms of acetaminophen (paracetamol) induced hepatic and renal toxicity The hepatotoxicity and nephrotoxicity of hexachlorobutadiene Modulation of nephrotoxicity by environmental chemicals Heme Synthesis and Degradation: Its Role in Predicting Drug Toxicity Heme synthesis and degradation: its role in predicting drug toxicity - Opening remarks Effects of drugs and chemicals on d-aminolevulinic acid synthase, the rate-limiting enzyme of heme synthesis Effects of drugs and metals on heme degradation by the heme oxygenase system Liver haem as a target for drug toxicity Toxic effects of metals on the synthesis and disposition of heme The heme biosynthetic pathway in the prediction of haloaromatic hydrocarbon toxicity Delayed Toxic Effects of Pre- and Perinatal Drug Exposure An overview on delayed toxic effects of pre- and perinatal drug exposure Improvements in the postnatal detection of central nervous system defects Maldevelopment of CNS induced by perinatal metabolic insults and possibilities of its regulation Altered postnatal development following intrauterine exposure to hormonally active chemicals Alcohol Intoxication and Withdrawal Alcohol intoxication and withdrawal: Introductory remarks The role of mitochondrial NADH reoxidation in the hepatic metabolism of ethanol: studies with perfused livers from ethanol and CCl4-treated rats Thanol and membrane cholesterol Suceptibility to ethanol of neurons in lateral vestibular, spinal trigeminal and lateral geniculate nuclei Dissociation of components of ethanol intoxication and tolerance Models of Experimental Peptic Ulcers and Therapeutic Agents Models of experimental peptic ulcers and therapeutic agents Possible roles of central catecholamines in regulation of gastric functions Duodenal ulcer and dopamine: new elements in pathogenesis and therapy Defensive mechanism in peptic ulcer and assessment of anti-ulcer agents Differential role of histamine in duodenal versus gastric experimental ulcer Can the mechanisms of aspirin-induced gastric mucosal injury be identified? Screening of anti-ulcer agents using experimental ulcer models Models and Quality Control of Laboratory Animals Introduction to models and quality control of laboratory animals Consideration of provision and characterization of animal models New animal models in pharmaceutical research Species variation in evaluation of safety of drugs in the developing animal Defined laboratory animals Quality control in diets - the attainable Problems and improvements in the development of good laboratory practice Index