DNA Repair and Replication
Published on 24. December 2004
368 pages
978-0-08-052242-5 (ISBN)
Description
DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.Selected Contents:
- Base Excision Repair
- Eukaryotic DNA Mismatch Repair
- Double Strand Break Repair
- Functions of DNA Polymerases
- Somatic Hypermutation: A Mutational Panacea
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12/2004
Academic Press
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Content
- Cover
- DNA Repair and Replication
- Copyright Page
- CONTENTS
- PREFACE
- Chapter 1. Base Excision Repair
- I. Introduction
- II. Types of Damage Repaired by BER
- III. DNA Glycosylases
- IV. Downstream BER Enzymes
- V. Mammalian BER
- VI. Roles of BER Enzymes in Other Processes
- References
- Chapter 2. Nucleotide Excision Repair in E. Coli and Man
- I. Introduction
- II. Damage Recognition
- III. Mechanism of Excision Repair
- IV. Transcription-Coupled Repair
- V. Repair of Chromatin
- VI. Conclusion
- References
- Chapter 3. Photolyase and Cryptochrome Blue-Light Photoreceptors
- I. Introduction
- II. Phylogenetics
- III. Structure of Photolyase
- IV. Reaction Mechanism of Photolyase
- V. (6-4) Photolyase
- VI. Cryptochrome
- VII. Conclusion
- References
- Chapter 4. Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage
- I. Introduction
- II. Overview of Biological Responses to DNA Damage
- III. Molecular Components for the Initiation of DNA Damage Responses
- IV. Apoptotic Effectors in DNA Damage Response
- V. DNA Repair Proteins in Damage Signaling
- VI. Alternative Models for the Temporal Coordination of DNA Damage Responses
- VII. Future Prospects
- References
- Chapter 5. Functions of DNA Polymerases
- I. DNA Polymerase Families
- II. Structures and Compositions of DNA Polymerases
- III. Functions of DNA Polymerases
- IV. Polymerases for DNA Repair
- V. Polymerases for Replicating Undamaged DNA
- VI. Polymerases for Sister Chromatid Cohesion
- VII. Mitochondrial DNA Replication.
- VIII. Polymerases for Replicating Damaged DNA.
- IX. Polymerases and Cell-Cycle Checkpoints
- X. Polymerases for Replication Restart and Homologous Recombination
- XI. Polymerases for DNA Mismatch Repair
- XII. Polymerases in the Development of the Immune System
- XIII. Biological Consequences of Polymerase Dysfunction
- XIV. Closing Comments
- References
- Chapter 6. Cellular Functions of DNA Polymerase and Rev1 Protein
- I. Introduction
- II. Enzymological Studies With Pol? and Rev1p
- III. Genetic Analysis
- IV. Processes Other than General Translesion Replication that Employ Pol and Rev1p
- V. Regulation of Pol? and Rev1p and Interactions with other Proteins
- VI. Conclusions and Speculations
- References
- Chapter 7. DNA Polymerases? and ?
- I. Historical Perspective
- II. Identification of RAD30 and its Orthologs
- III. Biochemical Properties of Pol? and Pol?
- IV. Translesion Synthesis by Pol? and Pol?
- V. Structure of the Catalytic Core of S. cerevisiae Pol?
- VI. Regulation and Localization of Pol? and Pol?
- VII. Mutations in Polc? in XP Variants
- VIII. Pols? and ? and the Polymerase Switch: Interactions with PCNA and Rev1
- IX. Protection from Cellular Effects of DNA Damage
- X. Roles of Pol? and Pol? in Somatic Hypermutation
- References
- Chapter 8. Properties and Functions of Escherichia Coli : Pol IV and Pol V
- I. DNA Pol IV, the dinB Gene Product
- II. DNA Polymerase V, the umuDC Gene Product
- References
- Chapter 9. Mammalian Pol ?: Regulation of Its Expression and Lesion Substrates
- I. Structures of the Genes and Proteins
- II. Enzymatic Properties of Pol?
- III. Possible Mechanisms of TLS by Pol? In Vivo
- References
- Chapter 10. DNA Postreplication Repair Modulated by Ubiquitination and Sumoylation
- I. Introduction
- II. DNA Postreplication Repair Prokaryotes
- III. DNA Postreplication Repair in Eukaryotes
- IV. Ubiquitination
- V. Protein Conjugation in PRR
- VI. Postreplication Repair via Covalent Modifications of PCNA
- VII. Functional Conservation of Eukaryotic Postreplication Repair
- VIII. Future Directions
- IX. Conclusions
- References
- Chapter 11. Somatic Hypermutation: A Mutational Panacea
- I. Generation of Antibody Diversity
- II. Somatic Hypermutation
- III. Apobec Protein Family
- IV. Biochemical Perspective
- References
- Author Index
- Subject Index
