Myopathies, An Issue of Rheumatic Disease Clinics
Published on 28. May 2011
192 pages
978-1-4557-1242-7 (ISBN)
Description
This issue of Rheumatic Disease Clinics provides important updates in myopathies. The following essential topics are covered. Clinical features, pathophysiology, and treatment of polymyositis and dermatomyositis; inclusion body myositis; metabolic myopathies; drug-induced myopathies; muscular dystrophies and neurologic diseases; laboratory testing and imaging; electrophysiological studies; metabolic and genetic testing; and pathology.
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05/2011
Saunders
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Content
- Front Cover
- Contributors
- Contents
- Preface: Myopathies
- Chapter 1. Polymyositis, Dermatomyositis, and Autoimmune Necrotizing Myopathy: Clinical Features
- EPIDEMIOLOGY
- DEFINITION
- MUSCULAR MANIFESTATIONS
- EXTRAMUSCULAR MANIFESTATIONS
- JOINT MANIFESTATIONS
- DERMATOLOGIC MANIFESTATIONS
- CARDIAC MANIFESTATIONS
- PULMONARY MANIFESTATIONS
- GASTROINTESTINAL MANIFESTATIONS
- MUSCLE BIOPSY
- LABORATORY TESTING
- ANTIBODIES
- STUDIES/IMAGING
- DIFFERENTIAL DIAGNOSIS
- AUTOIMMUNE NECROTIZING MYOPATHY AND THE STATIN CONNECTION
- SUMMARY
- REFERENCES
- Chapter 2. Polymyositis and Dermatomyositis: Pathophysiology
- ADAPTIVE IMMUNE MECHANISMS
- INNATE AND NONIMMUNE MECHANISMS
- SUMMARY
- REFERENCES
- Chapter 3. Inclusion Body Myositis: Diagnosis, Pathogenesis, and Treatment Options
- EPIDEMIOLOGY
- CLINICAL FEATURES
- LABORATORY FINDINGS
- ELECTRODIAGNOSTIC FINDINGS
- DIAGNOSIS
- DIFFERENTIAL DIAGNOSIS
- HISTOPATHOLOGY
- PATHOGENESIS
- TREATMENT
- SUMMARY
- REFERENCES
- Chapter 4. Paraneoplastic Muscle Disease
- DERMATOMYOSITIS AND POLYMYOSITIS
- NECROTIZING MYOPATHY
- EATON-LAMBERT SYNDROME
- MG
- STIFF PERSON SYNDROME
- SUMMARY
- REFERENCES
- Chapter 5. Metabolic Myopathies: Clinical Features and Diagnostic Approach
- DISORDERS OF GLYCOGEN METABOLISM (MUSCLE GLYCOGENOSES)
- SUMMARY: APPROACH TO THE DIAGNOSIS OF METABOLIC MYOPATHIES
- ACKNOWLEDGMENTS
- REFERENCES
- Chapter 6. Drugs Causing Muscle Disease
- DRUGS FOR CARDIOVASCULAR DISEASE
- RHEUMATOLOGIC DRUGS
- INFECTIOUS DISEASE DRUGS
- ONCOLOGY DRUGS
- GASTROINTESTINAL DRUGS
- NEUROLOGIC AND PSYCHIATRIC DRUGS
- SUMMARY
- REFERENCES
- Chapter 7. Muscular Dystrophies and Neurologic Diseases that Present as Myopathy
- DIAGNOSTIC EVALUATION
- CLINICAL SYNDROMES
- TREATMENT
- SUMMARY
- REFERENCES
- Chapter 8. Imaging of Skeletal Muscle
- REFERENCES
- Chapter 9. A Primer on Electrophysiologic Studies in Myopathy
- PURPOSE AND LIMITATIONS
- PRINCIPLES OF MUSCLE PHYSIOLOGY
- ELECTROMYOGRAPHY
- NERVE CONDUCTION STUDIES
- REPETITIVE STIMULATION
- CASE PRESENTATION
- SUMMARY
- REFERENCES
- Chapter 10. Molecular Diagnosis of Myopathies
- MODES OF INHERITANCE
- LABORATORY INVESTIGATIONS
- DNA AND RNA INVESTIGATIONS
- DETECTION OF KNOWN MUTANTS
- INDICATIONS FOR GENETIC TESTING IN NEUROMUSCULAR DISEASE
- FUTURE PERSPECTIVES
- REFERENCES
- Chapter 11. Essential Muscle Pathology for the Rheumatologist
- INTRODUCTION TO MUSCLE BIOPSY AND BASIC HISTOPATHOLOGIC CHANGES IN SKELETAL MUSCLE
- METABOLIC MYOPATHIES
- IDIOPATHIC INFLAMMATORY MYOPATHIES
- DRUG-INDUCED MYOPATHIES
- SUMMARY
- REFERENCES
- Index
