Abbreviations

1 Å =0.1 nm aa-tRNA aminoacyl-tRNA AAV adeno-associated virus ABC ATP-binding cassette Acetyl CoA acetyl coenzyme A AcNPV Autographa californica nuclear polyhedrosis virus ACRS amplification-created restriction sites ACTH adrenocorticotropic hormone ADA adenosine deaminase ADEPT antibody-directed enzyme prodrug therapy ADME-T absorption, distribution, metabolism, excretion, and toxicity ADP adenosine diphosphate ADRs adverse drug reactions AEC aminoethylcysteine AFLP amplified fragment length polymorphism AFM atomic force microscope AIDS acquired immunodeficiency syndrome ALS amyotrophic lateral sclerosis AMP adenosine monophosphate AMPA a-amino-3-hydroxyl-5-methyl-4-isoxazol-propionate Ampr ampicillin resistance gene AMV avian myeloblastosis virus ANN artificial neural network AO acridine orange AOX1 alcohol oxidase 1 APC anaphase-promoting complex ApoB100 apolipoprotein B100 ApoE apolipoprotein E APP amyloid precursor protein ARMS amplification refractory mutation system ARS autonomously replicating sequence ATP adenosine triphosphate att attachment site BAC bacterial artificial chromosome bcl2 B-cell leukemia lymphoma 2 (protein protecting against apoptosis) BfArM German Bundesinstitut für Arzneimittel und Medizinprodukte ß-Gal ß-galactosidase BHK-21 baby hamster kidney cells BLA biologics licence application BLAST Basic Local Alignment Search Tool BMP bone morphogenetic proteins bp base pairs BrdU bromodeoxyuridine CA correspondence analysis CAD coronary artery disease CaM-Kinase Ca2+/calmodulin-dependent protein kinase cAMP cyclic AMP cap AAV gene mediating encapsulation CARS coherent anti-Raman scattering CAT Committee for Advanced Therapies CBER Center for Biologics Evaluation and Research CC chromatin remodeling complex CCD charge-coupled device CDER Center for Drug Evaluation and Research CDK cyclin-dependent kinase cDNA copy DNA CDR complementarity-determining region CDRH Center for Devices and Radiological Health CEO chief executive officer CFP cyan fluorescent protein CFTR cystic fibrosis transmembrane regulator CGAP Cancer Genome Anatomy Project CGH comparative genome hybridization CHMP Committee for Medicinal Products for Human Use CHO Chinese hamster ovary CIP calf intestinal phosphatase CML chronic myeloid leukemia CMN Corynebacterium-Mycobacterium-Nocardia group CaMV cauliflower mosaic virus CMV cytomegalovirus CNS central nervous system COMP Committee for Orphan Medicinal Products COS-1 simian cell line, CV-1, transformed by origin-defective mutant of SV40 cpDNA chloroplast DNA CPMV cowpea mosaic virus cPPT-sequence central polypurine tract - regulatory element in lentiviral vectors that facilitates double strand synthesis and the nuclear import of the pre-integration complex CSF colony-stimulating factor CSO contract service organization CTAB cetyltrimethylammonium bromide CVM Center for Veterinary Medicine CVMP Committee for Medicinal Products for Veterinary Use 2D two-dimensional Da Dalton DAG diacylglycerol DAPI 4,6-diamidino-2-phenylindole dATP deoxyadenosine triphosphate DBD DNA-binding domain DAC divide-and-conquer strategy DD differential display DDBJ DNA Data Bank of Japan ddNTP dideoxynucleotide triphosphate DEAE diethylaminoethyl dHPLC denaturing HPLC DIC differential interference contrast DIP Database of Interacting Proteins DNA deoxyribonucleic acid DNAse deoxyribonuclease dNTP deoxynucleoside triphosphate Dox doxycycline ds diabodies disulfide-stabilized diabodies dsDNA double-stranded DNA dsFv-fragment disulfide-stabilized Fv fragment dsRNA double-stranded RNA DtxR diphtheria toxin repressor Ebola-Z envelope protein of the Ebola-Zaire virus, which has a high affinity to lung epithelial cells EC50 effective concentration, the dose or concentration that produces a 50% effect in the test population within a specified time ECD electron capture dissociation EDTA ethylenediaminetetraacetic acid ee enantiomeric excess EF2 elongation factor 2 EF-Tu elongation factor Tu EGF epidermal growth factor EGFP enhanced green fluorescent protein EGTA ethylene glycol bis(2-aminoethyl)tetraacetic acid EIAV equine infectious anemia virus ELISA enzyme-linked immunosorbent assay EM electron microscope EMA European Medicines Agency EMBL European Molecular Biology Laboratory EMCV encephalomyocarditis...