Calcium
The Grand-Master Cell Signaler
1st Edition
Published on 1. January 2001
247 pages
978-0-660-18991-8 (ISBN)
Description
This unique book has an exciting story to tell about Ca2+, the versatile Master Cell Signaler whose influence reaches into all corners of the cell and controls cell proliferation, differentiation, cell functions too numerous to list here, and even cell death. The book begins nearly 4 billion years ago with the emergence of life on the newborn Earth. One of the great turning points in the history of life on Earth, The Great Ca2+-Driven Eukaryotic Revolution, happened about 2 billion years later when Ca2+ was converted from a dangerous killer that had to be kept out of cells into the versatile Grand Master of cell signalers. It was this revolutionary conversion that enabled the development of eukaryotic cells from which came animals with shells, internal and external skeletons, muscles and brains, and, of course, the plants. The reader will be taken on a tour of tissues chosen to best show three (proliferator, differentiator, killer) of Ca2+'s many faces.
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01/2001
Canadian Science Publishing (NRC Research Press)
€95.52
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Content
- Intro
- Cover page
- Publishing information
- Title page
- Copyright
- Contents
- Abstract
- Résumé
- Introduction
- References
- 1. Cell Cycles and Checkpoints
- The G¹ buildup: getting ready for chromosome replication
- A checkpoint to pass
- The S phase: replicating the chromosomes - a daunting task
- Mitosis and the birth of two new cells
- References
- 2. Calcium - A Cell Cycle Driver
- The cycle-driving Ca²+ signals: a quick preview
- Ca²+ and starting the cycle
- Ca²+ and the G¹-S transition
- Ca²+ in mitosis
- References
- 3. Calcium and Keratinocyte Diffpoptosis
- Stem cells and cell stacks
- Ca²+ gradient
- What triggers diffpoptosis?
- Ca²+ and diffpoptosis in the unreal world of the culture dish
- Ca²+ and diffpoptosis in the real world of the skin
- The first step: from basal cell to spinous cell
- From spinous cell to granular cell: CaRs and upward to the head of the Ca²+ gradient
- The final push to cornification and oblivion
- Summary
- Cancerous keratinocytes
- On the road to malignancy
- The end of the road: malignancy
- A farewell to the skin
- References
- 4. Calcium and Colon Cell Diffpoptosis
- Colon crypts, stem cells and a cellular escalator
- Ca²+ and the control of colon cell proliferation, differentiation, and apoptosis
- Integrins, ILK, catenins, and proliferation
- Ca²+, E-cadherins, APC, and diffpoptosis
- Colon cancer
- The beginning of the road to cancer - aberrant crypts, polyps, and a loss of Ca²+ control
- The end of the road - a lucky winning clone and colon carcinoma
- References
- 5. Calcium and Neurons
- Intercellular Ca²+ waves and signaling networks
- Presynaptic Ca²+ signaling and short-term plasticity
- Postsynaptic Ca²+ signaling and long-term plasticity
- Calcium and neurotransmitter release
- Ca²+ and neuronal cell death
- References
- 6. But What About Ca²+ and Plants?
- Ca²+ and blowing in the wind
- Calcium and light
- Cold, drought, and Ca²+
- Ca²+ as a driver of growth and proliferation
- Conclusion
- References
- 7. Summary
- Index
