Intraoperative Radiotherapy for Breast Cancer
2nd Edition
Published on 10. July 2016
81 pages
978-3-8374-5522-9 (ISBN)
Description
Intraoperative radiotherapy (IORT), as a method in the subspecialty of interventional radiation oncology, is one of the most dynamically growing fields in oncology. During the last decade, the number of centers offering IORT to patients has rapidly increased. There are more than 300 active IORT centers worldwide. This interest has mainly been stimulated by the clinical benefits of IORT in breast cancer.
The 2nd edition of this handbook includes the basics of the IORT principles, a detailed description of techniques for IORT and a review of ongoing trials showing the benefits of this method in the treatment of breast cancer.
More details
Content
- Intro
- Authors
- Contents
- 1. Introduction
- 1.1. References
- 2. The tumor bed in breast cancer - definition and relevance
- 2.1. Definition and relevance
- 2.1.1. References
- 2.2. Rationale for PBI
- 2.2.1. References
- 2.3. Historic and ongoing PBI trials
- 2.3.1. References
- 3. Radiobiological aspects of IORT in breast cancer
- 3.1. Dose response for tumor cells and normal tissue
- 3.2. Basic radiobiological factors
- 3.2.1. The L-Q model
- 3.2.2. Extrapolation to high single doses
- 4. Indications for IORT in breast cancer
- 4.1. IORT as a boost
- 4.2. IORT as single treatment (i.e. partial breast irradiation)
- 4.3. References
- 5. IORT with 50 kV X-rays
- 5.1. Physical and technical aspects
- 5.1.1. INTRABEAM® system
- 5.1.2. Quality assurance
- 5.1.3. Workflow
- 5.1.4. Radiation protection
- 5.2. Surgical aspects
- 5.3. Radiotherapeutic aspects of low-KV IORT
- 5.3.1. References
- 5.4. IORT as a boost - clinical results
- 5.4.1. Acute toxicity
- 5.4.2. Late toxicity
- 5.4.3. Postoperative seroma formation
- 5.4.4. Influence of the interval between IORT and WBRT on late toxicity
- 5.4.5. The first five years of experience with a novel approach: Toxicity
- 5.4.6. The first five years of experience with a novel approach: Survival and local control
- 5.4.7. Quality of Life
- 5.4.8. Conclusion
- 5.4.9. References
- 5.5. Intraoperative radiotherapy for breast cancer - The TARGIT trial
- 5.5.1. Preliminary results of the TARGIT trial
- 5.5.2. References
- 5.6. Updated results of the TARGIT A trial
- 5.6.1. References
- 5.7. TARGIT-E (lderly) trial
- 5.7.1. Study design
- 5.7.2. References
- 5.8. The history of the development of the INTRABEAM® system
- 5.8.1. References
- 6. IORT with linear accelerators
- 6.1. IOERT methods
- 6.1.1. Target volume and design of an IOERT boost
- 6.2. Treatment concepts: intraoperative boost (BIOBoost versus full-dose IOERT
- 6.3. Clinical evidence
- 6.3.1. Boost concept
- 6.3.2. Sole IOERT concept
- 6.3.3. Toxicity / late reactions / cosmesis
- 6.4. IOERT during nipplesparing mastectomy
- 6.5. Ongoing trials
- 6.6. Summary
- 6.7. References
- Index
