Molecular Aspects of Animal Development

Contributors to Volume IIIPrefaceContents of Previous VolumesChapter 1 Molecular Events During Oocyte Maturation I. Introduction II. The Induction of Maturation III. Morphological Events of Maturation and Their Relationship to Early Development IV. Macromolecular Synthesis during Maturation V. Characterization of Hormone-Oocyte Interactions in the Induction of Maturation VI. Concluding Comments ReferencesChapter 2 Transcriptional Patterns in Early Mammalian Development I. General Introduction II. Onset of Gene Activity in Preimplantation Mammalian Embryos III. RNA Containing Poly(A) Sequences in Preimplantation Rabbit Embryos IV. Complexity of Transcription in Developing Mammals V. Mechanisms of Transcriptional Control VI. Relationship of Transcriptional Changes to the General Biochemistry of the Preimplantation Embryo VII. Concluding Remarks ReferencesChapter 3 Occurrence and Developmental Significance of Gene Amplification I. Introduction II. Gene Amplification Versus Gene Reiteration III. Occurrence of Gene Amplification IV. Visualization of Gene Amplification V. Possible Mechanisms of Gene Amplification VI. Theories on Developmental Significance VII. Summary and Concluding Remarks ReferencesChapter 4 The Injection of RNA into Living Cells: The Use of Frog Oocytes for the Assay of mRNA and the Study of the Control of Gene Expression I. Introduction II. The Translation and Assay of mRNA's III. Quantitative Studies: The Efficiency of Translation of Injected mRNA IV. The Fidelity of Translation of Injected mRNA's V. The Specificity of the Translational Machinery of the Oocyte VI. The Post-Translational Modification of Messenger Products VII. mRNA Injection as a Means for Analyzing the Translational Systems of the Living Cell VIII. Translation of mRNA-Precursor Molecules ReferencesChapter 5 Post-Transcriptional Control of Protein Synthesis I. Introduction II. Evidence for Translational Control of Protein Synthesis in Bacteria III. Evidence for Post-Transcriptional Control of Protein Synthesis in Animal Cells IV. Concluding Remarks ReferencesChapter 6 The Control of Isoenzyme Patterns in Development I. Introduction II. Isoenzyme Biochemistry: A General Introduction III. Isoenzyme Distribution IV. Mechanisms of Control of Isoenzyme Expression During Development V. Concluding Remarks ReferencesChapter 7 Substances with Morphogenetic Activity in Differentiation of Vertebrates I. Introduction II. Determination, Differentiation, and Competence III. Evidence for the Existence of Special Morphogenetic Factors IV. Chemical Properties, Biological Activity, and Mechanism of Action of Morphogenetic Substances Effective in Early Embryogenesis V. Induction and Determination in Normogenesis of Amphibian Embryos VI. Stimulation of Hematopoiesis VII. Nerve Growth Stimulating and Epithelial Growth Stimulating Factors VIII. Concluding Remarks ReferencesChapter 8 Protein Nutrition in Growth Regulation during Early Development I. Introduction II. The Requirement of Embryos for Nutrient Protein III. The Requirement of Embryos for Specific Nutrient Proteins IV. Nutrient Protein Complementation V. Quantitative Analysis of Protein Utilization VI. Protein Deprivation during Early Development ReferencesChapter 9 Mitochondrial Differentiation during Animal Development I. Introduction II. Structure of Mitochondria III. Enzyme Content of Mitochondria IV. Mitochondrial Differentiation V. Concluding Statement ReferencesChapter 10 Occurrence and Possible Functions of Mitochondrial DNA in Animal Development I. Introduction II. Cytoplasmic DNA III. Replication and Stability of mt DNA IV. Transcription of mt DNA V. Mitochondrial Protein Synthesis VI.