Autoimmune Disorders
Description
Comprehensive resource on the science of autoimmune disorders, covering causes, treatment, prevention, and the latest research in the field
Autoimmune Disorders is an authoritative reference on the science of autoimmune disorders, covering their causes, including infections, vaccine adjuvants, environmental stimuli, and silicone implants, the latest research on the genetics, epigenetics, and immunology of autoimmunity, predictive markers, therapeutic approaches for treatment and prevention, and suggestions for future research directions.
This book explores the intricate connections between adjuvants and autoimmune responses, focusing on the emergence of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA syndrome), as well as autoimmune connections in areas such as chronic fatigue syndrome, autoantibodies targeting the autonomic system, and small fiber neuropathy. The authors emphasize the profound impact of vaccines on public health, underscoring that their benefits far outweigh potential side effects and exploring the historical context of adjuvants in vaccine development. From tattoos to environmental factors, each chapter adds a unique thread to the tapestry of adjuvants, autoimmune responses, and their interactions.
Sample topics covered in Autoimmune Disorders include:
- Food additives and dental implants as a trigger of autoimmunity and increased risk of ASIA syndrome as a result of the chemical and social factors
- Sustained immune activation in ASIA syndrome as a bridge to lymphomagenesis and how immune checkpoints, metals, and bisphenol connect to autoimmunity
- Postural Orthostatic Tachycardia syndrome (POTS), Sick Building syndrome, and Gulf War syndrome (GWS) as parts of ASIA syndrome
- Sarcoidosis and Sjögren's syndrome as a proof of concept of hyperstimulation syndrome
Autoimmune Disorders is an essential reference on the subject for academics, specialized postgraduate students, and practicing professionals seeking to improve integrated research strategies and foster a deeper understanding of the complex relationship between immunology, public health, and individual well-being.
Abdulla Watad is a specialist in Internal Medicine and Rheumatology at the Sheba Medical Center affiliated with the Tel Aviv University in Israel and a visiting researcher in rheumatology at Leeds University, UK.
Nicola Luigi Bragazzi, MD, PhD, is a specialist in public health, biophysics, and immunology, and is included in the ISI/Clarivate 2023 list of Highly Cited Researchers, as one of the 1% of the world's top influential researchers and scientists.
Yehuda Shoenfeld is a leader in the field of autoimmunity and founder and head of the Zabludowicz Center for Autoimmune Diseases in the Sheba Medical Center. He is affiliated with the Reichman University, Herzliya, Israel. His h-index is over 130 and he is an author of over 2000 scientific articles and many textbooks in autoimmunity.
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Abdulla Watad is a specialist in Internal Medicine and Rheumatology at the Sheba Medical Center affiliated with the Tel Aviv University in Israel and a visiting researcher in rheumatology at Leeds University, UK.
Nicola Luigi Bragazzi, MD, PhD, is a specialist in public health, biophysics, and immunology, and is included in the ISI/Clarivate 2023 list of Highly Cited Researchers, as one of the 1% of the world's top influential researchers and scientists.
Yehuda Shoenfeld is a leader in the field of autoimmunity and founder and head of the Zabludowicz Center for Autoimmune Diseases in the Sheba Medical Center. He is affiliated with the Reichman University, Herzliya, Israel. His h-index is over 130 and he is an author of over 2000 scientific articles and many textbooks in autoimmunity.
Content
List of Contributors vii
Introduction xiii
Abdulla Watad, Nicola Luigi Bragazzi, and Yehuda Sheonfeld
1 Hyperstimulation of the Immune System 1
Hadas Hodadov and Abdulla Watad
2 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA): Genetics, Immunization, and Autoimmunity 7
Carlo Perricone, Elena Bartoloni Bocci, and Roberto Gerli
3 Vaccine Adjuvants: History, Role, Mechanisms of Action, and Side Effects 15
Nicola Luigi Bragazzi, Abdulla Watad, and Yehuda Shoenfeld
4 Commonly Used Food Additives Are Nutritional Adjuvants in ASIA Syndrome 29
Aaron Lerner and Carina Benzvi
5 Silicone Implant Incompatibility Syndrome 51
Vânia Borba and Yehuda Shoenfeld
7 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA or Shoenfeld's Syndrome) Due to Polypropylene Mesh Implants 67
Jan Willem Cohen Tervaert and Mohammed Osman
8 Vaccines, Vaccinosis, and Autoimmunity 85
Nicola Luigi Bragazzi, Abdulla Watad, and Yehuda Shoenfeld
9 Sustained Immune Activation in ASIA Syndrome - A Bridge to Lymphomagenesis 91
Dana Butnaru
10 Chronic Fatigue Syndrome 107
Kassem Sharif
11 Autoantibodies and Autonomic Nervous System 117
Iana Leineman, Varvara Ryabkova, and Natalia Gavrilova
12 Postural Orthostatic Tachycardia Syndrome (POTS) as a Part of ASIA Syndrome 129
Paula David
6 Silicone Breast Implants (SBIs) and Autoimmune Dysautonomya 63
Gilad Halpert, Abdulla Watad, Howard Amital, and Yehuda Shoenfeld
13 Role of the Small-fiber Neuropathy in the Pathogenesis of ASIA Syndrome 137
N. Gavrilova, E. Kamaeva, M. Lukashenko, and L. Soprun
14 Tattoo as a Possible Trigger for Autoimmune Syndrome Induced by Adjuvants 147
Paula David
15 The Sick Building Syndrome as a Part of the Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvant 155
Asher Pardo and Eitan Israeli
22 Sjögren's Syndrome as a Proof of Concept of the Hyperstimulation Syndrome 265
Vânia Borba and Yehuda Shoenfeld
23 Gluteal Biopolymer Injections as a Case of ASIA Syndrome 283
Rojas-Villarraga Adriana, María Alejandra Martínez-Ceballos, Uribe Rosa, and Montealegre Giovanni
16 Gulf War Syndrome (GWS) and ASIA Syndrome 167
Efrosiniia Talalai
17 Vaccinations in Patients with Autoimmune Diseases 181
Isa Seida and Naim Mahroum
18 Autoimmune Phenomena in Cancer Patients Treated with Immune Checkpoint Inhibitors 191
Milena Tocut, Michael Ehrenfeld, and Gisele Zandman-Goddard
19 Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity 201
Kassem Sharif and Howard Amital
20 The Role of Bisphenol A in ASIA Syndrome 225
Zora Lazurova
21 Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants: Is There a Connection? 247
Anna Malkova, Yulia Zinchenko, Anna Starshinova, Igor Kudryavtsev, Piotr Yablonskiy, and Yehuda Shoenfeld
24 The Chemical and Social Landscape of the Modern World and Increased Risk of ASIA 305
Albert Pinhasov, Elena Shmerkin, and Michael Kirby
25 Oil Injections and ASIA Syndrome 323
Olga Vera-Lastra, Alberto Ordinola-Navarro, Abihai Lucas Hernández, Gabriela Medina, María P. Cruz-Domínguez, Gabriel M. Ramírez, and Luis J. Jara
26 Metals in Dental Implants as a Trigger of Autoimmunity 337
Arad Dotan and Yehuda Shoenfeld
27 Conclusions: State of the Art and Prospects 341
Abdulla Watad, Nicola Luigi Bragazzi, and Yehuda Shoenfeld
Index 345
List of Contributors
- Rojas-Villarraga Adriana
- Research Institute
- Fundación Universitaria de Ciencias de la Salud (FUCS)
- Bogotá
- Colombia
- María Alejandra Martínez-Ceballos
- Fundación Oftalmológica Nacional
- Bogotá
- Colombia
- School of Medicine and Health Sciences
- Universidad del Rosario
- Bogotá
- Colombia
- Howard Amital
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Sackler Faculty of Medicine
- Tel Aviv University
- Tel Aviv
- Israel
- Department of Internal Medicine 'B'
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Carina Benzvi
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Elena Bartoloni Bocci
- Reumatologia
- Dipartimento di Medicina e Chirurgia
- Università di Perugia
- Perugia
- Italy
- Vânia Borba
- Internal Medicine Departmente
- Rehaklik Dussnang AG
- Dussnang
- Thurgau
- Switzerland
- Nicola Luigi Bragazzi
- Laboratory for Industrial and Applied Mathematics (LIAM)
- Department of Mathematics and Statistics
- York University
- Toronto
- Canada
- Postgraduate School of Public Health
- Department of Health Sciences (DISSAL)
- University of Genoa
- Genoa
- Italy
- Dana Butnaru
- Department of Clinical Immunology
- Hospital Clínico San Carlos
- Complutense University of Madrid
- Madrid
- Spain
- María P. Cruz-Domínguez
- Internal Medicine Department
- Unidad Médica de Alta Especiad
- Hospital de Especialidades
- "Dr. Antonio Fraga Mouret"
- Centro Médico Nacional
- "La Raza". Instituto Mexicano del Seguro Social
- México City
- México
- Internal Medicine Department
- División de Estudios de Posgrado
- Facultad de Medicina
- Universidad Nacional Autónoma de México
- México City
- México
- Paula David
- Department of Internal Medicine 'B'
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Arad Dotan
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Sackler Faculty of Medicine
- Tel Aviv University
- Tel Aviv
- Israel
- Michael Ehrenfeld
- Sackler Faculty of Medicine
- Tel Aviv University
- Tel Aviv
- Israel
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Natalia Gavrilova
- Federal State Budget Educational Institution of Higher Education "St. Petersburg State University"
- University Emb.
- 7-9
- Saint Petersburg
- Russia
- St Petersburg State University Hospital
- Saint Petersburg
- Russia
- Roberto Gerli
- Reumatologia
- Dipartimento di Medicina e Chirurgia
- Università di Perugia
- Perugia
- Italy
- Montealegre Giovanni
- Fundación Universitaria de Ciencias de la Salud (FUCS)
- Hospital San José
- Bogotá
- Colombia
- Gilad Halpert
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Department of Molecular Biology
- Ariel University
- Ariel
- Israel
- Abihai Lucas Hernández
- Internal Medicine Department
- Unidad Médica de Alta Especiad
- Hospital de Especialidades
- "Dr. Antonio Fraga Mouret"
- Centro Médico Nacional
- "La Raza". Instituto Mexicano del Seguro Social
- México City
- México
- Hadas Hodadov
- Sackler Faculty of Medicine
- Tel Aviv University
- Tel Aviv
- Israel
- Eitan Israeli
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Luis J. Jara
- Research Division
- Instituto Nacional de Rehabilitación
- Mexico City
- México
- E. Kamaeva
- Federal State Budget Educational Institution of Higher Education "St. Petersburg State University"
- University Emb.
- 7-9
- Saint Petersburg
- Russia
- Michael Kirby
- Department of Molecular Biology and Adelson School of Medicine
- Ariel University
- Ariel
- Israel
- Igor Kudryavtsev
- Almazov National Medical Research Centre
- The Research Department
- Saint Petersburg
- Russia
- Department of Immunology
- Institution of Experimental Medicine
- Petersburg State University
- Saint Petersburg
- Russia
- Zora Lazurova
- 4th Department of Internal Medicine
- Pavol Jozef Safárik University
- Kosice
- Slovakia
- Iana Leineman
- Department of Therapy
- Rheumatology
- Examination of Temporary Disability and Quality of Medical Care Named After E.E. Eichwald
- North-Western State Medical University Named After I.I.Mechnikov
- Saint Petersburg
- Russia
- Aaron Lerner
- Zabludowicz Center for Autoimmune Diseases
- Sheba Medical Center
- Tel-Hashomer
- Israel
- Campus Ariel
- Ariel University
- Ariel
- Israel
- M. Lukashenko
- Federal State Budget Educational Institution of Higher Education "St. Petersburg State University"
- University Emb.
- 7-9
- Saint Petersburg
- Russia
- Naim Mahroum
- International School of Medicine
- Istanbul Medipol University
- Istanbul
- Turkey
- Anna Malkova
- Laboratory of the Mosaic of Autoimmunity
- St. Petersburg State University
- Saint Petersburg
- Russia
- Gabriela Medina
- Internal Medicine Department
- Unidad Médica de Alta Especiad
- Hospital de Especialidades
- "Dr. Antonio Fraga Mouret"
- Centro Médico Nacional
- "La Raza". Instituto Mexicano del Seguro Social
- México City
- México
- Internal Medicine Department
- División de Estudios de Posgrado
- Facultad de Medicina
- Universidad Nacional Autónoma de México
- México City
- México
- Alberto Ordinola-Navarro
- Internal Medicine Department
- Unidad Médica de Alta Especiad
- Hospital de Especialidades
- "Dr. Antonio Fraga Mouret"
- Centro Médico Nacional
- "La Raza". Instituto Mexicano del Seguro Social
- México City
- México
- Internal Medicine Department
- División de Estudios de Posgrado
- Facultad de Medicina
- Universidad Nacional Autónoma de México
- México City
- México
- Mohammed Osman
- Division of Rheumatology
- Department of Medicine
- University of Alberta
- Edmonton
- Alberta
- Canada
- Asher Pardo
- Department of Occupational and Environmental Health
- School of Public Health - Tel Aviv University and the Institute for Occupational Safety and Hygiene
- Tel Aviv
- Israel
- Carlo Perricone
- Reumatologia
- Dipartimento di Medicina e Chirurgia
- Università di Perugia
- Perugia
- Italy
- Albert Pinhasov
- Department of Molecular Biology and Adelson School of Medicine
- Ariel University
- Ariel
- Israel
- Gabriel M. Ramírez
- Rheumatology Department
- Hospital General de México
- "Dr. Eduardo Liceaga"
- México City
- México
- Uribe Rosa
- Antioquia's Clinic
- Itagüí
- Colombia
- Varvara Ryabkova
- Laboratory of the Mosaic of Autoimmunity
- Department of Pathology
- Saint Petersburg State University
- Saint Petersburg
- Russia
- Department of Hospital Therapy Named after Academician M.V. Chernorutskii
- Research Institute of Rheumatology and Allergology
- Pavlov First Saint Petersburg State Medical University
- Saint Petersburg
- Russia
- Isa Seida
- International School of Medicine
- Istanbul Medipol University
- Istanbul
- Turkey
- Kassem Sharif
- Department of Gastroenterology
- Sheba Medical Centre
- Tel-Hashomer
- Israel
- Sackler Faculty of Medicine
- Tel Aviv...
