Workbook for Organic Synthesis

One approach to organic synthesis is retrosynthetic analysis. Withthis approach chemists start with the structures of their targetmolecules and progressively cut bonds to create simpler molecules.Reversing this process gives a synthetic route to the targetmolecule from simpler starting materials. This"disconnection" approach to synthesis is now afundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach,2nd Edition This workbook provides a comprehensive graded set of problems toillustrate and develop the themes of each of the chapters in thetextbook Organic Synthesis: The Disconnection Approach,2nd Edition. Each problem is followed by a fullyexplained solution and discussion. The examples extend thestudent's experience of the types of molecules beingsynthesised by organic chemists, and the strategies they employ tocontrol their syntheses. By working through these examples studentswill develop their skills in analysing synthetic challenges, andbuild a toolkit of strategies for planning new syntheses. Examplesare drawn from pharmaceuticals, agrochemicals, natural products,pheromones, perfumery and flavouring compounds, dyestuffs,monomers, and intermediates used in more advanced synthetic work.Reasons for wishing to synthesise each compound are given. Togetherthe workbook and textbook provide a complete course inretrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2ndEdition There are forty chapters in Organic Synthesis: TheDisconnection Approach, 2nd Edition: those on thesynthesis of given types of molecules alternate with strategychapters in which the methods just learnt are placed in a widercontext. The synthesis chapters cover many ways of making each typeof molecule starting with simple aromatic and aliphatic compoundswith one functional group and progressing to molecules with manyfunctional groups. The strategy chapters cover questions ofselectivity, protection, stereochemistry, and develop more advancedthinking via reagents specifically designed for difficult problems.In its second edition updated examples and techniques are includedand illustrated additional material has been added to take thestudent to the level required by the sequel, Organic Synthesis:Strategy and Control. Several chapters contain extensive newmaterial based on courses that the authors give to chemists in thepharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach,2nd edition, combined with the main textbook,provides a full course in retrosynthetic analysis for chemistry andbiochemistry students, and a refresher course for organic chemistsworking in industry and academia.