Cell-Based Biosensors

Name: Cell-Based Biosensors | Principles and Applications
Brand: Artech House
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Principles and Applications

Ping Wang(Author)

Artech House (Publisher)

1st Edition

Published on 1. January 2009

286 pages

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978-1-59693-440-5 (ISBN)

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Cell-Based BiosensorsPrinciples and Applications
Contents
Foreword
Preface
Acknowledgments
Chapter 1 Introduction
1.1 Defi nition of Cell-Based Biosensors
1.2 Characteristics of Cell-Based Biosensors
1.3 Types of Cell-Based Biosensors
1.4 Summary
References
Chapter 2 Cell Culture on Chips
2.1 Introduction
2.2 Cell Immobilization Factors
2.2.1 Physical Factors
2.2.2 Chemical Factors
2.2.3 Biological Factors
2.3 Basic Surface Modifi cation Rules
2.3.1 Hydrophilicity Improving
2.3.2 Roughness Changing
2.3.3 Chemical Coating
2.4 Typical Methods
2.4.1 Special Physical Structure
2.4.2 Microcontact Printing
2.4.3 Fast Ink-Jet Printing
2.4.4 Perforated Microelectrode
2.4.5 Self-Assembled Monolayer
2.4.6 Microfl uidic Technology
2.5 Summary
References
Chapter 3 Mechanisms of Cell-Based Biosensors
3.1 Introduction
3.2 Metabolic Measurements
3.2.1 Cell Metabolism
3.2.2 Extracellular pH Monitoring
3.2.3 Other Extracellular Metabolite Sensing
3.2.4 Secondary Transducers
3.3 Action Potential Measurements
3.3.1 Action Potential
3.3.2 The Solid-Electrolyte Interface
3.3.3 Cell-Electrode Interface Model
3.3.4 Cell-Silicon Interface Model
3.3.5 Secondary Transducers
3.4 Impedance Measurements
3.4.1 Membrane Impedance
3.4.2 Impedance Model of Single Cells
3.4.3 Impedance Model of Populations of Cells
3.4.4 Secondary Transducers
3.5 Noise Sources
3.5.1 Electrode Noise
3.5.2 Electromagnetic Interference
3.5.3 Biological Noise
3.6 Summary
References
Chapter 4 Microelectrode Array (MEA) as Cell-Based Biosensors
4.1 Introduction
4.2 Principle
4.3 Fabrication and Design of MEA System
4.3.1 Fabrication
4.3.2 Different MEA Chips
4.3.3 Measurement Setup
4.4 Theoretical Analysis of Signal Process in MEA Systems
4.4.1 Equivalent Circuit Model of Signal Process
4.4.2 Impedance Properties Analysis of MEA
4.4.3 Analysis of Extracellular Signal
4.5 Application of MEA
4.5.1 Dissociated Neural Network on MEA
4.5.2 Slice on MEA
4.5.3 Retina on MEA
4.5.4 Pharmacological Application
4.6 Development Trends
4.6.1 Lab on a Chip
4.6.2 Portable MEA System
4.6.3 Other Developmental Trends
4.7 Summary
References
Chapter 5 Field Effect Transistor (FET) as Cell-BasedBiosensors
5.1 Introduction
5.2 Principle
5.3 Device and System
5.3.1 Fabrication of FET-Based Biosensor
5.3.2 FET Sensor System
5.4 Theoretical Analysis
5.4.1 Area-Contact Model
5.4.2 Point-Contact Model
5.5 Application
5.5.1 Electrophysiological Recording of Neuronal Activity
5.5.2 Two-Way Communication Between Silicon Chip and Neuron
5.5.3 Neuronal Network Study
5.5.4 Cell Microenvironment Monitoring
5.6 Development Trends
5.7 Summary
References
Chapter 6 Light Addressable Potentiometric Sensor (LAPS) as Cell-Based Biosensors
6.1 Introduction
6.2 Principle
6.2.1 Fundamental
6.2.2 Numerical Analysis
6.3 Device and System
6.3.1 Device
6.3.2 Microphysiometer System
6.3.3 Detecting System of Cell-Semiconductor Hybrid LAPS
6.4 Application
6.4.1 Signaling Mechanism Study
6.4.2 Functional Characterization of Ligand/Receptor Binding
6.4.3 Identifi cation of Ligand/Receptor
6.4.4 Drug Analysis
6.5 Developing Trend
6.5.1 LAPS Array System for Parallel Detecting
6.5.2 Multifunctional LAPS System
6.6 Summary
References
Chapter 7 Electric Cell-Substrate Impedance Sensor (ECIS) as Cell-Based Biosensors
7.1 Introduction
7.2 Principle
7.2.1 Electrochemical Impedance
7.2.2 Cell-Substrate Impedance
7.2.3 AC Frequency and Sensitivity Characteristics of Interdigitated Electrodes
7.3 Device and System
7.3.1 Device Fabrication
7.3.2 Bioimpedance Measurement System
7.4 Theoretical Analysis
7.4.1 Lumped Model
7.4.2 Analytical Model
7.4.3 Data Calculation and Presentation
7.5 Applications
7.5.1 Monitoring of Cell Adhesion, Spreading, Morphology, and Proliferation
7.5.2 Monitoring of Cell Migration and Invasion
7.5.3 Monitoring of Cellular Ligand-Receptor Interactions
7.5.4 Cytotoxicity Assays
7.6 Development Trends
7.6.1 High-Throughput Screening
7.6.2 Integrated Chip
7.7 Summary
References
Chapter 8 Patch Clamp Chip as Cell-Based Biosensors
8.1 Introduction
8.2 Theory
8.2.1 Conventional Patch Clamp
8.2.2 Patch Clamp Chip
8.3 Sensor Device and System
8.3.1 Patch Clamp Chip Device
8.3.2 Patch Clamp Chip System
8.3.3 Cells Preparation
8.4 Biomedical Application
8.4.1 Ionic Channels Research
8.4.2 Drug Discovery
8.4.3 Drug Safety
8.5 Development Trends
8.6 Summary
References
Chapter 9 Other Cell-Based Biosensors
9.1 Quartz Crystal Microbalance (QCM) as Cell-Based Biosensors
9.1.1 Introduction
9.1.2 Principle of QCM
9.1.3 QCM Sensors and Measurement System
9.1.4 Biomedical Application
9.2 Surface Plasmon Resonance (SPR) as Cell-Based Biosensors
9.2.1 Introduction
9.2.2 The Principle of SPR
9.2.3 SPR Sensors and Measurement System
9.2.4 Biomedical Application
9.3 Immune Cell-Based Biosensors
9.3.1 Introduction
9.3.2 Mast Cell-Based Biosensors
9.3.3 Dendritic Cell-Based Biosensors
9.3.4 B Cell-Based Biosensors
9.4 Summary
References
Chapter 10 Developments of Cell-Based Biosensors
10.1 Introduction
10.2 Cell-Based Biosensors with Integrated Chips
10.2.1 Integration Chip of the Same or Similar Functional Sensors
10.2.2 Multisensors Involve Sensing Elements with Different Functions
10.2.3 Multifunctional Chip Monitoring Different Parameters
10.3 Cell-Based Biosensors Using Nanotechnology
10.3.1 Nano-Micropatterned Cell Cultures
10.3.2 Nanoporous-Based Biosensor
10.3.3 Nanoprobes to Intracellular Nanosensors
10.4 Cell-Based Biosensors with Microfl uidic Chips
10.4.1 Microfl uidic Flow
10.4.2 Soft Lithography
10.4.3 Dielectrophoresis
10.5 Biomimetic Olfactory and Gustatory Cell-Based Biosensors
10.5.1 Bioelectronic Nose and Bioelectronic Tongue
10.5.2 Olfactory and Gustatory Biosensors with Special Receptors
10.5.3 Olfactory and Gustatory Cell-Based Biosensors
References
Glossary
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