Vitamins and Hormones
Academic Press
Published on 18. May 1976
742 pages
978-0-08-086630-7 (ISBN)
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Vitamins and Hormones
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04/1976
Academic Press
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Content
- Front Cover
- Vitamins and Hormones
- Copyright Page
- Contents
- Contributors to Symposium
- Contributors Regular Articles
- Preface
- Organizing Committee For Symposium
- Part I: Endocrine Control of the Prostate An International Symposium in Honor of Dr. Charles Huggins
- Chapter 1. Morphological and Biochemical Parameters of Androgen Effects on Rat Ventral Prostate in Organ Culture
- I. Introduction
- II. Morphological Studies in Static and Constant-Flow Culture
- III. Biochemical Studies of Protein and RNA Synthesis in Cultured Explants
- IV. The RNA Synthesizing Machinery in Prostatic Epithelial Cells
- V. Discussion and Conclusions
- References
- Discussion
- Chapter 2. Polynucleotide Polymerizations and Prostate Proliferation
- I. DNA Replication and Rat Prostate Growth
- II. Multiplicity of DNA Polymerizing Enzymes
- III. New Explorations of Prostatic Polynucleotide Polymerase Reactions
- IV. Effects of Androgens
- V. Remarks on Polyamines
- VI. Prospectives
- Note Added in Proof
- References
- Discussion
- Chapter 3. Hormonal Effects on Cell Proliferation in Rat Prostate
- I. Introduction
- II. Homeostatic Constraint Mechanisms
- III. Factors Affecting the Function of Homeostatic Constraint Mechanisms
- IV. Hypothesis: Initiator, Xullifier, and Autophage Genes
- V. Summary
- References
- Discussion
- Chapter 4. Animal Models in the Study of Antiprostatic Drugs
- I. Introduction
- II. Morphology and Hormonal Regulation of the Prostate of Various Species
- III. Effect of Exogenously Administered Hormones on the Function of the Normal Prostate
- IV. Spontaneous Tumors of the Prostate in Animals and the Influence of Hormones
- V. Experimental Induction of Prostatic Tumors
- VI. Tissue Culture of Prostatic Tumors
- VII. Heterologous Transplantation of Prostatic Tumors and the Influence of Hormones
- VIII. Summary and Conclusions
- References
- Discussion
- Chapter 5. Effects of Hormone-Cytostatic Complexes on the Rat Ventral Prostate In Vivo and In Vitro
- I. Introduction
- II. Effects of Hormone-Cytostatic Complexes
- III. Conclusions
- References
- Discussion
- Chapter 6. Potential Test Systems for Chemotherapeutic Agents against Prostatic Cancer
- I. Introduction
- II. The 5a-Reductase (5a-RA) Enzyme System
- III. Prostatic Arginase Activity
- IV. Deposition of Labeled Steroids in the Dog Prostate
- V. Comments
- VI. Concluding Remarks
- References
- Discussion
- Part II: Round Table Discussion on the Evaluation of Drugs and Hormones Effective against Prostatic Disease
- Chapter 7. Androgen Metabolism by the Perfused Prostate
- I. Introduction
- II. The Perfused Prostate
- III. Androgen Metabolism in the Perfused Prostate
- References
- Discussion
- Chapter 8. Production of Testosterone by Prostate and Other Peripheral Tissues in Man
- I. Introduction
- II. Methodology
- III. Origin of Androgens
- IV. Androgenicity
- References
- Discussion
- Chapter 9. Steroid Hormone Receptors: A Survey
- I. Introduction
- II. Entry and Release of Steroid Hormones
- III. Steroid Antagonists
- IV. Steroid Metabolism
- V. Purification of Steroid-Receptor Complexes
- VI. Specificity of Hormonal Responses
- VII. Conclusions
- References
- Discussion
- Chapter 10. Androgen Binding and Metabolism in the Human Prostate
- I. Introduction
- II. The Nonneoplastic Prostate
- III. The Scoplastic Prostate
- IV. Androgen Metabolism in Human Prostate
- References
- Discussion
- Chapter 11. Testosterone Receptors in the Prostate and Other Tissues
- I. General Introduction
- II. Testosterone and Its "Active Metabolites"
- III. Evidence for a Biological Role for DHT and Testosterone
- IV. Methodological Problems in the Study of Androgen-Receptor Proteins in Different Target Tissues in Vitro
- V. Factors That Favor the Binding of Testosterone or DHT to Receptor Proteins in Vitro
- VI. The Striking Similarity of Testosterone and DHT Receptor Proteins in Different Tissues
- VII. Cytosol Receptor Proteins and the Activity of Other 5a-Reduced Active Metabolites
- VIII. Are Testosterone-Receptor Complexes Active Mediators of Androgen Action?
- IX. Conclusions
- References
- Discussion
- Chapter 12. Androgen Binding and Transport in Testis and Epididymis
- I. Introduction
- II. The Testis as A Target Organ for Androgens
- III. The Epididymis as a Target Organ for Androgens
- IV. Androgen Rcceptors in Testis and Epididymis
- V. Androgen Transport and Retention within the Testis and the Epididymis
- VI. Androgen-Binding Protein (ABP) in Seminiferous Fluid and Epididymis
- VII. Conclusions
- References
- Discussion
- Chapter 13. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate
- I. Introduction
- II. Multiple Forms of Androgen-Receptor Complexes
- III. Androgen-Receptor Evaluation
- IV. Interaction of Dihydrotestosterone-Receptor Complex with Cellular Components
- V. Receptor Transformation and Nuclear Acceptor Molecules
- VI. Androgen and Gene Expression
- References
- Discussion
- Chapter 14. Androgen Receptors in the Rat Ventral Prostate and Their Hormonal Control
- I. Introduction
- II. Methods for the Quantitation of Androstanolone Binding Constants at Equilibrium in Rat Ventral Prostate Extracts
- III. The Control of Androgen Receptors in the Rat Ventral Prostate
- References
- Discussion
- Part III. Round Table Discussion on Prostatic Receptors
- Chapter 15. Treatment of Prostatic Carcinoma with Various Types of Estrogen Derivatives
- I. Clinical Results
- II. Steroid Levels
- III. Discussion
- IV. Concluding Remarks
- References
- Discussion
- Chapter 16. The Nonsurgical Treatment of Prostatic Carcinoma
- I. Introduction
- II. Presentation of Prostatic Carcinoma
- III. Natural History
- IV. Investigation in Relation to Staging
- V. Endocrine Therapy
- VI. Radiotherapy
- VII. Summary and Treatment Protocol
- References
- Discussion
- Chapter 17. Management of Reactivated Prostatic Cancer
- I. Scope of the Problem
- II. The Basis for Hormonal Therapy
- III. Further Hormonal Manipulation in Relapsing Metastatic Prostatic Cancer
- IV. Newer Agents
- V. Summary and Conclusions
- References
- Discussion
- Chapter 18. Androgen Metabolism in Patients with Benign Prostatic Hypertrophy
- I. Introduction
- II. Androgens in Biological Fluids: Influence of Aging and Benign Prostatic Hypertrophy (BPH)
- III. Androgens in Prostate Tissue and Skeletal Muscle
- IV. Conclusions
- References
- Discussion
- Chapter 19. Nonsurgical Treatment of Human Benign Prostatic Hyperplasia
- I. Human Benign Prostatic Hyperplasia
- II. Canine Benign Prostatic Hyperplasia
- III. Conclusions
- References
- Discussion
- Chapter 20. Thiaminases and Their Effects on Animals
- I. Introduction
- II. Thermolabile Thiamine-Inactivating Systems
- III . Thermostable Factors That React with Thiamine
- IV. The "Antithiamine" Factors in Bracken Fern
- V. Effects of Thiaminases on Animals
- VI. Physiological Significance of the Thiaminases
- References
- Chapter 21. Pellagra and Amino Acid Imbalance
- I. Introduction
- II. Etiology
- III. Biochemical Changes
- IV. Effects of Excess Leucine
- V. Mental Changes in Pellagra
- VI. The Skin in Pellagra
- VII. Leucine-Isoleucine Imbalance
- VIII. Summary and Concluding Remarks
- References
- Chapter 22. Myo-inositol Lipids
- I. Introduction
- II. Metabolism in Outline
- III. Chemical Synthesis of Phosphatidylinositol
- IV. Extraction and Separation Methods
- V. Analysis and Distribution
- VI. Physical Properties of Phosphoinositides
- VII. Metabolism in Various Tissues and Organisms
- VIII. Phosphatidylinositol Turnover and Plasma Membrane Activation
- References
- Chapter 23. Hormonal Regulation of Cartilage Growth and Metabolism
- I. Introduction
- II. Chemistry and Physiology of Hyaline Cartilage
- III. Effects of Hormones on Cartilage Growth and Metabolism
- IV. Metabolic Regulation
- V. Summary and Conclusions
- References
- Chapter 24. Steroid Hormone Receptors
- I . Introduction
- II. Historical Background
- III . Estrogen Receptors
- IV. Progesterone Receptors
- V. Androgen Receptors
- VI . Glucocorticosteroid Receptors
- VII . Mineralocorticosteroid Receptors
- VIII. Ecdysone, Vitamin D, and Thyroid Hormones
- IX. Receptors and Hormone Action: Steroid Receptors in Target Cell Nuclei
- X. Steroid Hormones and Prevision of Hormone Dependence of Human Cancer
- XI. Detection and Characterization of Steroid Receptor Interactions
- XII. Conrlusions: Are Receptors the "Real" Receptors? Complexity and Physiopharmacological Interest
- References
- Addendum
- Subject Index
