
Vitamins and Hormones
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Content
- Front Cover
- Vitamins and Hormones: Advances in Research and Applications
- Copyright Page
- Contents
- Contributors to Volume 22
- Preface
- Chapter 1. Biochemistry of Biotin
- I. Introduction
- II. Biogenesis of Biotin and Biotin Holoenzymes
- III. Tissue Distribution and Metabolism of Biotin
- IV. Structure and Specificity of Biotin
- V. Biotin Enzymes
- VI. Mechanism of Action of Enzyme-Bound Biotin
- VII. Indirect Effects of Biotin Deficiency
- References
- Chapter 2. The Biochemistry of the Inositol Lipids
- I . Introduction
- II. Chemical Structure
- III. Distribution of Inositol Lipids
- IV. Biosynthesis
- V. Enzymatic Hydrolysis of Phosphoinositides
- VI. Possible Physiological Roles of Phosphoinositides
- References
- Chapter 3. The Role of Organ Cultures in the Study of Vitamins and Hormones
- I. Introduction
- II. Vitamins
- III. Hormones
- IV. Conclusion
- References
- Chapter 4. Therapy of Gynecological Disorders with Human Gonadotropin
- I. Introduction
- II. Human Chorionic Gonadotropin (HCG)
- III. Human Pituitary Gonadotropin (HPFSH)
- IV. Human Menopausal Gonadotropin (HMG)
- V. Concluding Remarks
- References
- Chapter 5. The Biochemistry of Progesterone
- I. Introduction
- II. Production and Metabolism of Progesterone
- III. Progesterone-Gonadotropin Interrelationships
- IV. Metabolic Effects of Progesterone
- V. Biochemical Effects of Progesterone on the Uterus
- VI. Effect of Progesterone on Enzyme Systems in Vitro
- VII . Concluding Remarks
- References
- Chapter 6. The Role of the Brain in the Regulation of Pituitary
- I. Introduction
- II. Dependence of GTH Secretion on Hypothalamic Neurohurnors
- III. Direct Evidence about Neurohumors Which Influence GTH Secretion
- IV. Gonadal Steroid Feedback
- V. The Role of the Brain in the Control of Ovulation
- VI. Summary
- References
- Chapter 7. Cellular and Molecular Aspects of the Antidiuretic Action of Vasopressins and Related Peptides
- I. Introduction
- II. Nomenclature
- III. Assay and Standardization
- IV. Structure-Activity ReIationships of the Neurophypophyseal Hormones
- V. Mechanism of Antidiuresis: Facts and Theories
- References
- Chapter 8. International Symposium on Vitamin B6 in Honor of Professor Paul György
- The History of Vitamin B6. Introductory Remarks
- Text
- References
- Chapter 9. Synthesis and Labeling of the Vitamin B6 Group
- I. Introduction
- II. Syntheses of Pyridoxine
- III. C14-Labeled Pyridoxine
- IV. Pyridoxine 5-Phosphate
- V. Pyridoxal
- VI. Pyridoxal 5-Phosphate (Codecarboxylase)
- VII. Pyridoxamine
- VIII. N15-Labeled Pyridoxamine
- IX. Pyridoxanmine 5-Phosphate
- X. Summary
- Referencres
- Chapter 10. Phosphorylase and Related Enzymes of Glycogen Metabolism
- I. Introduction
- II. Pathways of Glycogenesis and Glycogenolysis
- III. Interconversion of the Two Forms of Glycogen Phosphorylase
- IV. The Structure and Properties of Glycogen Phosphorylase
- V. Vitamin B6 Deficiency and Carbohydrate Metabolism
- VI. Muscle Phosphorylase as a Repository for Vitamin B6 in the Animal
- References
- Chapter 11. Comparative Studies on Glutamic-Oxalacetic Transaminases from the Mitochondrial and Soluble Fractions of Mammalian Tissues
- I. Introduction
- II. Pyridoxamine Transaminase
- III. Identity of Pyridoxamine-Oxalacetic Transaminase with the Apoprotein of Glutamic-Oxalacetic Transaminase
- IV. Glutamic-Oxalacetic Transaminases from Mitochondrial and Soluble Fractions of Mammalian Tissues
- V. Concluding Remarks
- References
- Chapter 12. Amino Acid Decarboxylation Steps in the Biosynthesis of Norepinephrine, Serotonin, and Histamine
- I. Introduction
- II. Norepinephrine
- III. Serotonin
- IV. Histamine
- V. Summary
- References
- Chapter 13. Binding and Reactions of the Vitamin B6 Coenzyme in the Catalytic Center of Aspartate Transaminase
- I. Introduction
- II. The Linkage of Coenzyme and Apoenzyme in the Catalytic Center of Aspartate Transaminase
- III. Reactions of Substrates and Inhibitors with the Coenzyme in the Catalytic Center
- IV. Spectropolarimetric Investigation of Aspartate Transaminase
- V. Concluding Remarks
- References
- Addenda
- Chapter 14. Summary of Session I and Some Notes on the Metabolism of Vitamin B6
- I. Observations Relevant to the Preceding Papers
- II. Pyridoxal Kinase in Vitamin B6 Metabolism
- III. Concluding Remarks
- References
- Chapter 15. Biochemical Pathology of Vitamin B6 Deficiency
- I. Introduction
- II. Activities of Pyridoxal Phosphate Enzymes in Progressive Vitamin B6 Deficiency
- III. Metabolic Alterations in the Vitamin B6 Deficiency State
- IV. Summary
- References
- Chapter 16. ?-Aminobutyric Acid (?ABA), Vitamin B6, and Neuronal Function-A Speculative Synthesis
- I. Introduction
- II. The Synapse as a Common Ground for Chemist and Biologist
- III. ?ABA Shows Some of the Properties Expected of the Hypothetical Synaptic Negative Feedback Transmitter
- IV. Relations between Apoenzymes (or Nonenzymatic Proteins) and Vitamin B6
- V. Some Carbonyl Reagents Can Produce Conclusive Seizures and Defects in Collagen Structure
- VI. Correlations with the Proposed Synaptic Model
- VII. Comment
- References
- Chapter 17. Vitamin B6 and Amino Acids-Recent Research in Animals
- I. Introduction
- II. Vitamin B6 Intake and Amino Acid Metabolism
- III. Vitamin B6 and Amino Acid Transport
- IV. Adaptive Changes in Levels of Activity of Vitamin B6 Enzymes
- V. Summary
- References
- Chapter 18. Vitamin B6 and Oxalate Metabolism
- I. Introduction
- II. Aminal Studies
- III. Metabolic Studies
- IV. Human Studies
- V. Summary
- References
- Chapter 19. Relationship of Pyridoxine to Immunological Phenomena
- I. Introduction
- II. Relationship of Pyridoxine to Immune Processes
- III. Mechanism of Action of Pyridoxine
- IV. Summary
- References
- Chapter 20. Selective Metabolic and Chemotherapeutic Effects of Vitamin B6 Antimetabolites
- I. Introduction
- II. Inhibition of Growth of Experimental Tumors
- III. Vitamin B6 Deficiency and Cancer in Man
- IV. Selective Effects of Pyridoxine Deficiency
- V. Means of Interfering with Pyridoxine Metabolism
- VI. Concluding Remarks
- References
- Chapter 21. Effects of Low Intakes of Vitamin B6 upon Diabetic and Control Rats
- I. Introduction
- II. Experimental
- III. Results
- IV. Summary
- References
- Chapter 22. Summary and Comment on Tissue Changes in Vitamin B6 Deficiency
- Text
- Chapter 23. Vitamin B6 in Farm Animal Nutrition and Pets
- I. Introduction
- II. Poultry
- III. Swine
- IV. Dogs
- V. Other Animals
- VI. Practical Considerations
- References
- Chapter 24. Arteriosclerotic, Dental, and Hepatic Lesions in Pyridoxine-Deficient Monkeys
- I. Introduction
- II. Arteriosclerotic Lesions
- III. Dental Lesions
- IV. Hepatic Lesions
- V. Summary
- References
- Chapter 25. Effect of Vitamin B6 on Dental Caries in Man
- I. Introduction
- II. The Oral Environment
- III. Epidemiological Observations
- IV. Clinical Studies
- V. Summary and Conclusions
- References
- Chapter 26. Evidence for a Relative Vitamin B6 Deficiency in Pregnancy and Some Disease States
- I. Introduction
- II. Abnormal Tryptophan Metabolism
- III. Determination of Transaminases in Circulating Blood
- IV. Urinary Estimation of 4-Pyridoxine Acid
- V. Vitamin B6 Content of the Circulating Blood
- VI. B6 Content of Timues during Pregnancy
- VII. Concluding Remarks
- References
- Chapter 27. Pyridoxine-Responsive Anemia-Prototype and Variations on the Theme
- I. Introduction
- II. The Prototype
- III. Signs, Symptoms, and Laboratory Findings in Pyridoxine-Responsive Anemia: Variations Documented among 72 Acceptable Cases
- IV. Etiology and Pathogenesis
- V. Summary
- References
- Chapter 28. Vitamin B6 Metabolism in Infants and Children
- I. Introduction
- II. Vitamin B6 Deficiency
- III. Vitamin B6 Dependency
- IV. Other Central Nervous System Disorders in Which B6 May Have a Role
- V. Anemia as a Symptom of Abnormal Vitamin B6 Metabolism
- VI. Inhibitors of Vitamin B6 Activity
- VII. Diagnostic Tests for Derangements of Vitamin B6 Function
- VIII. Nutritional Requirements
- IX. Possible Mechanisms Affecting the Function of Vitamin B6 at the Subcellular Level
- X. Selected Critical Biochemical Roles of Vitamin B6 Affecting Physiologic Function
- XI. Summary
- References
- Chapter 29. Vitamin B6 in Fat Metabolism
- I. Introduction
- II. Animal Studies
- III. Human Studies
- IV. Summation
- References
- Chapter 30. The Vitamin B6 Hydrazide Relationship
- I. Introduction
- II. INH Neuritis-Relationship to Vitamin B6 Metabolism
- III. INH Relationship to Vitamin B6-Responsive Anemia
- IV. Effect of Vitamin B6 on the Antimetabolic Activity of INH
- V. Effect of Other Hydrazides and Chelating Agents on Vitamin B6 Metabolism
- VI. Effect of INH on Tryptophan Metabolism
- VII. Chemical Mechanism of the Hydrazide Effect
- VIII. Summary
- IX. Discussion and Summary of Session on Nutritional Role of Vitamin B6
- References
- Chapter 31. Human Requirements for Vitamin B6
- I. Introduction: Occurrence of Vitamin B6 Deficiency in the Human Being
- II. Estimation of the Vitamin B6 Requirement of the Human
- III. Summary
- References
- Chapter 32. Recent Developments in the Analysis for Vitamin B6 in Foods
- I. Introduction
- II. Chromatographic Sepctration
- III. Microbiological Procedures
- IV. Comparative Data
- V. Fluorometric Procedures
- References
- Chapter 33. Methods for the Determination of Vitamin B6 in Biological Materials
- I. Introduction
- II. Extraction of Vitamin B6
- III. Determination of Vitamin B6
- IV. Determination of 4-Pyridoxic Acid
- V. Concluding Remarks
- References
- Chapter 34. The Relation of the Vitamin B6 Human Requirement to the Amount in the Diet
- I. Introduction
- II. Experimental Determinations
- III. Discussion
- References
- Chapter 35. The Importance of Vitamin B6 in Human Nutrition
- Text
- References
- Concluding Remarks
- Text
- Author Index
- Topical Index
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