Advances in Cancer Research
Published on 28. June 2011
200 pages
978-0-12-385525-1 (ISBN)
Description
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
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George F. Vande Woude | George Klein
Advances in Cancer Research: Volume 111
Book
08/2011
Academic Press
€154.75
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Content
- Cover
- Advanced in Cancer Research
- Copyright
- Contents
- Contributors
- Is Survivin the Potential Achilles' Heel of Cancer?
- Introduction
- Survivin, A Member of the Inhibitors of Apoptosis Protein Family
- Cell Biology Of Survivin
- Regulation of Survivin Expression
- The Multiple Functions of Survivin
- Molecular Targeting of Survivin in Cancer Therapy
- Survivin As A Generic Tumor-Associated Antigen
- Immune Recognition of Survivin
- Experimental Vaccines Targeting Survivin
- Dendritic Cell-Based Vaccines
- Naked Dna Vaccines
- Survivin-Based Vaccines in the Clinic
- Potential Pitfalls Associated With Survivin-Based Th erapies
- Survivin Expression in Nontransformed Adult Tissues
- Oncogenic Potential Associated with Survivin Gene Transfer
- Risks of Autoimmunity
- Concluding Remarks
- Acknowledgments
- References
- The Essential Role of Evasion from Cell Death in Cancer
- Introduction To Apoptosis Signaling
- The Bcl-2 family regulated apoptotic pathway
- Interactions between the different subgroups of the Bcl-2 family regulate apoptosis
- Functions and regulation of the prosurvival Bcl-2 proteins
- The control of prosurvival Bcl-2 family member expression and function
- Functions and regulation of the multi-BH domain proapoptotic Bax/Bak proteins
- Functions and regulation of the BH3-only proteins
- Chromosomal Translocations that Cause Abnormal Overexpression of the Bcl-2 Prosurvival Proteins in Cancer
- Copy-Number Variations In Bcl-2 Family Prosurvival Genes In Cancer
- Expression Of Bcl-2 Prosurvival Proteins In Cancer
- Role Of Bcl-2 Prosurvival Proteins For The Development And Sustained Growth Of Cancers
- Expression Of Viral Bcl-2 Prosurvival Proteins In Cancer
- Potential Therapies Based On Neutralizing Prosurvival Bcl-2 Proteins
- Acknowledgments
- References
- Faulty Epithelial Polarity Genesand Cancer
- Introduction
- Building Blocks of Epithelial Polarity
- Cell Polarity in Normal Epithelial Function
- Epithelial Cell Junctions
- Tight Junctions
- Adhesion and Desmosomal Junctions
- Hemidesmosomes and Basement Membrane
- Molecular Machinery for Maintenance of Polarity
- Segregation and Reciprocal Inhibition of Polarity Complexes
- Lipid Signaling
- Protein Sorting and Trafficking
- Core Polarity Complexes
- Par
- Par Genes in Polarity Regulation
- Apical Players: Par3, Par6, aPKC
- Lateral and Center Players: Par1, Par5
- Tumor Suppressor Gene LKB1/Par4
- Crumbs
- Scrib
- Enzymatic Polarity Control
- Rho GTPases CDC42, RAC1, and RHOA
- RHO GTPases in Control of Adhesion Junctions
- Crosstalk between RHO GTPases, and PAR and CRB Complexes in Control of Apical Domain
- RHO GTPases, Polarity, and Microenvironment
- Serine/Threonine Protein Kinase apkc and Lipid Kinase pi3k
- aPKC
- PI3K
- Type II Transmembrane Serine Proteases
- Matriptase
- Glycosylphosphatidylinositol (GPI)-Anchored Prostasin
- Hepsin
- Epithelial Polarity Genes and Cancer
- Neoplastic and Hyperplastic Tumor Suppressor Genes
- Polarity Genes in Human Cancer
- PAR6 and par3 in Cancer
- aPKC in Cancer
- LKB1 in Cancer
- Crumbs in Cancer
- Scribble in Cancer
- Rho GTPase Dysregulation in Cancer
- Pi3k and Pten in Cancer
- Matriptase, Prostasin, and Hepsin in Cancer
- Epithelial Polarity Mechanisms as Therapeutic Target
- Reversion of Malignant Epithelium
- RHO GTPases, Reversion of Ras Transformation and Inhibitors
- Integrins, Reversion of Transformation and Inhibitors
- Pi3k, Reversion of Transformation and Inhibitors
- Targeting Pathways Coupling Polarity with Proliferation and Apoptosis
- Polarity Proteins and Cell Proliferation
- apkc Inhibitors
- Ttsp Inhibitors
- Matriptase Inhibitors
- Hepsin Inhibitors
- Polarity Proteins and Apoptosis
- Acknowledgments
- References
- Adult T Cell Leukemia/Lymphoma: FoxP3+ Cells and the Cell-Mediated Immune Response to HTLV-1
- IntroductionPlease check the order of section headings for correctness.
- Adult T Cell Leukemia/Lymphoma
- Cellular Immune Response To Htlv-1
- foxp3 and regulatory t cells
- What is the Frequency of FoxP3 Expression in Nonmalignant HTLV-1 Infection (Toulza et al., 2008)?
- Do CD4+ FoxP3+ T Cells Act as Tregs in HTLV-1 Infection (Toulza et al., 2008)?
- What is the Frequency of FoxP3+ Cells in ATLL (Toulza et al., 2009)?
- Do FoxP3+ Cells in Cases of ATLL Act as Tregs (Toulza et al., 2009)?
- What Causes the High Frequency of FoxP3+ Cells in HTLV-1 Infection (Toulza et al., 2010)?
- Conclusions
- Acknowledgments
- References
- Index
