Catecholamines: Basic and Clinical Frontiers
Proceedings of the Fourth International Catecholamine Symposium, Pacific Grove, California, September 17-22, 1978
Published on 12. September 2013
1060 pages
978-1-4832-8363-0 (ISBN)
Description
Catecholamines: Basic and Clinical Frontiers is a collection of papers that discusses clinical problems related to this series of compounds which includes dopamine, epinephrine, and norepinephrine. One paper discusses the role of biogenic amines in several mental disorders, such as senile dementia, schizophrenia, chronic alcoholism, and affective disorders. Another paper describes that in studies of mice, the number of neurotransmitter-specific neurons is under a genetic control and can be a significant determinant of species-dependent variation in brain chemistry, nuclear organization, drug responses, and spontaneous behavior. One paper investigates if prostaglandins can directly alter the release or reuptake of catecholamines in the central nervous system, as well as their action upon the disposition of different metabolites of dopamine and norepinephrine in brain perfusate. The effects of several drugs on shock elicited fighting in rats show no significant aspects with amphetamine, apomorphine, phenoxybenzamine or phentolamine. The use of clonidine and propranolol shows a significant inhibition of fighting, while low doses of piperoxane exhibits a marked increase in fighting behavior. The collection can prove beneficial for pharmacologists, biochemists, micro-biologists, cellular researchers, and academicians involved in the study of physiology or neuroendocrinology.
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Content
IntroductionParticipantsAbbreviations Catecholamine Research: A Paradigm for the Relationship Between Basic Investigations and Clinical Applications in Psychiatry The Impact of Catecholamine Research on Medical Science and PracticeSection A: Catecholamine Synthesis and Catabolism A Genetic Control of the Number of Central Dopamine Neurons in Relationship to Brain Organization, Drug Responses, and Behavior Regulation of Tyrosine Hydroxylase Activation and Phosphorylation of Tyrosine Hydroxylase by cAMP Direct Phosphorylation of Tyrosine Hydroxylase by Cyclic AMP-Dependent Protein Kinase: Mechanism of Enzyme Activation Tyrosine Hydroxylase from Brain: Phosphorylation of the Enzyme by Cyclic AMP-Dependent Protein Kinase The Activation of Tyrosine Hydroxylase in Noradrenergic Neurons During Acute Nerve Stimulation Serotoninergic Control of Tyrosine Hydroxylase (TH) and Dopamine-ß-Hydroxylase (DBH) in the Rat Locus Coeruleus (LC) The Pharmacology of Striatal Pterins and the Regulation of Dopaminergic Function The Role of Neural Activity in the Regulation of the Biochemistry of Neurons and Their Target Cells Role of Protein Kinase Translocation in the Induction of Tyrosine-3-Monooxygenase (TH) in Adrenal Chromaffin Cell Cultures Relation Between Brain Tyrosine and Catecholamine Synthesis Effect of Bivalent Cations on the Uptake of L-Tyrosine by Synaptosomes Isolated Bovine Adrenal Medullary Cells: Studies on Regulation of Catecholamine Synthesis and Release Central Neurogenic Regulation of Adrenal Tyrosine Hydroxylase Rat Pheochromocytoma Tyrosine Hydroxylase and Dopamine ß Hydroxylase: Purification and Characterization Amphetamine-Induced Inhibition of Synaptosomal Dopamine Synthesis Activation The Involvement of Calcium in the Amphetamine-Induced Stimulation of Dopamine Synthesis in Striatal Slices Regulation of Dopamine Synthesis within Striatal Synaptosomes The Regulation of Tyrosine 3-Monooxygenase Activity in Pheochromocytoma Cells Short- and Long-Term Control of Tyrosine Hydroxylase Activity in Nigrostriatal Dopamine Neurons: Multiple Neural Mechanisms Tyrosine Hydroxylase: A Substrate for Cyclic AMP-Dependent Protein Kinase In Vitro The Effect of Carbachol on the Induction of Tyrosine Hydroxylase Elicited by Compounds which Raise Cyclic AMP Levels in Neuroblastoma Cells Similarities Between the In Vivo Activation of Adrenal Tyrosine Hydroxylase and the In Vitro Activation of the Enzyme by an Adenosine 3',5'-Monophosphate Dependent Protein Phosphorylating System Modulation of Tyrosine Hydroxylase Activity by Phospholipids: The Effects of Phosphatidylinositol The Role of Cyclic Nucleotides in the In Vivo Synthesis of Catecholamines in Rat Brain Significance of Tyrosine Hydroxylase Activation in the Regulation of Dopamine Synthesis Regulation of Hypothalamic Beta-Adrenergic Function by Phosphatidylserine Effect of Nerve Growth Factor on General Grov7th and Differentiation of Sympathetic Neurons: Induction of Ornithine Decarboxylase and Tyrosine Hydroxylase as Respective Examples Tyrosine Hydroxylase Activity in the Mouse Superior Cervical Ganglion Infected with Herpes Simplex Virus Retinal Tyrosine Hydroxylase: Stimulation In Vivo by Light and In Vitro by cAMP-Dependent Protein Phosphorylation Conditions The Metabolism and Function of Monoamines in Iron-Deficient Rats Round Table on: Is There DOPA Decarboxylase in Human Brain? Enzyme-Activated Irreversible Inhibition of Aromatic L-Amino Acid Decarboxylase (AADC) by a-Difluoromethyl DOPA (DFMD, RMI 78.801) and a-Monofluoromethyl DOPA (MFMD, RMI 71.
