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Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field.
The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures.
- Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine
- Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors
- Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems
- Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-0-12-804380-6 (9780128043806)
Schweitzer Classification
1. The Evolutionary Origins of Cancer and of Its Control by Immune Policing and Genetic Suppression2. Cancer Prevalence and Etiology in Wild and Captive Animals3. Infection and Cancer in Nature4. Pseudohypoxia: Life at the Edge5. The Genomic Landscape of Cancers6. The Epigenetic Component in Cancer Evolution7. Evolution of Cancer Defense Mechanisms Across Species8. Coevolution of Tumor Cells and Their Microenvironment: "Niche Construction in Cancer9. Evolutionary Perspective of Tumorigenesis and Antitumor Immunity: A Comparative Approach10. The Response of Cancer Cell Populations to Therapies11. Ecology of the Metastatic Process12. Transmissible Cancer: The Evolution of Interindividual Metastasis13. Cancer in Animals: Reciprocal Feedbacks Between Evolution of Cancer Resistance and Ecosystem Functioning14. Applying Tools From Evolutionary Biology to Cancer Research15. Understanding Ancient Legacies to Expose and Exploit Cancer's Evolutionary Vulnerabilities16. Atavism Theory-An Introductory Discourse17. Toward an Ultimate Explanation of Intratumor Heterogeneity18. Obstacles to the Darwinian Framework of Somatic Cancer Evolution19. Cancer as a Disease of Homeostasis: An Angiogenesis Perspective20. Dormancy: An Evolutionary Key Phenomenon in Cancer Development21. Controlling Rogue Cells in Cancer and Bacterial Infections22. Searching for a Cancer-Proof Organism: It's the Journey That Teaches You About the Destination23. Ecology, Evolution, and the Cancer Patient