Vascular Innervation and Receptor Mechanisms

ContributorsPreface Chapter 1 Introduction: Changing Face of Autonomic and Sensory Nerves in the Circulation I. Introduction II. The Vascular Neuromuscular Junction III. Multiplicity of Transmitters; Cotransmission IV. Sympathetic Perivascular Nerves V. Parasympathetic Perivascular Nerves VI. Sensory-Motor Perivascular Nerves VII. Perivascular Nerves Arising from Intramural Neurons VIII. Neural-Endothelial Interactions in Local Control of Vascular Tone IX. Plasticity of Perivascular Nerves and Endothelial Cells ReferencesPart I Basic Studies Chapter 2 Regulation of the Autonomic Innervation of Blood Vessels during Development and Aging I. Introduction II. The Establishment of Locally Specific Patterns of Innervation during Early Development III. Regulation of Autonomic Neuronal Phenotype during Early Development IV Changes in the Nerve Supply to Blood Vessels during Maturity V. Changes during Aging in Perivascular Nerves VI. Regulatory Factors in Aging of Perivascular Nerves VII. Conclusions References Chapter 3 Endothelial-Derived Relaxing Factors: Focus on Nitric Oxide I. Introduction II. General Considerations III. Biosynthesis of Nitric Oxide IV. Whole Animal Studies with L-Arginine Analogs V. Influence of Nitric Oxide in Different Regions of the Cardiovascular System VI. Conclusions References Chapter 4 The Effect of Endothelin on Circulation System I. Introduction II. Cellular Mechanism of Endothelin-Induced Vasoconstriction III. Hemodynamic Effect of Endothelin IV. Regional System of Regulation of Vasoconstriction by Endothelin V. Conversion from Big Endothelin to Endothelin VI. Interaction of Endothelin to Other Factors VII. Effect of Endothelin on Cardiac Muscle VIII. Physiological and Pathophysiological Significance of Endothelin References Chapter 5 Interaction between Endothelium-Derived Vasoactive Factors and Neurohumoral Substances in the Regulation of Vascular Tone I. Introduction II. Endothelium-Derived Vasoactive Factors III. Neurohumoral Substances and the Endothelium IV. Physiological Significance V. Pathological Consequences of Endothelial Dysfunction VI. Summary and Conclusions References Chapter 6 Modulation of Endothelial-Inflammatory Cell Interactions by Primary Afferent Nerves I. Introduction II. Neural Receptor Mechanisms III. Interaction between Endothelial Cells and Leukocytes in Disease States IV. Summary ReferencesPart II The Sympathetic System Chapter 7 Noradrenaline and Neuropeptide Y in the Sympathetic System: Prejunctional Interactions and Regulation of Release I. Introduction II. Modulatory Mechanisms of Noradrenaline Release III. Modulatory Mechanisms of NPY Release IV. Conclusions References Chapter 8 Neuropeptide Y Receptor Subtypes and Putative Receptor Ligands I. Introduction II. NPY Localization, Release, and Mechanisms in the Cardiovascular System III. Structures of NPY, Peptide YY, and Pancreatic Polypeptide IV. NPY Receptor Subtypes V. NPY Signal Transduction VI. NPY Receptor Ligands References Chapter 9 ATP as a Cotransmitter with Noradrenaline in Sympathetic Perivascular Nerves I. Introduction II. Vascular Actions of Purines III. ATP as an Excitatory Cotransmitter in Sympathetic Nerves IV. Role of ATP in Hypertension V. Functional Significance of Cotransmission VI.