Screening Methods in Pharmacology

ContentsList of Contributors Preface Contents of Volume I Introduction Chapter 1. a-Adrenergic Blocking Agents I. General Considerations II. Methods References Chapter 2. ß-Adrenergic Blocking Agents I. Introduction II. Methods of Screening for ß-Adrenergic Blocking Agents III. Classification of New ß-Adrenergic Blocking Agents IV. Metabolic Effects of ß-Adrenergic Blocking Agents V. Comparison of Methods VI. Use of ß-Adrenergic Blocking Agents in Therapy References Chapter 3. Agents Acting on Coronary Blood Vessels I. Introduction II. Isolated Organs III. Measurement of Coronary Blood Flow of the Heart in Situ IV. Experimental Coronary Insufficiency V. Concluding Remarks References Chapter 4. Agents with Kinin-like Activity I. Introduction II. Methods for Assaying Components of the Plasma Kinin System References Chapter 5. Androgenic and Anabolic Agents I. Introduction II. Methods References Chapter 6. Estrogenic and Antiestrogenic Agents I. Introduction II. Screening Methods for Estrogens III. Screening Methods for Antiestrogens References Chapter 7. Anovulatory Agents I. Introduction II. Screening Assays ReferencesChapter 8. Progestational Agents I. Introduction IL Screening Methods for Progestational Agents III. General Comments References Chapter 9. Antihyperlipidemic Agents I. Introduction II. Historical Review III. Etiology IV. Therapy in Atherosclerosis V. Screening Methods References Chapter 10. Immunosuppressive Agents I. Introduction II. Screening Procedures References Chapter 11. Agents Affecting Mucociliary Activity I. Introduction II. In Vitro Methods III. In Vivo Methods References Chapter 12. Antiperspirant Agents I. Introduction II. Methods References Chapter 13. Antidepressant Agents I. Introduction II. Antagonism of the Effects of Reserpine-like Drugs III. Potentiation of Phenethylamines IV. Muricide Antagonism in Rats V. Effects of Antidepressants on the Autonomic Nervous System VI. Inhibition of Norepinephrine Uptake and Release VII. Monoamine Oxidase Inhibition ReferencesChapter 14. Agents with Analgesic Activity and Dependence Liability I. Introduction II. Analgesic Evaluation III. Characterization for Abuse Potential References Chapter 15. Natriuretic and Antihypertensive Agents Screened by Sequential Methods I. Introduction II. The Design of a Sequential Procedure III. Use of Controls IV. Examples of Design and Use of Sequential Procedures References Author Index Subject Index