Targeted Therapy in Translational Cancer Research
Description
More details
Other editions
Additional editions
Persons
Content
List of Contributors, vii
Series Foreword, xiii
Foreword, xv
Preface, xvii
Part I Principles of Targeted Therapies
1 Toward Personalized Therapy for Cancer, 3
Ashley M. Holder and FundaMeric-Bernstam
2 Combining Targeted Therapies, 14
Jordi Rodon, Analia Azaro, Davis Torrejon, and Razelle Kurzrock
3 Principles of Targeted Immunotherapy, 27
Susanne H. C. Baumeister and Glenn Dranoff
4 Cancer Stem Cell Principles, 39
Allison C. Sharrow, Gabriel Ghiaur, and Richard J. Jones
5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47
Hua Fang and Yves A. DeClerck
6 The Role of Angiogenesis in Cancer, 64
Morgan Taylor, Robert L. Coleman, and Anil K. Sood
7 Epigenetics and Epigenetic Therapy of Cancer, 72
Omotayo Fasan, Patrick Boland, PatriciaKropf, and Jean-Pierre J. Issa
8 The Role of microRNAs in Cancer, 80
Gianpiero Di Leva and Carlo M. Croce
9 AcuteMyeloidLeukemia, 89
Ofir Wolach and Richard M. Stone
10 Targeted and Functional Imaging, 101
Jian Q. (Michael) Yu, Drew A. Torigian, and Abass Alavi
Part II Targeted Therapy in Hematological Malignancies
11 Targeted Therapies in Chronic Myeloid Leukemia, 113
Elias Jabbour and Jorge Cortes
12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121
Nitin Jain, Susan O'Brien, and Farhad Ravandi-Kashani
13 Chronic Lymphocytic Leukemia, 130
Preetesh Jain and Susan O'Brien
14 Multiple Myeloma, 145
Giada Bianchi and Kenneth C. Anderson
15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157
Jens G. Lohr and Birgit Knoechel
16 Targeted Therapy in Myelodysplastic Syndromes, 162
Guillermo Montalb¿an-Bravo and Guillermo Garc¿ya-Manero
17 Lymphoma and Targeted Therapies, 169
Sonali M. Smith and Julie M. Vose
Part III Targeted Therapy in Solid Tumors
18 Targeted Therapy in Solid Tumors: Brain, 179
Shiao-PeiWeathers, Barbara J. O'Brien, John F. de Groot, andW. K. Alfred Yung
19 Targeted Therapy for Breast Cancer, 190
Harold J. Burstein
20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193
Maen Abdelrahim, Scott Kopetz, and David Menter
21 Endometrial Cancer, 205
Jessica L. Bowser, Russell R. Broaddus, Robert L. Coleman, and Shannon N. Westin
22 Targeted Therapy in Solid Tumors: Head and Neck, 216
Marcus M. Monroe and Jeffrey N. Myers
23 Targeted Therapy in Solid Tumors: Lung Cancer, 224
Saiama N.Waqar, Daniel Morgensztern, and Roy S. Herbst
24 Targeted Therapy in Melanoma, 231
Keith T. Flaherty
25 Ovarian Cancer, 240
Shannon N.Westin, Larissa A. Meyer, and Robert L. Coleman
26 Molecular Therapeutics: Pancreatic Cancer, 255
David Fogelman, Milind Javle, and James Abbruzzese
27 Targeted Therapies for Pediatric Solid Tumors, 263
Jasmine Quynh Dao and Patrick A. Zweidler-McKay
28 Prostate Cancer, 273
William G. Nelson, Michael C. Haffner, and Srinivasan Yegnasubramanian
29 Renal Cell Carcinoma and Targeted Therapy, 287
Benjamin A. Gartrell, Alexander C. Small, William K. Oh, and Matthew D. Galsky
30 Targeted Therapy in Solid Tumors: Sarcomas, 296
Anthony P. Conley, Vinod Ravi, and Shreyaskumar Patel
Part IV Targeted Therapy for Specific Molecular Aberrations
31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305
Javier Munoz and Filip Janku
32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315
Samuel J. Klempner,Thanh-Trang Vo, Andrea P. Myers, and Lewis C. Cantley
33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325
Saeed Rafii, Stan Kaye and Susana Banerjee
34 Targeting the c-Met Kinase, 341
Chad Tang, M. Angelica Cortez, David Hong, and James W. Welsh
35 KIT Kinase, 347
Scott E. Woodman
36 TP53, 353
Kensuke Kojima and Michael Andreeff
Part V Future Perspectives
37 Future Perspectives, 363
Rabih Said and Apostolia-Maria Tsimberidou
Index, 371
List of Contributors
James Abbruzzese, MD
Division of Medical Oncology
Duke Cancer Institute
Durham, NC, USA
Maen Abdelrahim, MD, PhD
Department of Internal Medicine
Baylor College of Medicine
Houston, TX, USA
Abass Alavi, MD, MD(Hon.), PhD(Hon.), DSc(Hon.)
Department of Radiology
Hospital of the University of Pennsylvania
Philadelphia, PA, USA
Kenneth C. Anderson, MD, PhD
LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology, Dana-Farber Cancer Institute
Harvard Medical School
Boston, MA, USA
Michael Andreeff, MD, PhD
Section of Molecular Hematology and Therapy
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Analia Azaro, MD
Early Clinical Drug Development Group
Vall d'Hebron Institute of Oncology
Universitat Autonoma de Barcelona
Barcelona, Spain
Susana Banerjee, MBBS, MA, MRCP, PhD
The Royal Marsden Hospital
London, UK
Robert C. Bast, MD
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Susanne H. C. Baumeister, MD
Department of Pediatric Oncology
Dana-Farber Cancer Institute
Boston, MA
Division of Hematology-Oncology
Boston Children's Hospital
Harvard Medical School
Boston, MA
Giada Bianchi, MD
LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center
Department of Medical Oncology, Dana-Farber Cancer Institute
Harvard Medical School
Boston, MA, USA
Patrick Boland, MD
Department of Medicine
Temple University School of Medicine
Philadelphia, PA, USA
Jessica L. Bowser, PhD
Department of Pathology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Russell R. Broaddus, MD, PhD
Department of Pathology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Harold J. Burstein, MD, PhD
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Harvard Medical School
Boston, MA, USA
Lewis C. Cantley, PhD
Meyer Cancer Center at Weill Cornell Medical College
New York, NY, USA
Robert L. Coleman, MD
Department of Gynecologic Oncology and Reproductive Medicine
Center for RNA Interference and Non-Coding RNA
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Anthony P. Conley, MD
Department of Sarcoma Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Jorge Cortes, MD
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
M. Angelica Cortez, PhD
Department of Experimental Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Carlo M. Croce, MD
Department of Molecular Virology, Immunology and Medical Genetics
Comprehensive Cancer Center
Ohio State University
Columbus, OH, USA
Jasmine Quynh Dao, MD
Children's Cancer Hospital
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
John F. de Groot, MD
Department of Neuro-Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Yves A. DeClerck, MD
Division of Hematology-Oncology
Department of Pediatrics and Department of Biochemistry and Molecular Biology
The Saban Research Institute of Children's Hospital Los Angeles
Los Angeles, CA, USA
Department of Medicine
Committee on Clinical Pharmacology and Pharmacogenomics
The University of Chicago
Chicago, IL, USA
Gianpiero Di Leva, PhD
Department of Molecular Virology, Immunology and Medical Genetics
Comprehensive Cancer Center
Ohio State University
Columbus, OH, USA
Glenn Dranoff, MD, PhD
Department of Medicine, Harvard Medical School
Human Gene Transfer Laboratory Core, Dana-Farber Cancer Institute
Boston, MA, USA
Hua Fang, PhD
Division of Hematology-Oncology
The Saban Research Institute of Children's Hospital Los Angeles
Los Angeles, CA, USA
Department of Medicine
Committee on Clinical Pharmacology and Pharmacogenomics
The University of Chicago
Chicago, IL, USA
Omotayo Fasan, MRCP
Department of Medicine
Temple University School of Medicine
Philadelphia, PA, USA
Department of Hematologic Oncology and Blood Disorders
Levine Cancer Institute
Charlotte, NC, USA
Keith T. Flaherty, MD
Massachusetts General Hospital Cancer Center
Boston, MA, USA
David Fogelman, MD
Department of Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Matthew D. Galsky, MD
Division of Hematology and Medical Oncology
The Tisch Cancer Institute
Mount Sinai School of Medicine
New York, NY, USA
Guillermo García-Manero, MD
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Benjamin A. Gartrell, MD
Department of Medical Oncology
Montefiore Medical Center
The Albert Einstein College of Medicine
Bronx, NY, USA
Gabriel Ghiaur, MD, PhD
The Sidney Kimmel Comprehensive Cancer Center
The Johns Hopkins University School of Medicine
Baltimore, MD, USA
Michael C. Haffner, MD
The Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute
The Johns Hopkins University School of Medicine
Baltimore, MD, USA
Roy S. Herbst, MD, PhD
Department of Medicine
Division of Medical Oncology
Yale Comprehensive Cancer Center
New Haven, CT, USA
Ashley M. Holder, MD
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
David Hong, MD
Department of Investigational Cancer Therapeutics
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Jean-Pierre J. Issa, MD
Fels Institute for Cancer Research and Molecular Biology
Temple University School of Medicine
Philadelphia, USA
Elias Jabbour, MD
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Nitin Jain, MD
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Preetesh Jain, MD, DM, PhD
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Filip Janku, MD, PhD
Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program)
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Milind Javle, MD
Department of Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Richard J. Jones, MD
The Sidney Kimmel Comprehensive Cancer Center
The Johns Hopkins University School of Medicine
Baltimore, MD, USA
Stan Kaye, MD
The Royal Marsden hospital and The Institute of Cancer Research
London, UK
Samuel J. Klempner, MD
Division of Hematology/Oncology
University of California Irvine Health
Orange, CA, USA
Birgit Knoechel, MD, PhD
Boston Children's Hospital
Dana-Farber Cancer Institute
Harvard Medical School
Boston, MA, USA
Kensuke Kojima, MD, PhD
Section of Molecular Hematology and Therapy
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Scott Kopetz, MD, PhD, FACP
Department of Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Patricia Kropf, MD
Department of Medicine
Temple University School of Medicine
Philadelphia, PA, USA
Razelle Kurzrock, MD
Center for Personalized Cancer Therapy
UC San Diego Moores Cancer Center
La Jolla, CA, USA
Jens G. Lohr, MD, PhD
Dana-Farber Cancer Institute
Boston, MA, USA
Harvard Medical School
Boston, MA, USA
David Menter, PhD
Department of Gastrointestinal Medical Oncology
The University of Texas MD Anderson Cancer...
