Transgenerational Epigenetics
Academic Press
2nd Edition
Published on 18. May 2019
518 pages
978-0-12-816733-5 (ISBN)
Description
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born.
This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
- Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer
- Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery
- Features chapter contributions from international experts
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05/2019
2nd Edition
Academic Press
€184.50
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Content
1. Generational epigenetic inheritance
SECTION I Definitions and history of generational epigenetic inheritance2. Definition of epigenetic transgenerational inheritance and biological impacts3. Historical perspective of transgenerational epigenetics
SECTION II Germline epigenetics4. Epigenetic changes in the mammalian paternal germ line
SECTION III Parental epigenetic inheritance5. Maternal epigenetic inheritance6. Paternal epigenetic inheritance
SECTION IV Basic mechanisms/processes of epigenetic inheritance7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice8. Histone-mediated transgenerational epigenetics9. Heritable generational epigenetic effects through small noncoding RNA10. Long noncoding RNA and epigenetic inheritance
SECTION V Model organisms11. Nonmammalian model organisms in epigenetic research:an overview12. Plant models of transgenerational epigenetic inheritance13. Epigenetics and heritable phenotypic variations in livestock14. Transgenerational epigenetic inheritance in insects
SECTION VI Evolution of transgenerational epigenetics15. Evolutionary perspectives on transgenerational epigenetics16. Inheritance of epigenome variants across generations during evolution
SECTION VII Environmental epigenetic effects on the offspring17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals18. Transgenerational effects of imprinting19. Epigenetic inheritance across multiple generations
SECTION VIII Impact of transgenerational epigenetics on disease20. Transgenerational epigenetics, paternal obesity, and insulin resistance21. Epigenetic inheritance of type 2 diabetes
SECTION IX Clinical significance of transgenerational epigenetics22. Clinical aspects of transgenerational epigenetics
