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Pharmacological Control of Heart and Circulation, Volume 1, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Because the papers published in this volume cover diverse areas of the cardiovascular field, they had to be arranged into several smaller symposia. The common thread running through these symposia is their focus on some pathological condition of the heart and circulation as well as on their control by drugs. The first symposium is devoted to the pharmacological control of the adverse effects of coronary insufficiency including disturbances in rhythm. The second symposium is dedicated to cardiac hypertrophy; to the action of cardiac hypertrophy on the sensitivity of the heart to drugs; and to the changes in the biochemical parameters of the myocardium due to cardiomegaly. The third symposium deals with hypertension and its pharmacological control. Two separate symposia are devoted to new drugs, namely the fourth symposium to the cerebrovascular activity of Cavinton-a synthetic Vinca-derivative; and the fifth to a newly developed beta-adrenergic blocking agent, Tobanum, to its anti-arrhythmic action, its effect in myocardial ischemia and in hypertension. Finally, a short symposium on serotonin and serotonin antagonists, both of great importance in cardiovascular pharmacology, is included.
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978-1-4831-4778-9 (9781483147789)
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PrefacePharmacological Control of the Adverse Effects of Coronary Insufficiency Pharmacological Control of the Adverse Effects of Coronary Insufficiency. Introduction Metabolic Changes Due to Myocardial Ischemia Effects of Ischemic Metabolites on the Mitochondrial Membrane Antianginal and Antiarrhythmic Agents and Cellular Components Effect of Myocardial Ischemia on the Basic Electrical Phenomena in the Heart Cell Arrhythmogenic Action of Local Myocardial Ischemia Significance of the Autonomic Nervous System in the Appearance of Arrhythmias Due to Coronary Occlusion Influence of Hypothyroidism on Cardiac Arrhythmias Induced by Coronary Occlusion Influence of Thyrotoxicosis on Disorders of Cardiac Rhythm Appearing in Coronary Insufficiency Acute Effect of Antiarrhythmic Drugs in Heart Rhythm Disturbances Due to Myocardial Ischemia Effect of Prolonged Treatment with Antiarrhythmic and Antianginal Drugs on the Incidence of Ventricular Fibrillation and Death in the Acute Phase of Myocardial Infarction in Awake Rats Effect of Pentobarbitone Anaesthesia, Age, and Sex in the Acute Phase of Myocardial Infarction in Rats Importance of Metabolic Changes in the Antianginal Effect of Drugs at the Subcellular Level Significance of Metabolic Alterations in the Effect of Antianginal Drugs at the Cellular Level Importance of Metabolic Changes in the Antianginal Action of Drugs at the Organ Level Role of Haemodynamics in the Antianginal Action of Drugs Effect of A Drug Combination in the Experimental Model of Angina Pectoris Effect of Drugs on Cerebral Circulation in Chronic Cerebral Ischemia Adrenergic Mechanisms in Coronary Vascular Control and Oxygen Metabolism Following Brief Regional Myocardial IschemiaCardiac Hypertrophy Changes in the Contractility and Catecholamine-Sensitivity of Myocardium in Isoproterenolinduced Cardiac Hypertrophy The Role of Thyroid stage in the Inotropic Effect of Adenosine on Ventricular Myocardium Alteration of Catecholamine-Sensitivity in Thyroxine-Induced Myocardial Hypertrophy Regulation of ß-Adrenergic Receptors in Heart Muscle. Some Aspects Investigation on the Altered Properties of Myosin Associated with Cardiac Hypertrophy Biochemical Parameters Related to Cardiomegaly Studies on the Myosin ATPase Activity in Experimentally-Induced Cardiac Hypertrophy in Rats Cardiac Arrhythmias Induced by Electrical and Chemical Stimulation of Some Hypothalamic Nuclei in the RatsHypertension-Pharmacological and Clinical Aspects An Analysis of Antihypertensive Drugs Pharmacologic Control of Hypertensive Emergencies Some Studies on the Central Actions of Beta-Adrenoreceptor Blocking Drugs in Man Mode of Action of Centrally Acting Antihypertensive Drugs The Influence of Hypotensive Drugs on Adaptive Haemodynamic Reactions The Cardiovascular Pattern of Clonidine-like Antihypertensive Substances and Their Mode of Action Involvement of Presynaptic and Postsynaptic a-Adrenoceptors in the Action of Clonidine-like Substances Tachyphylaxis to the Hypo Tensive Effect of Clonidine on Rats Hypertensive Effect of Clonidine and Regional Noradrenaline Concentration in the Brain of Normotensive and Hypertensive Rats after Acute and Chronic Treatment The Effect of Indomethacin on Renin-Angiotensin-Aldosterone System in Essential Hypertension Cross-over Trial for Comparing Antihypertensive Effects of Prazosin and Hydralazine Taurine and Hypertension Planning of Antihypertensive Pyridazine Compounds Pharmacology of GYKI-11.679, a New Antihypertensive Drug The Antihypertensive Effect of Morpholino-Pyridazinyl-Hydrazine and Its Hydrazone Derivative Pharmacological Control of Disseminated Intravascular Coagulation (DIC)The Beta-Adrenergic Blocker Tobanum® Pharmacology of GYKI-41099 (Chlorpropanol, Tobanum®).