Systemic Sclerosis
1st Edition
Published on 4. February 2016
VIII, 247 pages
978-4-431-55708-1 (ISBN)
Description
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
More details
Series
Language
English
Place of publication
Tokyo
Japan
Publishing group
Springer Tokyo
Target group
Professional and scholarly
Product notice
Reflowable
Illustrations
VIII, 247 p. 28 illus., 21 illus. in color.
File size
4,21 MB
ISBN-13
978-4-431-55708-1 (9784431557081)
DOI
10.1007/978-4-431-55708-1
Schweitzer Classification
Other editions
Additional editions
Kazuhiko Takehara | Manabu Fujimoto | Masataka Kuwana
Systemic Sclerosis
Basic and Translational Research
Book
02/2016
Springer
€106.99
Shipment within 10-15 days
Persons
Dr. Kazuhiko Takehara
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
Dr. Manabu Fujimoto
Department of Dermatology, University of Tsukuba, Japan
Dr. Masataka Kuwana
Department of Allergy and Rheumatology, Nippon Medical School, Japan
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
Dr. Manabu Fujimoto
Department of Dermatology, University of Tsukuba, Japan
Dr. Masataka Kuwana
Department of Allergy and Rheumatology, Nippon Medical School, Japan
Content
1.- Fibrosis: overview 2.- Autoimmunity in systemic sclerosis: Overview 3.- Endothelial progenitor cell 4.- Animal models of systemic sclerosis 5.- Genetics of Systemic Sclerosis 6.- Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7.- Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8.- Epigenetics 9.- Transforming Growth Factor-ß and Connective Tissue Growth Factor 10.- Endothelin 11.- The Role of B cells in Systemic Sclerosis 12.- Fli1 13.- Biomarker 14.- Autoantibodies in Systemic Sclerosis
