Therapeutic Targeting of RAS Mutant Cancers
Published on 30. September 2022
978-1-009-08102-3 (ISBN)
Description
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
More details
Other editions
Additional editions
Edward C. Stites | Kendra Paskvan | Shumei Kato
Therapeutic Targeting of RAS Mutant Cancers
Book
09/2022
Cambridge University Press
€24.00
Shipment within 15-20 days
