Molecular And Cellular Approaches To The Control Of Proliferation And Differentiation

ContributorsPrefaceI Regulation of Cell Proliferation 1 Growth Factors: Their Role in the Control of Cell Proliferation I. Growth Factors and Receptors II. Signal Transduction III. Growth-Related Gene Expression IV. Concluding Remarks References 2 Nuclear Protooncogenes and Growth Regulation I. Introduction II. Expression of Nuclear Protooncogenes during Proliferation III. Properties of Nuclear Protooncogenes IV. Functional Significance of Nuclear Protooncogene Expression during Cell Proliferation V. Molecular Mechanisms of Proliferation Control by Nuclear Protoocogenes VI. Regulation of Nuclear Protooncogene Expression VII. Summary References 3 The Control of Mitotic Division I. Introduction II. The Cell Biological Approach to the Study of Mitosis III. The Genetic Approach IV. The Biochemical Approach V. The Immunological Approach VI. The Current Model for Mitotic Regulation References 4 Cell Cycle and Cell-Growth Control I. Introduction: A Historical Overview of the Cell Cycle II. The Prereplicative Phase of the Cell Cycle III. G0-G1: Dividing versus Nondividing States IV. Changes Associated with the G0-G1 Transition and Gx Progression V. Nutrient-Related Control Points within G1 VI. Molecular Control Points within G1 VII. Modulation of Cell Growth by Modulation of Growth-Associated Gene Expression VIII. Conclusion References 5 Regulation of Gene Expression by Serum Growth Factors I. Introduction II. Growth Factor-Regulated Gene Expression and Growth Control III. Signal-Transduction Pathways IV. Transcriptional and Posttranscriptional Control V. Proteins Encoded by Immediate-Early Genes VI. Delayed-Early Gene Expression and Cell Cycle Progression VII. Activation of Immediate-Early Genes by Other Signaling Agents VIII. Summary and Conclusion ReferencesII Cellular, Biochemical, and Molecular Parameters of in vitro Model Systems in Which Modifications in Cell-Growth Control Are Functionally Related to the Onset of Differentiation 6 Gene Expression during Development of the Osteoblast Phenotype: An Integrated Relationship of Cell Growth to Differentiation I. Introduction II. The Growth-Differentiation Relationship III. Conclusion References 7 Growth and Differentiation of Myelomonocytic Cells I. Introduction II. Cell Lines as Models of Myelomonocytic Differentiation III. Cytokines and Their Receptors IV. Signal Transduction V. Gene Activation VI. Concluding Remarks References 8 Erythroleukemia Cells I. Overview of Murine Erythroleukemia Cell Differentiation II. Effect of HMBA on Cell Cycle Progression and Globin Transcription III. Agents Active as Inducers of Differentiation and Inhibitors of Differentiation IV. Role of Proteins Affecting Cell Cycle Progression in the Induction of MELC Differentiation V. Summary: Relationship of the Cell Cycle to Commitment to Terminal Erythroid Differentiation References 9 Growth and Differentiation in Melanocytes I. Introduction II. Genetic Approaches to Studying Melanocyte Growth and Differentiation III. Factors Reported to Modulate Melanocyte Growth and Differentiation in vitro IV. Concluding Remarks ReferencesIII Exploring Mechanisms of Control 10 Molecular Mechanisms That Mediate a Functional Relationship between Proliferation and Differentiation I. Two Transition-Restriction Points during Development of the Osteoblast Phenotype Characterize the Proliferation-Differentiation Relationship II.