Current Topics in Cellular Regulation

The Role of GTP-Binding Proteins in Signal Transduction: From the Sublimely Simple to the Conceptually Complex I. Introduction II. Discovery of the Role of GTP in Signal Transduction III. Contemporary View of G-Protein Structure and Actions IV. Mechanochemical Basis for Signal Transduction V. Speculations and Perspectives ReferencesActivation of Cholera Toxin by ADP-Ribosylation Factors, 20-kDa Guanine Nucleotide-Binding Proteins I. Introduction II. ADP-Ribosyltransferase and NAD Glycohydrolase Activities of Cholera Toxin III. Biochemical Characterization of ADP-Ribosylation Factors IV. Activation of Escherichia coli Heat-Labile Enterotoxins by ADP-Ribosylation Factors V. Immunological Characterization of ADP-Ribosylation Factors VI. Molecular Characterization of ADP-Ribosylation Factors VII. Perspectives ReferencesSignal Transduction by the Colony-Stimulating Factor-1 Receptor; Comparison to Other Receptor Tyrosine Kinases I. Introduction II. Brief Overview of the Biological Actions of CSF-1 and Its Receptor III. Structure of CSF-1R and Relationship to Other Receptor Tyrosine Kinases IV. Biosynthesis of CSF-1R V. Mechanism of Ligand Activation in RTKs VI. Role of Autophosphorylation in RTKs VII. Intracellular Substrates of RTKs VIII. Regulation of RTKs IX. Ligand Induction of Gene Expression and Mitogenesis X. Conclusions ReferencesThe Secretory Granule and the Mechanism of Stimulus-Secretion Coupling I. Introduction II. The Mast Cell and Its Secretory Granules III. The Mechanism of Granule Activation IV. The Simultaneous Events of Granule Activation V. A New Model for the Mechanism of Stimulus-Secretion Coupling VI. Conclusions ReferencesCalcium Pumps in the Plasma and Intracellular Membranes I. The Plasma Membrane Ca2+ Pump II. The Ca2+ Pump of the Sarcoplasmic Reticulum III. Pathology of Ca2+ Pumps IV. General Common Features of Ca2+ Pumps ReferencesProtein Phosphorylation in Translational Control I. Introduction II. Initiation Factors III. Elongation Factors IV. mRNP Proteins V. Ribosomal Proteins VI. Aminoacyl-tRNA Synthetases VII. Protein Phosphatases Involved in the Dephosphorylation of Translational Components ReferencesIndex