Immunotherapy: a Review and Update
Published on 30. January 2021
283 pages
978-1-77407-892-1 (ISBN)
Description
Immunotherapy refers to harnessing the immune system to treat cancer and infectious diseases. The immune system is robust enough to fight microbes and also perform what is termed as immune surveillance or checking for any alterations in cells. The idea of immunotherapy is hence simple-it activates the immune system to target pathogens or cancer cells. Given these interesting aspects, this book covers the history and basics of immunotherapy. Apart from discussing the approaches, the aspects of challenges are presented. These include honing the specificity and the cost of the therapy. Potential solutions to overcome these challenges have been presented. Thus, a reader can read this concise book that presents the fundamentals of immunotherapy without getting overwhelmed.
More details
Language
English
Place of publication
Oakville
Canada
Target group
Professional and scholarly
File size
13,89 MB
ISBN-13
978-1-77407-892-1 (9781774078921)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Content
- Cover
- Copyright
- DECLARATION
- ABOUT THE EDITORS
- TABLE OF CONTENTS
- List of Contributors
- List of Abbreviations
- Preface
- Chapter 1 History of Immunotherapy
- 1.1 Introduction
- 1.2 Immune System
- 1.3 Therapies based on Anti-bodies
- 1.4 Immunosuppression and reduction in treatment
- 1.5 Cancer Vaccines
- 1.6 Using viruses to heal
- 1.7 Final points
- 1.8 References
- Chapter 2 Immunotherapy: Looking at the Details
- 2.1 The basics
- 2.2 Overview of Immunotherapy
- 2.3 Antibodies and Tumor-specific monoclonal antibodies (mAbs)
- 2.4 Cytokines for Treatment
- 2.5 Oncolytic Viruses
- 2.6 Dendritic Cells and Immunotherapy
- 2.7 PRR Agonists
- 2.8 Immune Checkpoint Inhibitors:
- 2.9 Vaccines
- 2.10 Adoptive Cell Transfer (ACT) Strategies
- 2.11 Other Approaches
- 2.12 Summary
- 2.13 References
- Chapter 3 Summarizing The Challenges and Solutions
- 3.1 Looking at Consistenc
- 3.2 Identification of Clinically Significant Biomarkers - the Inherent Difficulties
- 3.3 Requirement for an Increased Number of Predictive Biomarkers
- 3.4 Efficacy being Impeded by Tumor Heterogeneity
- 3.5 Resistance to Drug Treatment - Development
- 3.6 Efficacy Evaluation Needs Distinct Clinical Study Designs
- 3.7 Cancer Immunotherapy Drugs - An Expensive Proposition
- 3.8 The Challenges and Solutions
- 3.9 The way Ahead
- 3.10 References
- Chapter 4 Extracorporeal Photo-Immunotherapy for Circulating Tumor Cells
- Abstract
- Introduction
- Materials and Methods
- Results
- Discussion
- References
- Chapter 5 A Platform for Designing Genome-Based Personalized Immunotherapy or Vaccine against Cancer
- Abstract
- Introduction
- Results
- Discussion
- Conclusion
- Methods
- References
- Chapter 6 Immunotherapy In Gastrointestinal Cancers
- Abstract
- Gastrointestinal Cancers: Where Do We Stand?
- The Rationale For Immunotherapy In Gi Cancers
- Immunotherapeutic Strategies: A General Overview
- Focus On Gastric, Esophageal, and Pancreatic Cancers
- Focus on Colorectal Cancer
- Focus on Hepatocellular Carcinoma
- Possible Biomarkers For Immunotherapy: The Pathologist Perspective
- Back To The Bench: Biomarkers And Genetic Signatures as Predictive Factors
- Future Perspectives
- References
- Chapter 7 Harnessing the Microbiome to Enhance Cancer Immunotherapy
- Abstract
- Introduction
- Coley's Toxin In Tumor Immunotherapy
- Commensal Microflora Regulates The Innate and Adaptive Immune System
- Toll-Like Receptors in Cancer Immunotherapy
- Tlr Expression on T Cells and Cancer Cells
- Vaccines Promote Weak T Cell-Mediated Tumor Regression
- Act Therapy: A Promising Cancer Treatment
- Lymphodepletion Augments Act Therapy
- Mechanisms Of Tbi Effectiveness: Sinks, Suppressors, and Microbial Activators
- Lymphodepletion Activates The Innate Immune System
- Mimicking Tbi: Promoting The Benefits While Removing The Harm
- Potentiating Antitumor T Cells: Costimulation, Cytokines, and Microbial Signals
- Intestinal Microbiota Affects Adjuvant Therapy (Cpg And Il-10 Blockade)
- Cd4+ T Cells For Act: Microbes Enhance Th17 Cells
- Microbiota-Targeted Therapies To Treat Cancer Patients
- Concluding Remarks
- Acknowledgments
- References
- Chapter 8 Aptamers: A Feasible Technology in Cancer Immunotherapy
- Abstract
- Introduction
- Aptamer Development/Selex
- Aptamer-Based Immunotherapy
- Concluding Remarks
- References
- Chapter 9 Immunotherapy In The Precision Medicine Era: Melanoma And Beyond
- Breakthroughs In Melanoma
- Genomics-Guided Advances
- Future Of Precision Immunotherapy
- References
- Chapter 10 Advances and Prospects in Cancer Immunotherapy
- Abstract
- Introduction
- Cancer Development
- Interactions Between Cancer and The Immune System
- Cytokine And Anticytokine Therapy
- Antibody Therapy
- Vaccination
- Adoptive Cell Therapy (Act)
- Prospects In Cancer Immunotherapy
- References
- Index
- Back Cover
