
Immunotherapy: a Review and Update
Description
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Content
- Cover
- Copyright
- DECLARATION
- ABOUT THE EDITORS
- TABLE OF CONTENTS
- List of Contributors
- List of Abbreviations
- Preface
- Chapter 1 History of Immunotherapy
- 1.1 Introduction
- 1.2 Immune System
- 1.3 Therapies based on Anti-bodies
- 1.4 Immunosuppression and reduction in treatment
- 1.5 Cancer Vaccines
- 1.6 Using viruses to heal
- 1.7 Final points
- 1.8 References
- Chapter 2 Immunotherapy: Looking at the Details
- 2.1 The basics
- 2.2 Overview of Immunotherapy
- 2.3 Antibodies and Tumor-specific monoclonal antibodies (mAbs)
- 2.4 Cytokines for Treatment
- 2.5 Oncolytic Viruses
- 2.6 Dendritic Cells and Immunotherapy
- 2.7 PRR Agonists
- 2.8 Immune Checkpoint Inhibitors:
- 2.9 Vaccines
- 2.10 Adoptive Cell Transfer (ACT) Strategies
- 2.11 Other Approaches
- 2.12 Summary
- 2.13 References
- Chapter 3 Summarizing The Challenges and Solutions
- 3.1 Looking at Consistenc
- 3.2 Identification of Clinically Significant Biomarkers - the Inherent Difficulties
- 3.3 Requirement for an Increased Number of Predictive Biomarkers
- 3.4 Efficacy being Impeded by Tumor Heterogeneity
- 3.5 Resistance to Drug Treatment - Development
- 3.6 Efficacy Evaluation Needs Distinct Clinical Study Designs
- 3.7 Cancer Immunotherapy Drugs - An Expensive Proposition
- 3.8 The Challenges and Solutions
- 3.9 The way Ahead
- 3.10 References
- Chapter 4 Extracorporeal Photo-Immunotherapy for Circulating Tumor Cells
- Abstract
- Introduction
- Materials and Methods
- Results
- Discussion
- References
- Chapter 5 A Platform for Designing Genome-Based Personalized Immunotherapy or Vaccine against Cancer
- Abstract
- Introduction
- Results
- Discussion
- Conclusion
- Methods
- References
- Chapter 6 Immunotherapy In Gastrointestinal Cancers
- Abstract
- Gastrointestinal Cancers: Where Do We Stand?
- The Rationale For Immunotherapy In Gi Cancers
- Immunotherapeutic Strategies: A General Overview
- Focus On Gastric, Esophageal, and Pancreatic Cancers
- Focus on Colorectal Cancer
- Focus on Hepatocellular Carcinoma
- Possible Biomarkers For Immunotherapy: The Pathologist Perspective
- Back To The Bench: Biomarkers And Genetic Signatures as Predictive Factors
- Future Perspectives
- References
- Chapter 7 Harnessing the Microbiome to Enhance Cancer Immunotherapy
- Abstract
- Introduction
- Coley's Toxin In Tumor Immunotherapy
- Commensal Microflora Regulates The Innate and Adaptive Immune System
- Toll-Like Receptors in Cancer Immunotherapy
- Tlr Expression on T Cells and Cancer Cells
- Vaccines Promote Weak T Cell-Mediated Tumor Regression
- Act Therapy: A Promising Cancer Treatment
- Lymphodepletion Augments Act Therapy
- Mechanisms Of Tbi Effectiveness: Sinks, Suppressors, and Microbial Activators
- Lymphodepletion Activates The Innate Immune System
- Mimicking Tbi: Promoting The Benefits While Removing The Harm
- Potentiating Antitumor T Cells: Costimulation, Cytokines, and Microbial Signals
- Intestinal Microbiota Affects Adjuvant Therapy (Cpg And Il-10 Blockade)
- Cd4+ T Cells For Act: Microbes Enhance Th17 Cells
- Microbiota-Targeted Therapies To Treat Cancer Patients
- Concluding Remarks
- Acknowledgments
- References
- Chapter 8 Aptamers: A Feasible Technology in Cancer Immunotherapy
- Abstract
- Introduction
- Aptamer Development/Selex
- Aptamer-Based Immunotherapy
- Concluding Remarks
- References
- Chapter 9 Immunotherapy In The Precision Medicine Era: Melanoma And Beyond
- Breakthroughs In Melanoma
- Genomics-Guided Advances
- Future Of Precision Immunotherapy
- References
- Chapter 10 Advances and Prospects in Cancer Immunotherapy
- Abstract
- Introduction
- Cancer Development
- Interactions Between Cancer and The Immune System
- Cytokine And Anticytokine Therapy
- Antibody Therapy
- Vaccination
- Adoptive Cell Therapy (Act)
- Prospects In Cancer Immunotherapy
- References
- Index
- Back Cover
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