
Rossi's Principles of Transfusion Medicine
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Transfusion Medicine impacts patients with hematologic, oncologic, and surgical conditions as well as all areas of critical care medicine and multiple areas of chronic care. This book aims to be the single best source for information related to any aspect or application of Transfusion Medicine.
Contributors for the sixth edition have once again been drawn from various scientific, medical, and surgical disciplines. Thus, this book ranges from encouraging and managing donors, to collecting and preserving the blood, to matching it to the appropriate recipient, all the way to its clinical uses. It also extends these concepts to implantable tissue and regenerative medicine. Other sample topics covered within the work include:
* Contemporary issues in donation and transfusion: patient blood management, clinical and technical aspects of blood administration, and donor and patient Hemovigilance
* Blood components and derivatives: red blood cell metabolism, preservation and oxygen delivery, blood groups, and composition of plasma
* Apheresis, transplantation, and new therapies: hematopoietic growth factors, therapeutic phlebotomy and cellular apheresis, HLA antigens, alleles, and antibodies
* How Transfusion Medicine has been affected by the coronavirus pandemic, the role of pathogen reduction and other modern trends
This book serves as a complete and comprehensive resource on Transfusion Medicine for clinicians who prescribe blood, students who expect to enter clinical practice, and for the scientists, physicians, nurses, technologists, and others who assure the quality and availability of blood services.
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Persons
Toby L. Simon, MD is Senior Medical Director for Plasma and Plasma Safety with CSL Plasma and in Research and Development for the parent company CSL Behring, He is past-president of AABB and America's Blood Centers. He has been on the faculty of University of New Mexico School of Medicine (currently clinical faculty), Medical Director of TriCore Reference Laboratories and industry representative to the FDA Blood Products Advisory Committee.
Eric A. Gehrie, MD is a clinical pathologist who specializes in blood banking/transfusion medicine. He is currently the Executive Physician Director over Direct Patient Care and Emerging Cell and Gene Therapy Solutions at the American Red Cross. He has previously been on the faculty of both Yale and Johns Hopkins University Schools of Medicine. He is a member of the editorial board of Transfusion.
Jeffrey McCullough, MD is Professor Emeritus at the University of Minnesota Medical School with experience in both hospital transfusion services and blood centers. He was the editor of Transfusion for 15 years and the founding president of the US National Marrow Donor Program. He is currently an international advisor in transfusion medicine. He is past-president of the American Board of Pathology.
John D. Roback, MD, PhD is a Professor in the Department of Pathology and Laboratory Medicine at Emory University. His appointments include Medical Director of Emory Medical Laboratories, Emory/Children's Laboratory for Innovative Assay Development, and the Center for Transfusion and Cellular Therapies. He is also Executive Vice-Chair of Clinical Operations. He is a former editor of the AABB Technical Manual.
Edward L. Snyder, MD, FACP is Professor of Laboratory Medicine and Attending Physician in the Transfusion and Tissue Services at Yale Medical School/Yale New Haven Hospital. He is also the blood bank director at Bridgeport Hospital. He is past chair of the BeTheMatch Board of Directors and is a past-president of AABB. He is an associate editor of Transfusion and past-recipient of Emily Cooley, Morton Grove-Rasmussen and presidential awards from AABB.
Content
Contributors
Preface
List of abbreviations
Section I: Transfusion medicine from ancient times to the current pandemic
Chapter 1. Transfusion in the new millennium - Ennio C. Rossi and Toby L. Simon
Chapter 2. Disaster and the blood community (including COVID-19)-Ruth Sylvester and Louis M. Katz
Chapter 3. Responding to the Regulatory Challenges during Emergencies and Epidemics- Peter Mark Section II: Blood donation
Chapter 4 Recruitment and screening of donors and the collection of blood-Susan Rossmann, Mary Townsend and Toby L. Simon
Chapter 5 Blood donor testing-Jed B. Gorlin and Nancy Van Buren
Chapter 6 Acute adverse reactions after blood donation- Anne F. Eder
Chapter 7 Chronic effects of blood and plasma donation-Bryan Spencer and T. Simon
Chapter 8 Global perspective: ensuring blood and blood product safety and availability through regulation and certification-Eva D. Quinley
Section III: Blood groups and pretransfusion testing
Chapter 9 Carbohydrate blood groups- Laura Cooling
Chapter 10 Rh and LW blood group antigens- Connie M. Westhoff, Don L. Siegel, and Aline Floch
Chapter 11 Other protein blood groups- Jill Storry and Jennifer Ricci Hagman
Chapter 12 Molecular and routine compatibility testing-Connie Westhoff
Section IV: Blood components
Part A. Red cells
Chapter 13 Red blood cell production and kinetics-Mark J. Koury and Lionel Blanc
Chapter 14 Red cell metabolism, preservation and oxygen delivery-John Hess and Angelo D'Alessandro
Part B: Platelets
Chapter 15 Platelet production and kinetics- Christopher A. Tormey, Henry M. Rinder, and Thomas C. Binns
Chapter 16 Platelet immunology and alloimmunization- Cheryl L. Maier and Seema R. Patel and H. Clifford Sullivan
Chapter 17 Preparation, preservation, and storage of platelet concentrates- Moritz Stolla and Valery J. Li and Johnathan P. Mack
Part C: White cells
Chapter 18 Neutrophil production and kinetics: neutropenia and neutrophilia- Lawrence Rice and Eric Salazar
Chapter 19 Granulocyte collection and transfusion- Jeffrey McCullough, Corrinne Goldberg and Jenny Petkova
Part D: Plasma
Chapter 20 Composition of plasma - Peter Hellstern
Chapter 21 Plasma and cryoprecipitate for transfusion including SD plasma- Simon Stanworth and Toruma Apelseth
Chapter 22 The purification of plasma proteins for therapeutic use- Nathan Brinkman, Karl McCann, and Barry Gooch
Chapter 23 Immunoglobulins Products- Melvin Berger
Section V: Apheresis
Chapter 24 Basic principles of apheresis and the collection of blood components by apheresis- Jeffrey L. Winters and Edwin A. Burgstaler
Chapter 25 Therapeutic apheresis: Plasma processing - Patricia A.R. Brunker and Monica B. Pagano
Chapter 26 Therapeutic phlebotomy and specialized hemapheresis- Patricia Brunker and Jeffey Bailey
Section VI: Blood transfusion
Chapter 27 Patient blood management- Darrell J. Triulzi and Jansen N. Seheult and
Mark H. Yazer and Jonathan H. Waters
Chapter 28 Clinical and technical aspects of blood administration - Edward S. Lee, Debra L. Mraz, and Edward L. Snyder
Chapter 29 Anemia and RBC transfusion- Jeff Carson
Chapter 30 Sickle cell disease, thalassemia, and hereditary hemolytic anemias-Ross M. Fasano, Emily Riehm Meier and Satheesh Chonat
Chapter 31 Autoimmune hemolytic anemias and paroxysmal nocturnal hemoglobinuria-Christopher A. Tormey and Alexa J. Siddon
Chapter 32 Hemolytic disease of the fetus and newborn- Megan Delaney, Wen Lun, Jennifer Webb
Chapter 33 Obstetric transfusion practice- Roback
Chapter 34 Transfusion in Infants and Children-Jeanne E. Hendrickson and Cassandra D. Josephson
Chapter 35 Thrombocytopenia and platelet transfusion-Michael F. Murphy, Lise J Estcourt and Simon J. Stanworth
Chapter 36 Immune mediated Thombocytopenia- Theodore Warkentin, Donald Arnold, Ishac Nazi, and James W. Smith
Chapter 37 Coagulation Concentrates for Inherited Bleeding Disorders-Robert F. Sidonio and Gary M. Woods
Chapter 38 Coagulation factor concentrates and pharmacologic therapies for acquired bleeding disorders- Ravi Sarode and Natalie Bavli
Chapter 39 Perioperative transfusion practice- James R. Stubbs, Allan Klompas, and Leanne Thalji
Chapter 40 Transfusion therapy in the care of trauma and burn patients- John R. Hess, Eileen M. Bulger, Benjamin Huebner, and Samuel Mandell
Chapter 41 Transfusion support for the oncology patient- Kristin M. Stendahl, Wade L. Schulz, Edward L. Snyder
Chapter 42 Pathogen reduction of blood components- Snyder and McCullough
Section VII: Adverse sequelae of transfusion
Chapter 43 Hemovigilance: weighing transfusion risks and benefits- Scott Kopesell
Chapter 44 Transfusion transmitted virus infections-Erhard Seifried
Chapter 45 Transfusion transmission of parasites and prions - Bryan Spencer and Paula Saa
Chapter 46 Bacterial Contamination of Blood Components- Evan M. Bloch, Richard J. Benjamin and Sandra Ramirez
Chapter 47 Hemolytic transfusion reactions- Celina Montemayor Garcia and Sandhya R. Panch
Chapter 48 Febrile, allergic, and nonimmune transfusion reactions- Emmanuel A. Fadeyi and Gregory J. Pomper
Chapter 49 Transfusion-related lung injury- Ulrich Sachs and Johnathan P. Wallis
Chapter 50 Transfusion-associated graft-versus-host disease- Eric A. Gehrie and Courtney E. Lawrence
Chapter 51 Transfusion-associated iron overload- Sujit Sheth
Section VIII: Cellular and tissue transplant technologies
Chapter 52 Hematopoetic growth factors and Cytokines-David Kuter
Chapter 53 Hematopoetic stems cells and transplantation- Garrett S. Booth
Chapter 54 HLA antigens, alleles, and antibodies-Harold Clifford Sullivan, Robert A. Bray, Howard M. Gebel and Scott M. Krummey
Chapter 55 Car-T cells and other cellular immunotherapies- Don Siegel and Andrew Fesnak
Chapter 56 Gene therapy applications to transfusion medicine-Diane S. Krause, Seena Tabibi, Emanuela M. Bruscia and Eric A. Gehrie
Chapter 57 Tissue engineering and regenerative medicine-Julie G. Allickson
Chapter 58 Human Tissue Allografts: Following the Path from Donor to Recipient - Matthew J. Kuehnert and Cassandra D. Josephson
Index
List of contributors
Julie Allickson
Mayo Clinic, Center for Regenerative Medicine, Rochester, MN, USA
Torunn Oveland Apelseth
Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen; and Norwegian Armed Forces Medical Services, Oslo, Norway
Donald M. Arnold
Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Jeffrey A. Bailey
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA
Natalie Bavli
Department of Internal Medicine (Hematology/Oncology), University of Texas Southwestern, Dallas, TX, USA
Richard J. Benjamin
Cerus, Concord, CA, USA and Department of Laboratory Medicine, Georgetown University Washington, DC, USA
Melvin Berger
Departments of Pediatrics and Pathology, Case Western Reserve University, Cleveland, OH, USA
Thomas C. Binns
Departments of Pathology and Laboratory Medicine, Yale School of Medicine and Yale New Haven Hospital, New Haven, CT, USA
Lionel Blanc
Division of Pediatrics Hematology/Oncology, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell and Feinstein Institutes for Medical Research, Manhasset, NY, USA
Evan M. Bloch
Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Garrett S. Booth
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
Robert A. Bray
Department of Pathology, Emory University Hospital, Atlanta, GA, USA
Nathan Brinkman
CSL Behring, Bradley, IL, USA
Patricia A. R. Brunker
Blood Transfusion Service, Department of Pathology, Massachusetts General Hospital, Harvard University, Boston, MA, USA
Emanuela M. Bruscia
Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, CT, USA
Eileen M. Bulger
Trauma Center, Department of Surgery, Harborview Medical Center, University of Washington, Seattle, WA, USA
Edwin A. Burgstaler
Therapeutic Apheresis Treatment Unit, Mayo Clinic, Rochester, MN, USA
Jeffrey L. Carson
Division of General Internal Medicine, Rutgers Biomedical Health Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Satheesh Chonat
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
Laura Cooling
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Angelo D'Alessandro
Department of Biochemistry and Molecular Genetics; and Metabolomics Core (SOM and Cancer Center), University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA
Meghan Delaney
Children's National Hospital, and Departments of Pediatrics and Pathology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
E. Alexander Dent
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA
Anne F. Eder
Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD; and Georgetown University Medical Center, Washington, DC, USA
Lise J. Estcourt
NHS Blood and Transplant, Department of Haematology, Oxford University Hospitals and University of Oxford, Oxford, UK
Emmanuel A. Fadeyi
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Ross M. Fasano
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine; and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
Andrew D. Fesnak
Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Aline Floch
Univ Paris Est Créteil, INSERM U955, IMRB, Etablissement français du sang Ile-de-France, Créteil, France
Caroline Gabe
Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Faculty of Medicine, University of São Paulo, São Paulo, Brazil
Howard M. Gebel
Department of Pathology, Emory University Hospital, Atlanta, GA, USA
Eric A. Gehrie
The American Red Cross, Biomedical Services Division, Baltimore, MD, USA
Corinne Goldberg
The American Red Cross, Biomedical Services Division, Durham, NC, USA
Barry Gooch
CSL Behring, King of Prussia, PA, USA
Jed B. Gorlin
Innovative Blood Resources and Community Blood Center of Greater Kansas City, Divisions of New York Blood Center Enterprises, St. Paul, MN, USA
Laura Green
NHS Blood and Transplant and Barts Health NHS trust, London; Queen Mary University of London, London, UK
Jennifer Ricci Hagman
Department of Clinical Immunology and Transfusion Medicine, Division of Laboratory Medicine, Office for Medical Services; and Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
Paul C. Hébert
Medicine and Palliative Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
Peter Hellstern
Center of Hemostasis and Thrombosis Zurich, Zurich, Switzerland
Jeanne E. Hendrickson
Departments of Laboratory Medicine and Pediatrics, Yale University School of Medicine, New Haven, CT, USA
John R. Hess
Laboratory Medicine and Pathology and Hematology, University of Washington School of Medicine; and Transfusion Service, Harborview Medical Center, Seattle, WA, USA
Benjamin R. Huebner
Surgical Critical Care, Harborview Medical Center, University of Washington, Seattle, WA, USA
Cassandra D. Josephson
Departments of Pathology and Pediatrics, Center for Transfusion and Cellular Therapies, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA
Louis M. Katz
ImpactLife Blood Services, Davenport, IA and Medicine and Infectious Diseases, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Allan M. Klompas
Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
Scott Koepsell
University of Nebraska Medical Center, Omaha, NE, USA
Daryl J. Kor
Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
Mark J. Koury
Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
Diane S. Krause
Department of Laboratory Medicine and the Yale Stem Cell Center, Yale School of Medicine, Yale University, New Haven, CT, USA
Scott M. Krummey
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
Matthew J. Kuehnert
Musculoskeletal Transplant Foundation, Edison, NJ, USA; and Department of Medicine, Hackensack Meridian School of Medicine, Hackensack, NJ, USA
David J. Kuter
Hematology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Courtney E. Lawrence
Department of Pediatrics and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Edward S. Lee
Department of Laboratory Medicine, Yale University School of Medicine; and Blood Bank, Yale-New Haven Hospital, New Haven, CT, USA
Valery J. Li
Bloodworks Northwest Research Institute, Seattle; University of Washington School of Medicine, Seattle, WA, USA
Wen Lu
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
Johnathan P. Mack
The Ottawa Hospital/Ottawa Hospital Research Institute, University of Ottawa, ON, Canada
Cheryl L. Maier
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Samuel P. Mandell
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, WA, USA
Peter W. Marks
Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA
Karl McCann
CSL Behring, Broadmeadows, Victoria,...
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