Current Topics in Membranes and Transport
Molecular Biology of Ionic Channels
Published on 1. January 1989
444 pages
978-0-08-058504-8 (ISBN)
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Current Topics in Membranes and Transport
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Felix Bronner | A. Kleinzeller
Current Topics in Membranes and Transport: v. 33
Book
12/1988
Academic Press
€129.59
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Content
- Front Cover
- Molecular Biology of Ionic Channels
- Copyright Page
- Contents
- Preface
- Yale Membrane Transport Processes Volumes
- Chapter 1. Ion Channels of Paramecium, Yeast, and Escherichia coli
- I. Paramecium
- II. Yeast
- III. Escherichia coli
- IV. Conclusion
- References
- PART I: GRAMlClDlN
- Chapter 2. Gramicidin: Conclusions Based on the Kinetic Data
- I. Introduction
- II. Gramicidin Forms Pores
- III. Selectivity
- IV. The Evidence That the Pore Is a Dimer
- V. Structural Inferences from the Kinetic Data
- VI. Ion Conduction through the Pore
- VII. Conclusions
- References
- Chapter 3. Gramicidin, a "Simple" Ion Channel
- Text
- References
- Chapter 4. Ion Interactions with the Gramicidin a Transmembrane Channel: Cesium-133 and Calcium-43 NMR Studies
- I. Introduction
- II. Cesium Ion Transport Studies
- III. Calcium Ion Interaction Studies
- IV. Appendix
- References
- Chapter 5. Ion Transport through Transmembrane Channels: Ab Initio Perspectives
- I. Introduction
- II. Theoretical Approaches
- III. Ab Initio Methods-General Considerations
- IV. Oramicidin
- V. Applications
- VI. Summary
- References
- Chapter 6. Rapid Gating Events and Current Fluctuations in Gramicidin A Channels
- I. Introduction
- II. Methods
- III. Properties of Gaps in Channel Currents
- IV. Open-Channel Noise
- V. Conclusions
- References
- PART II: NICOTINIC ACETYLCHOLINE RECEPTORS
- Chapter 7. Function of Mammalian Nicotinic Acetylcholine Receptors: Agonist Concentration Dependence of Single Channel Current Kinetics
- I. Introduction
- II. Methods
- III. Results and Discussion
- References
- Chapter 8. Regulation of the Nicotinic Acetylcholine Receptor Channel by Protein Phosphorylation
- I. Protein Phosphorylation
- II. The Nicotinic Acetylcholine Receptor
- III. Protein Phosphorylation of the Nicotinic Acetylcholine Receptor
- IV. Conclusions
- References
- Chapter 9. Synthetic Peptides in the Study of the Nicotinic Acetylcholine Receptor
- I. Overview
- II. Synthetic Peptides in the Application of Inmunochemical Tests of AChR Structure
- III. Functional Activities Associated with Synthetic Peptides
- IV. Determination of the Solution Conformation of Small Synthetic Peptides Relevant to the Ligand-Binding Site of the AChR
- References
- Chapter 10. Expression of Acetylcholine Receptor Subunits in Saccharomyces cerevisiae (Yeast)
- Text
- References
- Chapter 11. Establishing a Stable Expression System for Studies of Acetylcholine Receptors
- I. Introduction
- II. Materials and Methods
- III. Results
- IV. Discussion
- References
- PART III: VOLTAGE-SENSITIVE SODIUM CHANNELS
- Chapter 12. Molecular Characteristics of Sodium Channels in Skeletal Muscle
- I. Introduction
- II. Biochemistry of Skeletal Muscle Sodium Channels
- III. Functional Reconstitution of the Purified Sodium Channel
- IV. Channel Primary Sequence
- V. Probing Channel Topography
- VI. Sodium Channel Subtypes
- VII. Summary
- References
- Chapter 13. Electrical Recordings from Cloned Sodium Channels Expressed In Xenopus Oocytes
- Text
- References
- Chapter 14. Tissue-Specific Expression of Genes Encoding the Rat Voltage-Gated Sodium Channel
- I. Introduction
- II. Ontogeny of Sodium Channel Type I and Type II in Rat Brain
- III. Tissue-Specific Expression of Sodium Channel Type II
- IV. Discussion
- References
- Chapter 15. A Model Relating the Structure of the Sodium Channel to Its Function
- I. Introduction
- II. Model of Sodium Channel Transmembrane Segments
- III. Tertiary Structure
- IV. Experimental Tests
- V. Conclusions
- References
- Chapter 16. Sodium Channels in Lipid Bilayers: Have We Learned Anything Yet?
- I. Introduction
- II. The Method
- III. Interaction of Guanidinium Toxins
- IV. Fixed Surface Charge
- V. Two Not Totally Speculative Proposals
- References
- Chapter 17. Voltage-Sensitive Sodium Channels: Molecular Structure and Function
- I. Na Channels as Proteins
- II. Protein Structure and Channel Gating
- III. Function of the Purified Protein
- IV. Chemical Modifications That Alter Regulation of Ion Conductance
- V. Conclusion
- References
- PART IV: CALCIUM CHANNELS
- Chapter 18. Molecular Properties of Voltage-Sensitive Calcium Channels
- I. Introduction
- II. Identification and Purification of Calcium Channels from Skeletal Muscle
- III. Functional Properties of the Purified Calcium Antagonist Receptor in Phospholipid Vesicles
- IV. Subunit Structure of Dihydropyridine-Sensitive Calcium Channel
- V. Immunospecific Identification of Calcium Channel Components in Other Tissues
- VI. Conclusion
- References
- Chapter 19. Cardiac Calcium Channels: Pore Size and Symmetry of Energy Profile
- I. Introduction
- II. A Model for the Ca Channel: A Single-File Pore with Two Binding Sites
- III. Recordings in Intact Cells to Estimate Pore Size
- IV. Recordings in Planar Bilayers
- V. Discussion
- References
- PART V: CONCLUSION
- Chapter 20. ?-Conotoxins and Voltaga-Sensitive Calcium Channel Subtypes
- I. Introduction
- II. The ?-Conotoxins and Their Receptor Targets
- III. Discussion
- References
- Index
- Contents of Recent Volumes
