Current Topics in Membranes and Transport
Published on 16. December 1985
328 pages
978-0-08-058496-6 (ISBN)
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Current Topics in Membranes and Transport
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12/1985
Academic Press
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Content
- Front Cover
- Regulation of Calcium Transport across Muscle Membranes
- Copyright Page
- Contents
- Contributors
- Preface
- Yale Membrane Transport Processes Volumes
- Chapter 1. Overall Regulation of Calcium Transport in Muscle
- I. Introduction
- II. Regulation of Calcium Transport in Plasma Membrane
- III. Regulation of Calcium Transport in Subcellular Organelles
- IV. Cellular Ion Regulation and Disease
- References
- PART I: REGULATION OF CALCIUM TRANSPORT IN PLASMA MEMBRANES
- Chapter 2. Sarcolemmal Enzymes Mediating ß-Adrenergic Effects on the Heart
- I. Introduction
- II. Brief Synopsis of Sarcolemmal Activities Mediating ß-Adrenergic Effects on the Heart
- III. Isolation and Characterization of Cardiac Sarcolemmal Vesicles
- IV. ß-Adrenergic Receptors in Purified Cardiac Sarcolemmal Vesicles
- V. Adenylate Cyclase Activity in Purified Cardiac Sarcolemmal Vesicles
- VI. Cyclic AMP-Dependent Protein Kinase Activity in Purified Cardiac Sarcolemmal Vesicles
- VII. Phosphoprotein Substrates in Purified Cardiac Sarcolemmal Vesicles
- Vlll. Conclusions
- References
- Chapter 3. Properties of Myocardial Calcium Slow Channels and Mechanisms of Action of Calcium Antagonistic Drugs
- I. Introduction
- II. Special Properties of the Myocardial Slow Channels
- III. Blockade of Slow Channels by Calcium Antagonists
- IV. Summary and Conclusions
- References
- Chapter 4. The Sarcolemmal Sodium-Calcium Exchange System
- I. Introduction
- II. Historical Aspects
- III. Stoichiometry
- IV. Kinetics
- V. Regulation of the Sodium-Calcium Exchange System
- VI. Identification of the Cardiac Sodium-Calcium Exchange Protein
- VII. Sodium-Calcium Exchange and the Regulation of Myocardial Contractility
- VIII. Concluding Remarks
- References
- PART II: REGULATION OF CALCIUM TRANSPORT IN SUBCELLULAR ORGANELLES
- Chapter 5. Regulation of Calcium Transport in Cardiac Sarcoplasmic Reticulum
- I. Introduction
- II. Effect of Phospholamban on Kinetics of Ca2 + Transport and Ca2+,Mg2+ -ATPase
- III. Characterization and Purification of Ca2+ ,Mg2+ -ATPase
- IV. Characterization and Purification of Phospholamban
- V. Characterization of the Functional Association between Ca2+ ,Mg2+ -ATPase, Phospholamban, and Calmodulin in Cardiac SR
- VI. Reconstitution of the Ca2+ ,Mg2+ -ATPase with the 22,000-Da Protein in the Absence of Phosphate
- VII. Reconstitution of the Ca2+,Mg2+ -ATPase with the 22,000-Da Protein in the Presence of Phosphate
- VIII. Concluding Remarks
- References
- Chapter 6. Role of Calmodulin in the Regulation of Muscle Contraction
- I. Introduction
- II. Characterization of Calmodulin
- III. Functions of Calmodulin in Muscle
- IV. Calmodulin in the Regulation of Ca2+ Influx into Cytosol: Calmodulin-Dependent Phosphorylation of Skeletal Sarcoplasmic Reticulum Proteins
- V. Calmodulin in the Regulation of Calcium Efflux from the Cytosol
- VI. Calmodulin-Dependent Protein Phosphatases
- VII. Concerted Regulation of Ca2 + Fluxes by Ca2+ and cAMP
- VIII. Conclusion
- References
- Chapter 7. Calcium Release from Sarcoplasmic Reticulum
- I. Introduction
- II. Physiological Release of Ca from the SR
- III. Various Modes of Ca Release from the SR
- IV. Physiological Significance of Various Ca Release Mechanisms
- References
- Chapter 8. The Regulation of Mitochondrial Calcium Transport in Heart
- I. Introduction
- II. The Ca2+ Uniporter
- III. The Na+-Ca2+ Carrier
- IV. The Na+-Independent Efflux of Ca2+
- V. The Na+-H+ Antiporter
- VI. Ca2+ Recycling
- VII. The Kinetic Regulation of Mitochondrial Ca2+
- VIII. The Effects of Catecholamines and Glucagon on Ca2+ Transport by Isolated Mitochondria
- IX. The Regulation of Mitochondrial Ca2+ by Catecholamines in Vivo
- References
- PART III: CELLULAR ION REGULATION AND DISEASE
- Chapter 9. Cellular Ion Regulation and Disease: A Hypothesis
- I. Introduction
- II. General Cellular Responses to Injury
- III. Progression and Mechanism of Change in Acute Lethal Injury
- IV. Ion Regulation in Cell Injury
- V. Control of Division and Differentiation
- VI. Summary
- References
- Index
- Contents of Recent Volumes
