Modulation by Covalent Modification

ContributorsForewordPrefaceThressa C. StadtmanEarl R. StadtmanI. Principles of Coordination and Amplification 1. Cyclic Cascade Systems in Metabolic Regulation 2. Sensitivity of Metabolic Fluxes to Covalent Control 3. The Coordinated Control of Metabolic Pathways by Broad-Specificity Protein Kinases and PhosphatasesII. Phosphorylation and Dephosphorylation 4. Regulation of Mammalian Pyruvate and Branched-Chain a-Keto Acid Dehydrogenase Complexes by Phosphorylation-Dephosphorylation 5. The Mechanism of Regulation of Smooth Muscle Myosin by Phosphorylation 6. Protein Phosphorylation and Translational Control in Reticulocytes: Activation of the Heme-Controlled Translational Inhibitor by Calcium Ions and Phospholipid 7. Insulin-Dependent Tyrosine Protein Kinase: Cellular Distribution and Copurification with the Insulin Receptor 8. Insulin-Stimulated Phosphorylation of Actin by Human Placental Insulin Receptor Preparations 9. Microtubule Cytoskeletal Proteins as Targets for Covalent Interconverting Enzymes 10. Regulation of cAMP-Dependent Protein Kinase in Cultured Cells 11. NMR Studies of the Mechanism of Action and Regulation of Protein Kinase 12. The Role of Protein Kinase in the Lens 13. Regulation of Yeast Fructose-1,6-Bisphosphatase by Phosphorylation-Dephosphorylation 14. The Role of Substrate Structure in Recognition and Regulation of Enzymatic Interconversion of Proteins 15. Subunit Structure and Regulation of Phosphorylase Phosphatase 16. Comparisons of the Changes of Sulfation and Phosphorylation in MalignancyIII. Adenylylation, Uridylylation, and ADP-Ribosylation 17. Adenylylation of Bacterial Glutamine Synthetase: Physiological Significance 18. The Role of Uridylyltransferase and PII in the Regulation of the Synthesis of Glutamine Synthetase in Escherichia coli 19. The Role of Adenylyltransferase and Uridylyltransferase in the Regulation of Glutamine Synthetase in Escherichia coli 20. In Situ Regulation Studies of Escherichia coli Glutamine Synthetase 21. Altered Regulation of Adenylate Cyclase After Toxin-Catalyzed ADP-Ribosylation 22. 3-Deoxy-D-Glycero-Pentos-2-ulose, A Novel Pentose Derived from Poly(ADP-Ribosyl) HistonesIV. Proteolysis 23. cAMP-Triggered Proteolysis of cAMP-Dependent Protein Kinase in Brush Border Membranes 24. Posttranslational Processing of the Insulin Proreceptor 25. Regulation of Mammalian Cytosolic Ca2+-Requiring Neutral Proteinases 26. Covalent Modification of Proteins by Mixed Function Oxidation 27. Modification of Yeast Fructose-1,6-Bisphosphatase 28. Production and Utilization of Reactive Oxidants by Neutrophils 29. Inactivation of Enzymes by Activated Human Neutrophils 30. Molecular Basis of Intracellular Regulation of Thiol Proteinase Inhibitors 31. Structural and Enzymatic Properties of Escherichia coli Glutamine Synthetase Subjected to Limited Proteolysis 32. Involvement of the Stringent Response in Regulation of Protein Degradation in Bacillus subtilis 33. Regulation of Mitochondrial Protein Concentration: A Plausible Model Which May Permit Assessing Protein TurnoverV. Role of Signaling Metabolites 34. Fructose 2,6-Bisphosphate Versus Cyclic AMP in the Liver and in Lower Eukaryotic Cells 35. Fructose 2,6-Bisphosphate and Enzymatic Activities for Its Metabolism in Ascites Tumor 36. The Calmodulin Regulatory System 37. Mode of Calcium Activation of Calmodulin-Regulated Enzymes 38. Mechanism of Enzyme Regulation by Calmodulin and Ca2+ 39. Functional and Regulatory Importance of Calcium-Mediated Hydrophobic Regions of Calmodulin, Protein Kinase C, and Other Calcium-Binding ProteinsVI. Selenium in Cellular Metabolism 40. The Glutathione Peroxidase Reaction: Molecular Basis of the Antioxidant Function of Selenium in Mammals 41.