The Immune System

List of ContributorsPrefaceAcknowledgmentsI. V Region: Structure and Genetics-Molecular Basis of Antibody Specificity Antibody Structure and the Immune Response The Three-Dimensional Structure of the Antigen Binding Site of McPC 603 Protein Kinetic Mapping of Antibody Binding Sites Multispecificity of the Antibody Combining Region and Antibody Diversity Polyfunctional Antibody Combining RegionsII. V Region: Structure and Genetics-Genetic Control of Variable Region Structure A Study of V Region Genes Using Allotypic and Idiotypic Markers First Order Considerations in Analyzing the Generator of Diversity Antibody Diversity: An AssessmentIII. Lymphocyte Membranes and Surface Receptors-Molecular Characterization Molecular and Functional Properties of Lymphocyte Surface Immunoglobulin Alloantiserum Induced Blockade of IR Gene Product Function Further Characterization of Ia (Immune Response Region Associated) Antigen Molecules Receptors for Antigen on "b, T, B-T and NUL" Lymphocytes in Normal and "NUDE" Mice Cytophilic Properties of T Lymphocyte Membrane Associated Immunoglobulins In-Vitro Biosynthesis and Molecular Arrangement of Surface Immunoglobulin of Mouse Thymus CellsIV. Lymphocyte Membranes and Surface Receptors-Effects of Ligand Binding at the Cell Surface The Lymphocyte Plasma Membrane Probing Lymphocyte Membrane Organization Polyclonal Mitogens and the Nature of B Lymphocyte Activation MechanismsV. B-Cell Activities-Molecular Genetics: mRNA Control and Mutations The Organization of Immunoglobulin Genes Quantitative Estimation of the mRNA for H-Chain Immunoglobulin Mutations in Mouse Myeloma Cells Spontaneous Mutation in Immunoglobulin GenesVI. B-Cell Activities-Development and Propagation of Clones Biography of the B Cell The Generation of Diversity within Single Clones of Antibody-Forming Cells B Memory Cells in the Propagation of Stable Clones of Antibody-Forming Cells Antigen Dependence of Clonal MemoryVII. T Cell Effects on Other Cells-Suppressor T Cells Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide by Thymic-Derived Cells Thymocyte Subpopulation with Suppressive Activity Suppressor T Cells in Low Zone Tolerance Antibody Induced Suppressor T-Cells T Cell Regulation: The "Second Law of Thymodynamics"VIII. T Cell Effects on Other Cells-Mediators and Matrices T Cell Factors in the Regulation of the B Cell Response Antigen Specific T Cell Factors and Their Role in the Regulation of T-B Interaction The Nature of the Signals Required for the Induction of Antibody Synthesis Idiotypic Receptors for Alloantigen on T Cells?IX. On-Off Signals: Cellular Discrimination and Genetic Control Manipulation of a Tolerant State: Cells and Signals The Role of Histocompatibility Gene Products in Cooperative Cell Interactions between T and B Lymphocytes Ir Genes and Antigen Recognition