Dynamics of Bone and Cartilage Metabolism

PART I Components of the Organic Extracellular Matrix of Bone and Cartilage1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone2. Fibrillogenesis and Maturation of Collagens3. Vitamin K Dependent Proteins of Bone and Cartilage4. Non-collagenous Proteins; Glycoproteins and Related Proteins5. Proteoglycans and Glycosaminoglycans6. Growth Factors7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules9. Alkaline Phosphatases10. Acid Phosphatases11. Matrix Proteinases PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage12. Mineralization, Structure and Function of Bone13. Bone Structure and Strength14. The Cells of Bone15. Signalling in bone16. Parathyroid Hormone: Structure, Function and Dynamic Actions17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology19. Sex Steroid Effects on Bone Metabolism20. Physiology of Calcium and Phosphate Homeostasis21. The Central Control of Bone Remodelling22. New Concepts in Bone Remodeling23. Products of Bone Collagen Metabolism24. Supramolecular Structure of Cartilage Matrix25. Products of Cartilage Metabolism26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products27. Transgenic Models of Bone Disease PART III Markers of Bone and Cartilage Metabolism28. The Role of Genetic Variation in Osteoporosis29. Measurement of Calcium, Phosphate and Magnesium30. Measurement of Parathyroid Hormone 31. New Horizons for Assessment of Vitamin D Status in Man32. Measurement of Biochemical Markers of Bone Formation33. Measurement of Biochemical Markers of Bone Resorption34. Variability in the measurement of biochemical markers of bone turnover35. Validation of Biochemical Markers of Bone Turnover36. Genetic Markers of Joint Disease37. Body Fluid Markers of Cartilage Metabolism38. Laboratory Assessment of Postmenopausal Osteoporosis39. Monitoring of Anabolic Treatment40. Monitoring of anti-resorptive treatment41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover42. Osteoporosis in Men 43. Steroid-Induced Osteoporosis44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment45. Secondary Osteoporosis46. Osteomalacia and Rickets47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy48. Primary Hyperparathyroidism 49. Paget's Disease of Bone50. Metastatic Bone Disease51. Rare Bone Diseases52. Osteogenesis Imperfecta53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies54. Osteoarthritis and Degenerative Spine Pathologies