Genetic Effects on Environmental Vulnerability to Disease
Published on 15. September 2008
232 pages
978-0-470-69679-8 (ISBN)
Description
Much research has attempted to show direct linear relations betweengenes and disorder. However, scientists have been discouraged byinconsistent findings based on this simple gene-phenotype approach.The alternative approach is to incorporate information about theenvironment. A gene-environment interaction approach assumes thatenvironmental pathogens cause disorder, whereas genes influencesusceptibility to environmental pathogens.
This book brings together contributions from experts frommultiple disciplines who discuss:
* How epidemiological cohort studies can better integratephysiological (mechanistic) measures;
* How best to characterise subjects' vulnerability versusresilience by moving beyond single genetic polymorphisms;
* How gene hunters can benefit from recruiting samples selectedfor known exposures;
* How environmental pathogens can be used as tools for genehunting;
* How to deal with potential spurious (statistical) interactions,and
* How genes can help explain fundamental demographic propertiesof disorders (e.g. sex distribution, age effects).
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M. Novartis Rutter
Novartis Foundation 293 - Genetic Effects on Environmental Vulnerability to Disease
Software
08/2008
Wiley
€62.06
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Book
06/2008
Wiley
€112.00
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Person
Prof Sir Michael Rutter, King's College, London, UK
Prof Rutter is the leading child psychiatrist in the UK. He set up the MRC Child Psychiatry Research Unit and the Institute of Psychiatry's Social, Genetic and Developmental Psychiatry Centre. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002.?He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President.
He has published extensively.
Content
1. Michael Rutter
Introduction: whither gene-environment interactions?
2. Rudolf Uher
Gene-environment interaction: overcoming methodologicalchallenges
Discussion
3. Marco Battaglia, Cecilia Marino, Michel Maziade, MassimoMolteni and Francesca D'Amato
Gene-environment interaction and behavioural disorders: adevelopmental perspective based on endophenotypes
Discussion
4. Naomi R. Wray, William L. Coventry, Michael R. James,Grant W. Montgomery, Lindon J. Eaves and Nicholas G.Martin
Use of monozygotic twins to investigate the relationship between5HTTLPR genotype, depression and stressful life events: anapplication of Item Response Theory
Discussion
Appendix
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J. H. Penninx, Harriëtte Riese and Catharina A.Hartman
Role of gene-stress interactions in gene-findingstudies
Discussion
6. Kenneth A. Dodge
Practice and public policy in the era of gene-environmentinteractions
Discussion
7. Kristi B. Adamo and FrédériqueTesson
Gene-environment interaction and the metabolicsyndrome
Discussion
General discussion II
8. Stephen P. Robertson and RichiePoulton
Longitudinal studies of gene-environment interaction incommon diseases--good value for money?
Discussion
9. Kee-Seng Chia
Gene-environment interactions in breast cancer
Discussion
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, SarahRowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches tounderstanding how gene-environment interactions work topredict susceptibility and outcomes of infections
Discussion
11. Steven R. Kleeberger and Hye-YounCho
Gene-environment interactions in environmental lungdiseases
Discussion
General discussion III
12. Fernando D. Martinez
Gene-environment interaction in complex diseases: asthmaas an illustrative case
Discussion
13. Michael Rutter
Conclusions: taking stock and looking ahead
Glossary
Index of contributors
Subject index
