
Late-Life Depression
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Content
- Intro
- Contents
- Contributors
- Introduction
- PART I: EPIDEMIOLOGY AND THE BURDEN OF ILLNESS
- 1. The Epidemiology of Depressive Disorders in Late Life
- Case Identification
- Prevalence, Incidence, and Distribution
- Prognosis
- Historical Trends
- Use of Psychiatric Services
- 2. The Social and Financial Burden of Late-Life Depression to Society and Individuals
- Mortality
- Co-Morbidity and Disability
- Health-Care Service and Resource Use
- Suicide and Late-Life Depression
- PART II: THE PHENOMENOLOGY AND DIFFERENTIAL DIAGNOSIS OF LATE-LIFE MOOD DISORDERS
- 3. Unipolar Depression
- Diagnosing Late-Life Depression
- Other Syndromes of Late-Life Depression
- Assessment
- Course and Consequences of Late-Life Depression
- Medical Co-Morbidity
- Cognitive Impairment Disorders
- Disability
- Suicide
- Barriers to Effective Recognition and Treatment of Geriatric Unipolar Depression
- 4. Bipolar Disorders
- Historical Perspective
- Diagnosis
- Differential Diagnosis of Mania in Late Life
- Epidemiology
- Pathophysiology and Etiology
- Features of Episodes: Psychopathology and Its Assessment
- Cognitive Impairment
- Function/Behavioral Disability
- Course of Illness: Chronicity
- Course of Illness: Relapse and Recurrence
- Course of Illness: Suicide
- Course of Illness: Psychiatric Services Use and Caregiver Burden
- Modification of the Course by Other Age-Associated Factors
- Nonaffective Outcomes
- Response to Antimanic Treatment
- Response to Antidepressant Treatment in Bipolar Depression
- Relapse and Recurrence in Maintenance Treatment
- 5. Dysthymic Disorder in the Elderly
- Prevalence
- Diagnosis
- Age-at-Onset
- Co-Morbidity
- Family History
- Social Adjustment, Quality of Life, and Disability
- Prognosis
- Dysthymic Disorder in Primary Care
- Rating Scales
- Neurobiology
- Treatment
- Long-Term Response and Relapse
- Antipsychotic Medications
- Psychotherapy
- 6. Nonmajor Clinically Significant Depression in the Elderly
- Nosological and Diagnostic Complexities
- Historical Perspective
- Stability of Syndromes and Psychiatric Diagnoses
- Differential Diagnosis: Minor Depression
- Differential Diagnosis: Subsyndromal Depressive Spectrum
- Differential Diagnosis: Other Diagnostic Categories
- Does Geriatric Nonmajor Clinically Significant Depression Differ from Depression in Younger Adults?
- Epidemiology and Clinical Features
- Genetics
- Neuroimaging, and Neuropsychological and Polysomnographic Studies
- Treatment
- 7.Mixed Cognitive and Depressive Syndromes
- Depression in Dementia
- Putative Common Neurobiological Mechanisms of Dementia and Depression
- Cerebrovascular Disease and Depression in Dementia
- Cognition in Late-Life Depression
- Is "Pseudodementia" Real?
- Neuropsychological Studies of Cognition in Late-Life Depression
- Cognitive Impairment Associated with Subclinical Cerebrovascular Disease in Late-Life Depression
- Other Markers of Cognitive Impairment and Decline in Geriatric Depression: Neuropsychological Measures
- Other Markers: Structural Neuroimaging
- Other Markers: Functional Neuroimaging
- Other Markers: Genetic Markers
- Other Markers: Stress Hormones and Other Peripheral Biochemical Markers
- Course and Outcome of Depression with Cognitive Impairment
- Effects of Antidepressant Treatment on Cognitive Functions
- Diagnosis and Differential Diagnosis
- 8. Suicide
- Methodological Issues
- Prevalence of Suicidal Behaviors in Late Life
- Neurobiology of Late-Life Suicide
- Mental Health
- Physical Health and Function
- Social Factors
- Access to Lethal Means
- Summary of Risk
- Approaches to Prevention
- Universal Prevention
- Selective Prevention
- Indicated Prevention
- 9.Bereavement and Depression
- Stages
- Psychological and Somatic Depressive Symptoms and Course of Bereavement
- Physical Symptoms, Substance Use, and Medical Treatment
- Mortality
- Psychiatric Disorders-Depression, Anxiety, and Mania
- Complicated or Traumatic Bereavement
- Predictors of Pathological Outcomes
- Treatment
- PART III: THE PSYCHOBIOLOGY OF LATE-LIFE DEPRESSION
- 10. Neuropsychological Assessment of Late-Life Depression
- The Effect of Age on Neuropsychological Functioning: Age-Appropriate Cognitive Decline
- Profile of Depression-Associated Cognitive Decline
- Attention
- Verbal Processing
- Visuospatial Processing
- Memory
- Processing Speed
- Executive Functioning
- The Interaction of Age and Depression on Neuropsychological Functioning
- The Interaction of Age-at-Onset and Depressive Cognitive Decline
- Neuropsychological Assessment of Late-Life Depression
- 11. Structural and Functional Brain Imaging in Late-Life Depression
- Brain Structural Abnormalities: Magnetic Resonance Imaging Hyperintensities
- Clinical Correlates
- Etiology of Encephalomalacia
- Longitudinal Perspective
- Volumetric Brain Structural Abnormalities: Ventricular Enlargement and Sulcal Prominence
- Brain Structural Morphometry
- Functional Brain Abnormalities
- Treatment and Recovery Effects in Late-Life Depression
- 12. Late-Life Depression and the Vascular Hypothesis
- Development of Concepts Relating Brain Structural Change and Depression
- Risk Factors for Hyperintensities
- Lesion Location and Geriatric Depression
- Depression Outcomes of Patients with Vascular Brain Changes
- Lesions and Electroconvulsive Therapy Outcome
- Executive Dysfunction and Vascular Depression
- Cognitive Outcomes of Geriatric Depression
- Cognitive Outcomes of Vascular Depression
- Apolipoprotein E and Cognition
- Morbidity and Mortality Outcomes of Vascular Depression
- Leukoaraiosis and Lacunar Stroke: Apparently Different Outcomes
- Conceptual Framework
- Hippocampus and Geriatric Depression
- 13. Hypothalamic-Pituitary-Adrenal Axis Activity in Mood and Cognition in the Elderly: Implications for Symptoms and Outcomes
- Regulation and Function of the Hypothalamic-Pituitary-Adrenal Axis
- Hypothalamic-Pituitary-Adrenal Axis and Depression
- Geriatric Depression, Cognition, and Hypothalamic-Pituitary-Adrenal Activity
- Aging and Hypothalamic-Pituitary-Adrenal Activity
- Depression, Dementia, and Hypothalamic-Pituitary-Adrenal Activity
- Brain Structures in Cognition and Depression
- Frontal Lobe
- Limbic and Fronto-Striatal Connections
- Hippocampus and Amygdala
- Depression, Aging, and Mortality
- 14. The Neuroendocrinology of Aging
- Hormones and Neuropsychiatry
- Central Nervous System Mechanisms of Hormonal Action
- Age-Related Changes in Hormone Axes
- Carbohydrate Metabolism
- Parathyroid
- Hypothalamic-Pituitary-Thyroid Axis
- Hypothalamic-Pituitary-Adrenal Axis
- Dehydroepiandrosterone
- Growth Hormone
- Prolactin
- Female Hypothalamic-Pituitary-Gonadal Axis
- Male Hypothalamic-Pituitary-Gonadal Axis
- Depression and Neuroendocrine Dysregulation in the Elderly
- Hormonal Axis Dysregulation and Late-Life Depression
- Hypothalamic-Pituitary-Adrenal Axis, Depression, and Age
- Dehydroepiandrosterone, Depression, and Age
- Hypothalamic-Pituitary-Thyroid Axis, Depression and Age
- Hypothalamic-Pituitary-Gonadal Axis, Depression, and Age
- Testosterone and Male Neuropsychiatric Functioning
- Male Depressive Illness, Hypothalamic-Pituitary-Gonadal Axis Functioning, and Age
- PART IV: TREATMENT
- 15. Pharmacokinetics and Pharmacodynamics in Late Life
- Age-Associated Physiological Changes
- Pharmacokinetics
- Pharmacodynamics
- 16. Antidepressant Medication for the Treatment of Late-Life Depression
- Moderators and Mediators of the Antidepressant Response
- Antidepressant Medications
- Tricyclic Antidepressants
- Selective Serotonin Reuptake Inhibitors
- Fluoxetine
- Sertraline
- Paroxetine
- Citalopram
- Selective Serotonin Reuptake Inhibitor Side Effect Profile in Geriatric Patients
- Other Antidepressants
- Placebo versus Comparator Controlled Trials
- 17. Antidepressant Side Effects
- The Increased Likelihood of an Elderly Person Developing Side Effects
- Receptor Mechanisms of Antidepressant Side Effects in the Elderly
- Cardiovascular Side Effects
- Vascular Side Effects
- Falls
- Inappropriate Antidiuretic Hormone Secretion
- Weight Alterations
- Medication Noncompliance as a Risk for Antidepressant Adverse Events
- 18. Mood Stabilizers
- The Prevention of Depression in Elderly Bipolar Patients
- Difficulties in Conducting Studies of Mood Stabilizers in Elderly Patients
- Evidence of Spectrum of Efficacy, Tolerability, and Dosing
- Effects of Other Disorders on Lithium Efficacy and Tolerability
- Effects of Lithium on Organ Systems
- Valproate Use in Elderly Patients
- 19.Stimulants
- History
- Pharmacology
- Mechanism of Action
- Evidence for the Efficacy of Stimulants in Depression
- Stimulants for Augmentation
- Dextroamphetamine versus Methylphenidate
- Development of Tolerance during Depression Treatment
- Abuse Potential
- Side Effects
- 20. Antipsychotics
- Principles of Antipsychotic Use
- Antipsychotics in Depressive Disorders
- Antipsychotic Treatment Issues in the Elderly
- 21. Electroconvulsive Therapy in Late-Life Depression
- Use and Indications
- When to Consider Electroconvulsive Therapy
- Efficacy
- Medical Complications and Relative Contraindications
- Cognitive Side Effects
- 22. Pharmacological Treatment of Depression in Alzheimer's Disease
- Tricyclic Antidepressants
- Selective Serotonin Reuptake Inhibitors
- Monoamine Oxidase Inhibitors
- Newer Antidepressant Agents
- Electroconvulsive Therapy
- Guidelines for Treatment
- 23. Psychotherapy in Old-Age Depression: Progress and Challenges
- Rationale for Psychosocial Interventions and for Psychotherapy in the Treatment of Depression in Later Life
- Cognitive-Behavioral Therapy
- Interpersonal Psychotherapy
- Dialectical Behavior Therapy
- Psychotherapeutic Management of Suicidal Older Adult Patients
- Other Psychosocial Interventions
- 24. Treatment of Depression in Residential Settings
- The Context: Nursing Homes in America
- The Regulatory Environment
- Clinical Psychiatry in the Nursing Home
- Evolution in the Epidemiology of Depression and Its Treatment
- Delivery of Clinical Care
- PART V: DEPRESSION CO-MORBID WITH OTHER ILLNESSES
- 25. Depression Co-Morbid with Ischemic Heart Disease
- Depression in Patients with Cardiac Disease
- Depression and Development of Coronary Artery Disease
- The Effect of Depression on Cardiac Outcomes in Patients with Ischemic Heart Disease
- Physiological Mechanisms Underlying the Relationship Between Vascular Disease and Depression
- Depression and Sudden Cardiovascular Death
- Treatment of Depression in Patients with Ischemic Heart Disease
- The Cardiovascular Effects of Tricyclic Antidepressants
- The Antiarrhythmic Effect of Tricyclic Antidepressants: Cardiac Risk Reconsidered
- Tricyclic Antidepressants, Heart Rate Variability, and Cardiac Death
- The Cardiovascular Effects of the Selective Serotonin Reuptake Inhibitors
- Other Antidepressants
- Psychotherapy
- 26. Vascular Disease and Late-Life Depression: Stroke
- Historical Perspective
- Diagnosis of Poststroke Depression
- Prevalence of Depression
- Duration of Depression
- Relationship to Lesion Variables
- Premorbid Risk Factors
- Poststroke Depression and Activities of Daily Living
- Poststroke Depression and Cognitive Impairment
- Poststroke Depression and Mortality
- Mechanism of Poststroke Depression
- Treatment of Poststroke Depression
- 27. Substance Abuse Co-Morbidity
- Defining Co-Morbidity
- The Epidemiology of Late-Life Addictions
- The Co-Occurrence of Late-Life Depression and Use of Addictive Substances
- Diagnostic Considerations
- Treatment Issues
- 28. Basal Ganglia Disease and Depression
- Introduction to Basal Ganglia Disease
- Anatomy and Connections of the Basal Ganglia
- The Neuroanatomy of Depression
- Parkinson's Disease
- Huntington's Disease
- Wilson's Disease
- Parkinson-Plus Syndromes and the Tauopathies
- 29. Major Depressive Disorder in Alzheimer's Disease
- Neuropathological and Neurochemical Correlates of Major Depressive Disorder in Alzheimer's Disease
- Mechanism(s) of Neuronal Death in Alzheimer's Disease
- Discussion
- Epilogue
- Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- K
- L
- M
- N
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- P
- Q
- R
- S
- T
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- W
- X
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