Cancer of the Skin E-Book

Name: Cancer of the Skin E-Book | Expert Consult
Brand: Saunders
Price: 136.99 EUR
Availability: OnlineOnly

Expert Consult

Darrell S. Rigel Robert Friedman June K. Robinson Merrick I. Ross Clay J. Cockerell Henry Lim Eggert Stockfleth John M. Kirkwood(Author)

Saunders (Publisher)

2nd Edition

Published on 9. June 2011

720 pages

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978-1-4377-3614-4 (ISBN)

€136.99incl. 7% vat

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Content

Front Cover
Cancer of the skin
Copyright
Instructions for online access
Contents
Foreword
Preface
List of Contributors
Dedication & Acknowledgements
Chapter 1 : The Biology of Skin Cancer Invasion and Metastasis
Introduction
Mechanisms Of Cancer Growth And Metastasis
Cancer Stem Cells And Proliferation
Future Outlook
References
Chapter 2 : Genetics of Skin Cancer
Introduction
Basal Cell Carcinoma
Squamous Cell Carcinoma
Cutaneous Malignant Melanoma
Future Outlook
References
Chapter 3 : The Biology of the Melanocyte
Introduction
History
Structure And Function Of The Melanocyte
Structure And Function Of The Melanosome
Melanin Biosynthesis And Its Regulation
Future Outlook
References
Chapter 4 : Skin Cancer: Burden of Disease
Introduction
Melanoma
Non-Melanoma Skin Cancer
Future Trends
References
Chapter 5 : Epidemiology of Skin Cancer
Introduction
History
Descriptive Epidemiology
Analytic Epidemiology
Interventional Epidemiology
Future Outlook
References
Chapter 6 : Etiological Factors in Skin Cancers: Environmental and Biological
Introduction
History
Risk Factors(Table 6.1)
Future Outlook
References
Chapter 7 : The Importance of Primary and Secondary Prevention Programs for Skin Cancer
Introduction
History
Targeting Prevention Efforts
Primary Prevention Of Skin Cancer: Protection From Ultraviolet Radiation
Secondary Prevention Of Skin Cancer: Early Detection
Future Outlook
Acknowledgement
References
Chapter 8 : Chemoprevention of Skin Cancers
Introduction
History Of Chemoprevention
Principles And Rationale For Chemoprevention Of Non-Melanoma Skin Cancers
Principles And Rationale For Melanoma Chemoprevention
Future Outlook
References
Chapter 9 : Current Concepts in Photoprotection
Introduction
History
Sunscreens
Adjunctive Photoprotection
Future Outlook
References
Chapter 10 : Actinic Keratoses and Other Precursors of Keratinocytic Cutaneous Malignancies
Introduction
Actinic Keratosis (Solar Keratosis)
Other Lesions Associated With Keratinocytic Malignancies
Cutaneous Squamous Cell Carcinoma In Situ And Its Variants
Future Outlook
References
Chapter 11 : Basal cell carcinoma
Introduction
History
Epidemiology
Pathogenesis
Biological Behavior
Clinical Presentation Of Bcc
Histology
Immunohistochemical Features
Treatment
Future Outlook
References
Chapter 12 : Squamous Cell Carcinoma
Introduction And History
Epidemiology
Pathogenesis
Clinical Features
Patient Evaluation, Diagnosis, And Differential Diagnosis
Pathology
Treatment
Prevention
Future Outlook
References
Chapter 13 : Adnexal Carcinomas of the Skin
Introduction
Epidemiology
Carcinomas Of The Eccrine And Apocrine Glands
Carcinomas Of The Hair Follicle
Carcinomas Of The Sebaceous Glands
Future Outlook
References
Chapter 14 : Paget's Disease
Introduction
Mammary Paget'S Disease
Extramammary Paget'S Disease
Future Outlook
Acknowledgement
References
Chapter 15 : Sarcomas of the Skin
Introduction
History
Epidemiology
Pathogenesis And Etiology
General Principles Of Natural History And Diagnosis
Clinicopathologic Features Of Specific Types Of Cutaneous Sarcomas
Other Sarcomas In The Skin
Surveillance
Future Outlook
Acknowledgement
References
Chapter 16 : Kaposi's Sarcoma
Introduction
History
Pathogenesis
Clinical Findings
Clinical Variants
Differential Diagnosis
Evaluation
Treatment
Future Outlook
Acknowledgement
References
Chapter 17 : Merkel Cell Carcinoma
Introduction
History
Epidemiology
Pathogenesis And Etiology
Clinical Features
Patient Evaluation, Diagnosis, And Differential Diagnosis
Pathology
Treatment
Future Outlook
References
Chapter 18 : Malignant Neoplasms: Vascular Differentiation
Introduction
History
Epidemiology
Pathogenesis And Etiology
Low-Grade Angiosarcomas
Intermediate Grade Angiosarcomas (Epithelioid Hemangioendothelioma)
High-Grade Angiosarcomas
Glomangiosarcomas
Future Outlook
References
Chapter 19 : Cutaneous Neoplastic Disorders Related to HPV and HIV Infection
Introduction
Neoplastic Disorders In Hpv-Infected Patients
Vaccination For Hpv
Neoplastic Disorders In Hiv-Infected Patients
Future Outlook
References
Chapter 20 : Pseudolymphomas of the Skin
Introduction
History And Classification
Epidemiology
Patient Evaluation, Diagnosis And Differential Diagnosis
Specific Clinicopathologic Entities
Lymphomatoid drug reactions
Future Outlook
References
Chapter 21 : Cutaneous T-cell Lymphoma: Mycosis Fungoidesand Sézary Syndrome
Introduction
History
Epidemiology
Pathogenesis And Etiology
Clinical Features
Diagnosis, Staging And Pathology
Prognosis
Treatment
Future Outlook
References
Chapter 22 : Dysplastic Nevi
Introduction
History
Epidemiology
Etiology And Pathogenesis: Genes, Environment, And Biology
Clinical Features
Histology
Management
Conclusions
Future Outlook
References
Chapter 23 : Congenital Melanocytic Nevi
Introduction
Epidemiology
Pathogenesis And Etiology
Clinical Features
Pathology
Patient Evaluation, Diagnosis And Differential Diagnosis
Potential Complications
Management
Future Outlook
References
Chapter 24 : The Many Faces of Melanoma
References
Chapter 25 : The Importance of Early Detection of Melanoma,Physician and Self-Examination
Introduction
History Of Melanoma Diagnosis
Clinical Considerations
Patient Evaluation, Diagnosis And Differential Diagnosis
Mass Screenings
Future Outlook
References
Chapter 26 : Prognostic Factors and Staging in Melanoma
Introduction
Ajcc Melanoma Staging System - Overview
Prognostic Factors In Primary Melanoma (Stages I And Ii)
Regional Disease
Distant Metastases
Future Outlook
References
Chapter 27 : Pathology of Melanoma: Interpretation and New Concepts
Introduction
Histologic Diagnosis Of Melanoma
Future Outlook
References
Chapter 28 : Management of the Patient with Melanoma
Introduction
Management
Future Outlook
References
Chapter 29 : Pregnancy and Melanoma
Introduction
History
Epidemiology
Pathogenesis And Etiology
Clinical Features And Prognosis
Patient Evaluation And Diagnosis
Pathology
Treatment
Future Outlook
References
Chapter 30 : Genetic Testing for Melanoma
Introduction
Gene Identification
Genetic Testing In Clinical Practice
Future Outlook
References
Chapter 31 : Spitz Nevus
History
Clinical Features
Pathology
Differentiation From Melanoma
Management Considerations
Future Outlook
References
Chapter 32 : Cutaneous Carcinogenesis Related to Dermatologic Therapy
Introduction
Potential Mechanisms Of Drug-Related Carcinogenesis
Therapies Associated With Increased Skin Cancer Risk
Future Outlook
References
Chapter 33 : Genetic Disorders Predisposing to Skin Malignancy
Basal Cell Nevus Syndrome
Inherited Epidermolysis Bullosa
Xeroderma Pigmentosum
Muir-Torre Syndrome
Epidermodysplasia Verruciformis
Other Genetic Conditions Associated With Skin Cancers
Future Outlook
References
Chapter 34 : Dermatologic Manifestations of Internal Malignancy
Introduction
History
Inherited Syndromes Associated With Internal Malignancy
Skin Changes Resulting from Hormone-Secreting Tumors
Proliferative and Inflammatory Dermatoses Associated with Internal Maligancy (Table 34.2)
Future Outlook
References
Chapter 35 : Dermatologic Manifestations of Systemic Oncologic Therapy of Cutaneous Malignancies
History
Cutaneous Manifestations Of Skin Cancer Systemic Therapy
Chemotherapeutic Agents that Lead to dermatologic Manifestations
Radiation Dermatitis
Future Outlook
References
Chapter 36 : The Dermoscopic Patterns of Melanoma and Non-Melanoma Skin Cancer
Introduction
Dermoscopic Equipment
Basal Cell Carcinoma
Squamous Cell Carcinoma
Melanoma
Future Outlook
References
Chapter 37 : Computer-Aided Diagnosis for Cutaneous Melanoma
Introduction
Computer-Enhanced Total Body Digital Imaging (TBDI)
Dermoscopy
Multispectral Imaging (Multispectral Digital Dermoscopy And Computer-Based Analysis)
Confocal Scanning Laser Microscopy (CLSM) (Reflectance Confocal Microscopy [RCM])
Electrical Impedance Spectroscopy (EIS)
Cellular Electrical Resistance (Bio-Impedance)
Ultrasound Imaging
Magnetic Resonance Imaging (Mri)
Optical Coherence Tomography
Future Outlook
References
Chapter 38 : Confocal Microscopy in Skin Cancer
Introduction
History
Principles Of Reflectance Confocal Microscopy
Normal Skin
Non-Melanoma Skin Cancers
Melanocytic Neoplasms
RCM In Margin Mapping And Monitoring Of Treatment Of Skin Cancer
Future Outlook
References
Chapter 39 : Clinical Genomics for Melanoma Detection
Introduction
Current Melanoma Detection
Epidermal Genetic Information Retrieval (EGIR)
Egir Genomic Characterization Of Melanoma, Nevi, And Normal Skin
Genomic Detection Of Melanoma
Further Development
Future Outlook
Acknowledgements
References
Chapter 40 : Biopsy Techniques
Introduction
Decision-Making Process
Biopsy Techniques - Illustrated
Diagnosis Of Melanoma
Diagnosis Of Non-Melanoma Skin Cancer
Post-Biopsy Care
Summary
Future Outlook
References
Chapter 41 : Curettage and Electrodesiccation
Introduction
History
Description Of Procedure/Therapy
Indications And Contraindications
Future Outlook
References
Chapter 42 : Cryosurgery
Introduction
History
Basic Principles
Equipment
Techniques
Considerations And Applications
Indications And Contraindications
Postoperative Care And Expected Side Effects
Complications (Table 42.5)
Future Outlook
References
Chapter 43 : Topical Treatment of Skin Cancer
Introduction
DNA Analog Antimetabolites
5-fluorouracil
Topical Imidazoquinolones
Cyclooxygenase (COX) Enzyme Inhibitors
Photodynamic Therapy
Retinoids
Bexarotene
Colchicine
Nitrogen Mustard
Emerging Therapies
Head-To-Head Trials Of Topical Chemotherapy
Combination Therapy
Future Outlook
References
Chapter 44 : Immune Response Modulators in the Treatment of Skin Cancer
Introduction
Interferons
Imiquimod
Resiquimod
Interleukin-2 (Il-2)
Other Therapies Which Include Immunomodulative Components
Future Outlook
References
Chapter 45 Photodynamic Therapy in Skin Cancer
Introduction
History
Overview
Topical PDT Therapy
Indications
Adverse Effects
Future Outlook
References
Chapter 46 : Surgical Excision for Non-Melanoma Skin Cancer
Introduction
Perioperative Management
Planning An Excision
Clinical, Surgical, And Histologic Margins
Incomplete Excision And Tumor Recurrence
Future Outlook
References
Chapter 47 : Mohs Surgery
Introduction
Description Of Procedure
General Indications and Contraindications
MMS for Skin Cancer Treatment
Therapuetic Controversies
Safety
Future Outlook
References
Chapter 48 : Treatment of Disseminated Non-Melanoma Skin Cancers
Introduction
Disseminated Basal Cell Carcinoma
Disseminated Squamous Cell Carcinoma
Disseminated Merkel Cell Carcinoma
Adnexal Carcinomas
Future Outlook
References
Chapter 49 : Surgical Excision of Melanoma
Introduction
History
Excision Margin Trials
Current Recommendations
Special Excisional Considerations
Excision Of Histologic Variants
Techniques For Wound Closure Of Resected Melanomas
Mohs Surgery In Melanoma
Future Outlook
References
Chapter 50 : Regional Lymph Node Surgery in Melanoma Patients
Introduction
Approach To Clinically Negative Nodal Basins
Sentinel Lymph Node Biopsy (Sln)
Regional Lymphadenectomy: Indications, Technique And Extent, And Morbidity
Future Outlook
References
Chapter 51 : Reconstructive Surgery for Skin Cancer
Introduction
Planning Reconstructive Surgery For Skin Cancer
Selection Of Reconstructive Techniques
Reconstruction Of The Head And Neck
Reconstruction Of The Trunk
Reconstruction Of The Pelvis/Perineum Area
Reconstruction Of The Upper And Lower Extremities
Future Outlook
References
Chapter 52 : Radiation Therapy in the Treatment of Skin Cancers
Introduction
Principles Of Radiation Therapy
Treatment Of Basal And Squamous Cell Carcinomas
Treatment Of Malignant Melanoma
Treatment Of Kaposi Sarcoma
Treatment Of Cutaneous Lymphomas
Treatment Of Merkel Cell Carcinoma
Future Outlook
References
Chapter 53 : Adjuvant Therapy for Cutaneous Melanoma
Introduction
Prior Approaches
Present Concepts
Indications And Contraindications For IFN
Next Phases Of Development Of Adjuvant Therapies
Future Outlook
References
Chapter 54 : Vaccine Therapy for Melanoma
Introduction
Requirements For An Effective Anti-Melanoma Vaccine
Types Of Vaccines
The Use Of Immunostimulatory Adjuvants
Patient Selection For Vaccine Therapy
Clinical Trials
Could Vaccines Actually Be Harmful?
Current Vaccine Therapy Trials
Future Outlook
References
Chapter 55 : Targeted Therapy for Melanoma
Introduction
Targets In Metastatic Melanoma
Targeting The Melanoma Tumor Microenvironment
Combining Approaches
Future Outlook
References
Chapter 56 : Imaging Work-up of the Patient with Melanoma
Introduction
Imaging At Diagnosis
Ultrasound
Imaging For Surveillance Of Advanced Disease
Management Summary
Future Outlook
References
Chapter 57 : Treatment of Disseminated Melanoma
Introduction
Epidemiology
Staging Of Metastatic Disease
Medical Therapy For Advanced Melanoma
Surgery For Advanced Melanoma
Brain Metastases
Conclusions
Future Outlook
References
Chapter 58 : Management of Skin Cancer in the Immunocompromised Patient
Introduction
Solid Organ Transplant Recipients
Human Immunodeficiency Virus/Acquired Immunodeficiency Disease
Future Outlook
References
Chapter 59 : Indoor Tanning
Introduction
History Of Intentional Tanning
Mechanisms Of Indoor Tanning
Effects Of Indoor Tanning
Indoor Tanning And Skin Cancer
Tanning And Vitamin D
Future Outlook
References
Chapter 60 : Vitamin D and UV: Risks and Benefits
History
Sources And Metabolism Of Vitamin D
Vitamin D In Health And Disease
Optimal Vitamin D Levels
Populations At Risk Of Low Vitamin D Status
Sun Exposure And Vitamin D Levels
Current Vitamin D Recommendations
Future Outlook
References
Chapter 61 : Photography in Skin Cancer Treatment
Introduction
Image Capture Overview
Total Body Photography (TBP)
Close-Up Photography
Image Capture And Management Software
Outside Services
Reimbursement For Services
Future Outlook
References
Chapter 62 : Psychological Responses and Coping Strategies in SkinCancer Patients
Introduction
Psychological Challenges Associated With Early-Stage Skin Cancers
Prevalence Of Psychological Distress In Patients With Skin Cancer
Psychological Distress In Individuals With A Strong Family History Of Skin Cancer
Vulnerability Factors: Demographic, Clinical, And Psychosocial Correlates Of Distress
Coping Skills And Strategies
Psychological Support For Patients With Skin Cancer
Cost-Effectiveness Of Psychosocial Interventions
Communication Skills And Strategies
Current Care And Future Directions
Future Outlook
References
Chapter 63 : Medical and Legal Aspects of Skin Cancer Patients
Introduction
Medical Malpractice
Consent/Refusal For Treatment
Medical Records
Adverse Events And Complications In Skin Cancer Treatment
Special Medicolegal Issues In Skin Cancer Treatment (Dermatopathology)
Future Outlook
References
Index

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Cancer of the Skin E-Book

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