PROCESSING AND APPLICATIONS OF BIODEGRADABLE SYSTEMS Biodegradable Polymers in Medicine M. Suzuki and Y. Ikada Injectable Biodegradable Systems L. F. Boesel and R. L. Reis Injectable Polymeric Scaffolds for Bone Tissue Engineering M.E. Gomes, R.L. Reis, and A.G. Mikos Totally or Partially Biodegradable Self-Polymerizing Composites for Orthopedic Surgery and Dental Applications B. Vazquez, G.A. Abraham, C. Elvira, and J. San Roman Fiber Bonding and Particle Aggregation as Promising Methodologies for the Fabrication of Biodegradable Scaffolds for HardTissue Engineering M.E. Gomes, P.B. Malafaya, and R.L. Reis Design and Fabrication of Scaffolds Via Solid Free Form Fabrication D.W. Hutmacher Biodegradable Composites for Biomedical Applications N. M. Neves, J. F. Mano, and R.L. Reis Development of Bioactive Composites Based on Biodegradable Systems for Bone Replacement Applications B. Leonor, R. A. Sousa, and R.L. Reis Mechanical Characterization of Biomaterials J. F. Mano, N. M. Neves, and R.L. Reis Chitosan-Based Microcomposites - From Biodegradable Microparticles to Self-Curing Hydrogels A. Gallardo, M.R. Aguilar, C. Elvira, C. Peniche, and J. San Roman Processing and Biomedical Applications of Degradable Polymeric Fibers K. Tuzlakoglu and R.L. Reis Understanding the Enzymatic Degradation of Biodegradable Polymers and Strategies to Control Their Degradation Rate H.S. Azevedo and R.L. Reis PRODUCTION OF BIOMIMETIC COATINGS ON THE SURFACE OF DEGRADABLE POLYMERS Bonelike Apatite Coatings Nucleated on Biodegradable Polymers as a Way to Induce Bone Mineralization: Current Developments and Future Trends A. L. Oliveira and R.L. Reis Biomimetic Coatings, Proteins, and Biocatalysts: A New Approach to Tailor the Properties of Biodegradable Polymers I.B. Leonor, H.S. Azevedo, C.M. Alves, and R.L. Reis SYSTEMS FOR CONTROLLED RELEASE OF BIOACTIVE AGENTS Strategies for Delivering Bone and Cartilage Regenerating Factors P.B. Malafaya, G.A. Silva, and R.L. Reis Resorbable Polymeric Delivery Systems Based on Physical Absorption/Diffusion versus Chemically Controlled Delivery Systems J. San Roman, A. Gallardo, C. Elvira, B. Vazquez, and G.A. Abraham Enzyme Immobilization in Biodegradable Polymers for Biomedical Applications S. A. Costa, H.S. Azevedo, and R.L. Reis Use of Chemically Modified Chitosan and Other Natural-Origin Polymers in Tissue Engineering and Drug Delivery E. T. Baran and R.L. Reis BIOCOMPATIBILITY AND IMMUNOLOGICAL RESPONSES TO DEGRADABLE BIOMATERIALS Cytotoxicity Screening of Biodegradable Polymeric Systems G.A. Silva, A. P. Marques, M.E. Gomes, O. P. Coutinho, and R.L. Reis Natural-Origin Degradable Materials: The Barrier or the Passage through the Immune System? P. Marques, J. A. Hunt, and R.L. Reis Mediation of the Cytokine Network in the Implantation of Orthopedic Devices P. Marques, J. A. Hunt, and R.L. Reis Protein and Cell Interactions with Biodegradable Systems C.M. Alves and R.L. Reis Surface Activation and Modification - A Way for Improving the Biocompatibility of Degradable Biomaterials I. Pashkuleva and R.L. Reis BIODEGRADABLE POLYMERS FOR THE ENGINEERING AND REGENERATION OF DIFFERENT TISSUES Bone and Articular Cartilage Tissue Engineering: The Biological Components A.J. Salgado, M.E. Gomes, O. P. Coutinho, and R.L. Reis Tissue Engineering of the Liver Y.M. Elcin Smart Biodegradable Hydrogels with Applications in Drug Delivery and Tissue Engineering C. Elvira, G.A. Abraham, A. Gallardo, and J. San Roman Skin Tissue Engineering Part I - Review D.W. Hutmacher, K. W. Ng, and H. L. Khor Skin Tissue Engineering Part II - The In Vitro Evaluation of Natural and Synthetic 3-D Matrices as Dermal Substrates K. W. Ng, H. L. Khor, and D.W. Hutmacher Biodegradable Polymers for Guided Nerve Regeneration K. Tuzlakoglu and R.L. Reis INDEX