Therapeutics, Evidence and Decision-Making
1st Edition
Published on 29. July 2011
256 pages
978-1-4441-4994-4 (ISBN)
Description
This book is intended to help decision-makers use, assess and appraise the evidence that underpins decisions about the use of therapeutic interventions. It will inform decision-makers about the nature of evidence, the strengths and weaknesses of the available approaches, and how these can be most effectively distilled for the purpose of reaching reliable conclusions. It aims to encourage decision-makers to base their judgements about the use of therapeutic interventions on an informed appraisal of the totality of the evidence base. Is it reliable? Is it generalisable beyond the context of the environment in which the primary research has been conducted? Do the intervention's benefits outweigh its harms? Is it cost effective as well as clinically effective? Is it, indeed, fit-for-purpose? Ultimately, good judgement is at the heart of decision-making in therapeutics.
An invaluable text for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence-based therapeutics.
An invaluable text for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence-based therapeutics.
More details
Edition
1. Auflage
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
ISBN-13
978-1-4441-4994-4 (9781444149944)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Michael Rawlins
Therapeutics, Evidence and Decision-Making
Book
07/2011
1st Edition
Royal Society of Medicine Press Ltd
€78.27
Shipment within 3-4 weeks
Person
"Professor Sir Michael Rawlins MD FRCP(Lond) FRCP(Edin) FFPM FMedSci, National Institute for Clinical Excellence, London, UK
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Content
Introduction: The nature of evidence. Probability. Clinical endpoints of benefits and harms. Statistical expressions of benefit and harm. Bias and confounding. Systematic reviews. Randomized controlled trials: . General principles. Stopping rules. Analysis of subgroups. Safety. Generalizability. Observational studies: General overview. Historical controlled trials. Concurrent cohort studies. Case-control designs. Databases. Case reports. Qualitative research: Approaches and methods. Uses in the evaluation of therapeutic interventions. Economic evaluation: General principles. Cost-effectiveness, cost-utility and cost-minimization analyses. Cost-consequences analysis. Decision-making: . For individuals. For populations.
