Chromatographic Methods and Research
Published on 18. October 2023
195 pages
979-8-89113-203-0 (ISBN)
Description
This book contains six chapters that detail chromatographic methods and research. Chapter One discusses how liquid chromatography-ultraviolet (LC-UV) bioanalytical methods can be considered an important tool for beta-lactams serum measurements to evaluate in a real time drug effectiveness in septic burn patient's bedside. Chapter Two focuses on the preconcentration strategies coupled with chromatographic methods used for the detection of various types of organic compounds. Chapter Three details the bioanalytical methods, based on liquid chromatography, for the therapeutic drug monitoring of combined therapies of antibiotics in pediatric burns. Chapter Four presents liquid chromatography-tandem mass spectrometry. Chapter Five briefs about the determination of an antiviral drug, favipiravir (FVPR) in pure and pharmaceutical dosage forms and different biological matrix of samples, by employing various chromatographic techniques. Lastly, Chapter Six outlines key considerations for the analysis of the hormone a-MSH in brain tissue by the liquid chromatography tandem mass spectrometry (LC-MS/MS) method.
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Raven W. Obrien
Chromatographic Methods and Research
Book
10/2023
Nova Science Publishers Inc
€257.42
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Content
- Intro
- Contents
- Preface
- Chapter 1
- Beta-Lactam Agents Serum Measurements by Liquid Chromatography to Evaluate Meropenem and Piperacillin Effectiveness in Septic Burn Adults with a Pharmacokinetic-Pharmacodynamic Approach
- Abstract
- Abbreviations
- Introduction
- Rational of Study
- Bioanalytical Method for Beta-Lactam Serum Levels
- Meropenem
- Piperacillin
- Clinical Trial: Patient Eligibility, Beta-Lactams Therapy, Blood Sampling, Pharmacokinetics, PK/PD Approach
- Analytical Procedures for Drug Serum Measurements
- Clinical Studies
- Clinical Meropenem Study
- Clinical Piperacillin Study
- Conclusion
- Disclaimer
- References
- Biographical Sketches
- Chapter 2
- Preconcentration Strategies Coupled with Chromatographic Methods for the Determination of Organic Compounds
- Abstract
- Introduction
- Liquid-Liquid Extraction (LLE)
- Solid-Phase Extraction (SPE)
- Applications
- Conclusion
- References
- Chapter 3
- Bioanalytical Methods Based on Liquid Chromatography for the Therapeutic Drug Monitoring of Combined Therapies of Antibiotics in Pediatric Septic Major Burns
- Abstract
- Introduction
- Rational of Study
- Bioanalytical Method
- Clinical Trial: Study Design and Patient Eligibility, Combined Therapy, Blood Sampling, PK/PD Approach
- Analytical Procedures for Drug Serum Measurements
- Clinical Study
- Vancomycin Effectiveness Based on Serum Monitoring
- Meropenem Effectiveness Based on Serum Monitoring
- Conclusion
- Disclaimer
- References
- Biographical Sketch
- Chapter 4
- Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Piperacillin-Meropenem Serum Measurements in Septic Burns for Effectiveness
- Abstract
- Abbreviations
- Introduction
- Rational of Study
- Bioanalytical Method
- Clinical Trial Study: Study Design, Patient Eligibility, Meropenem and Piperacillin Therapy
- Analytical Procedures
- Clinical Study Meropenem and Piperacillin
- Conclusion
- Disclaimer
- References
- Chapter 5
- A Brief Review of Chromatographic Methods for the Quantification of Favipiravir
- Abstract
- Introduction
- The Basic Principles of Chromatography Separation
- Favipiravir
- Mode of Action
- Physiological Properties and Stability of FVPR
- Pharmacology, Pharmacokinetics and Pharmacodynamics of FVPR
- Analysis of FVPR by Various Chromatographic Techniques
- Sample Treatment
- Standard Stock Solution
- Sample Solution- Pharmaceutical Formulation
- Sample Solution-Blood Sample
- High Performance Liquid Chromatography (HPLC)
- High-Performance Liquid Chromatography and Tandem Mass Spectrometry (HPLC-MS/MS)
- Gas Chromatography (GC)
- High Performance Thin Layer Chromatography (HPTLC)
- Conclusion
- Disclaimer
- References
- Biographical Sketch
- Chapter 6
- Advances in Quantitative Liquid Chromatography-Mass Spectroscopy for Central Nervous System Melanocortin Hormone Quantification
- Abstract
- Introduction
- Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method to Measure a-MSH and Its Analogous Compounds in the Brain
- Standard Internal (IS)
- Sample Preparation
- Sample Collection
- Extraction Procedures
- Mass Spectrum Ion Detection
- Discussion
- Conclusion
- Disclaimer
- References
- Index
- Blank Page
