Indicator Displacement Assays (IDAs): An Innovative Molecular Sensing Approach
1st Edition
Published on 7. August 2024
205 pages
978-981-5165-91-3 (ISBN)
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Ishfaq Ahmad Rather | Rashid Ali
Indicator Displacement Assays (IDAs)
An Innovative Molecular Sensing Approach
Book
07/2024
Bentham Science Publishers
€76.81
Shipment within 3-4 weeks
Content
- Cover
- Title
- Copyright
- End User License Agreement
- Contents
- Foreword
- Preface
- Background and Basic Concepts of Indicator Displacement Assays
- 1. INTRODUCTION
- 2. COMMONLY USED SYNTHETIC RECEPTORS AND INDICATORS FOR THE DESIGN OF IDAS
- 3. VARIOUS PHYSICAL AND CHEMICAL PHENOMENA INVOLVED IN CHEMICAL SENSING
- 3.1. Photoinduced Electron Transfer (PET)
- 3.2. Fluorescence Resonance Energy Transfer (FRET)
- 3.3. Charge-Transfer (CT)
- 3.4. Excited-State Intramolecular Proton Transfer (ESIPT)
- 3.5. Photon Upconversion (UC)
- 3.6. Aggregation-Induced Emission (AIE)
- 4. CLASSIFICATION OF CHEMICAL SENSORS
- 4.1. Electrical and Electrochemical Sensors
- 4.2. Thermometric Sensors
- 4.3. Optical Sensors
- 5. USEFULNESS AND APPLICATIONS OF INDICATOR DISPLACE- MENT ASSAYS
- 6. IDA-BASED THERMODYNAMIC EQUILIBRIUM
- 7. ROLE OF INTERMOLECULAR INTERACTIONS IN DESIGNING IDAS
- 7.1. Hydrogen Bonding (H-bonding)
- 7.2. Halogen Bonding
- 7.3. Cation-p and Anion-p Interactions
- 7.4. CH-p and p -p Stacking Interactions
- 7.5. Van Der Waals Interactions
- 8. DESIGN STRATEGIES OF IDAS
- 9. SUPRAMOLECULAR TANDEM ASSAYS
- 10. ADVANTAGES AND DISADVANTAGES OF IDA-BASED SENSORS
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- Colorimetric Indicator Displacement Assays (C-IDAs)
- 1. INTRODUCTION
- 2. CHROMOGENIC SENSING ENSEMBLE
- 2.1. Thermodynamic Equilibrium
- 2.2. Molecular Design Setup and Environmental Factors
- 2.3. Signal Transduction Mechanism
- 3. CLASSIFICATION OF SENSING ENSEMBLES
- 3.1. Two-Component Sensing Ensembles
- 3.2. Three-Component Sensing Ensembles
- 3.3. Multicomponent Sensing Ensembles
- 3.4. Inorganic-Organic Hybrid Sensing Ensembles
- 4. C-IDA BASED ANION SENSORS
- 4.1. Phosphate Anion Sensors
- 5. C-IDA BASED CATION SENSORS
- 6. C-IDA BASED SACCHARIDE SENSORS
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- Fluorescence Indicator Displacement Assays (F-IDAs)
- 1. INTRODUCTION
- 2. F-IDA BASED ANION SENSORS
- 2.1. Phosphate Anion F-IDA Sensors
- 2.2. Sensors for Fluoride, Bicarbonate and Citrate Ions
- 3. SENSORS FOR SACCHARIDES
- 4. SENSORS FOR BIOMARKERS
- 5. SENSORS FOR PHARMACOLOGICAL DRUGS
- 6. SENSORS FOR NEUROTRANSMITTERS
- 7. SENSORS FOR EXPLOSIVES AND TOXIC SUBSTANCES
- 8. SENSORS FOR PEPTIDES AND METABOLIC WASTE PRODUCTS
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- Metal Complexing Indicator Displacement Assays (M-IDAs)
- 1. INTRODUCTION
- 2. M-IDA BASED SENSORS FOR PHOSPHATE AND OTHER VITAL ANIONS
- 3. SENSORS FOR THE SACCHARIDES, WARFARE AGENTS AND BIOMARKERS
- 4. SENSORS FOR AMINO ACIDS, NEUROTRANSMITTERS, SULFIDES, AND T-DNA
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- Recent Extensions of IDA-based Sensing Protocols
- 1. INTRODUCTION
- 2. ENANTIOSELECTIVE INDICATOR DISPLACEMENT ASSAYS (E-IDAS)
- 3. INDICATOR CATALYST DISPLACEMENT ASSAY (ICDA)
- 4. INTRAMOLECULAR INDICATOR DISPLACEMENT ASSAYS (I-IDAS)
- 5. REACTION BASED INDICATOR DISPLACEMENT ASSAYS (R-IDAS)
- 6. ALLOSTERIC INDICATOR DISPLACEMENT ASSAY (A-IDA)
- 7. MECHANICALLY CONTROLLED INDICATOR DISPLACEMENT ASSAYS (MC-IDAS)
- 8. DIMER DYE ASSEMBLY ASSAY (DDA)
- 9. QUENCHER DISPLACEMENT ASSAY (QDA)
- 10. CATALYTIC CHEMOSENSING ASSAY (CCA)
- CONCLUSION AND OUTLOOK
- ACKNOWLEDGEMENTS
- REFERENCES
- IDA-based Differential Sensory Arrays and Assays
- 1. INTRODUCTION
- 2. IDA OPERATED SINGLE ANALYTE SENSING VERSES DIFFERENTIAL SENSING
- 3. SENSORY ARRAY EXPERIMENTAL DATA ANALYSIS
- 4. DIFFERENTIAL SENSING OF ATP AND GLYCOSAMINOGLYCANS
- 5. DIFFERENTIAL SENSING OF PROTEINS, AMINO ACIDS AND GLYCOPROTEINS
- 6. DIFFERENTIAL SENSING OF ORGANOPHOSPHATES AND OTHER VITAL ANIONS
- 7. DIFFERENTIAL SENSING OF SACCHARIDES AND METABOLITES
- 8. DIFFERENTIAL SENSING OF POLYPHENOLS AND GINSENOSIDES
- 9. IDA-BASED MOLECULARLY IMPRINTED POLYMERIC SENSORY ARRAYS
- CONCLUSION AND OUTLOOK
- REFERENCES
- Electrochemical Sensors Based on Indicator Displacement Assays
- 1. INTRODUCTION
- 2. TYPES OF ELECTROCHEMICAL SENSORS
- 2.1. Potentiometric Sensors
- 2.1.1. Ion-Selective Electrodes (ISEs)
- 2.1.2. Coated Wire Electrodes (CWEs)
- 2.1.3. Ion Selective Field Effect Transistors (ISFET)
- 2.2. Amperometric Sensors
- 2.3. Conductometric Sensors
- 3. TECHNIQUES USED IN ELECTROCHEMICAL SENSING
- 3.1. Voltammetry
- 3.1.1. Sweep Type Methods
- 3.1.2. Polarographic Techniques
- 3.2. Amperometry
- 3.3. Electrochemical Impedance Spectroscopy
- 4. IDA BASED ELECTROCHEMICAL SENSORS FOR SACCHARIDES
- 5. IDA-BASED ELECTROCHEMICAL SENSORS FOR BIOMARKERS
- 6. MISCELLANEOUS EXAMPLES
- CONCLUSION
- ACKNOWLEDGEMENTS
- REFERENCES
- LIST OF ABBREVIATIONS
- LIST OF ABBREVIATIONS
- Subject Index
- Back Cover
