Kratom and Other Mitragynines
The Chemistry and Pharmacology of Opioids from a Non-Opium Source
Published on 29. October 2014
366 pages
978-1-040-17701-3 (ISBN)
Description
Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature's only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds-those derived from the plant Mitragyna speciosa. This plan
Reviews / Votes
"This is a novel foray into the realm of reviews on non-poppy-derived opioids and their pharmacology and ... provides very solid information about the chemistry of the mitragynines...The editor, Robert Raffa, is a widely known expert in the pharmacology of opioid drugs with significant knowledge and respect in the field."-Kenneth E. McCarson, BChE, PhD, University of Kansas Medical Center for Doody's Review Service
"This book should be an indispensable single-volume information source for anyone working in the fields of opioid chemistry, pharmacology and toxicology. Some chapters would be of particular interest to ... specialists working in addiction treatment and drug regulation. The book would also be an excellent addition to any library collection specialized in natural products or drugs of abuse."
-Journal of Addition Research and Therapy "This is a novel foray into the realm of reviews on non-poppy-derived opioids and their pharmacology and ... provides very solid information about the chemistry of the mitragynines...The editor, Robert Raffa, is a widely known expert in the pharmacology of opioid drugs with significant knowledge and respect in the field."
-Kenneth E. McCarson, BChE, PhD, University of Kansas Medical Center for Doody's Review Service
"This book should be an indispensable single-volume information source for anyone working in the fields of opioid chemistry, pharmacology and toxicology. Some chapters would be of particular interest to ... specialists working in addiction treatment and drug regulation. The book would also be an excellent addition to any library collection specialized in natural products or drugs of abuse."
-Journal of Addition Research and Therapy
More details
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
File size
3,41 MB
ISBN-13
978-1-040-17701-3 (9781040177013)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Robert B. Raffa
Kratom and Other Mitragynines
The Chemistry and Pharmacology of Opioids from a Non-Opium Source
Book
12/2019
1st Edition
CRC Press
€84.40
Shipment within 15-20 days
Robert B. Raffa
Kratom and Other Mitragynines
The Chemistry and Pharmacology of Opioids from a Non-Opium Source
Book
10/2014
1st Edition
CRC Press
€263.00
Article not available for order
Person
Robert B. Raffa is a professor of pharmacology in the Department of Pharmaceutical Sciences at Temple University School of Pharmacy as well as a research professor in the Department of Pharmacology at Temple University School of Medicine. He has bachelor's degrees in chemical engineering and in physiological psychology, master's degrees in biomedical engineering and toxicology, and a doctorate in pharmacology. Dr. Raffa was co-leader for analgesics discovery at Johnson & Johnson and was pivotal in the elucidation of the mechanism of action and development of the analgesic drug tramadol (Ultram ). He is the co-holder of several patents, including the combination of tramadol plus acetaminophen (Ultracet ). He has published more than 280 scientific articles in peer-reviewd journals and is the co-author or editor of several books.
Content
Why Do Plants Contain Biologically Active Compounds? Short Overview of Mitragynines. Psychopharmacological Indole Alkaloids from Terrestrial Plants. Salvinorin A: Example of a Non-Alkaloidal Bioactive Opioid from a Plant Source. Mitragyna speciosa (Korth.) Havil. Phytochemistry of Mitragyna speciosa. Chemistry of Mitragynines: A Brief Introduction . Chemistry of Mitragyna Compounds. Medicinal Chemistry Based on Mitragynine. Chemical Structures of Opioids. The Detection of Mitragynine and Its Analogs. The ADME of Mitragynine and Analogs. Analgesic Effects of Mitragynine and Analogs. Non-Analgesic CNS Effects. Other Opioid-Associated Endpoints. The Kratom Experience From Firsthand Reports. The Toxicology of Indole Alkaloids. Opioid-Induced Adverse Effects and Toxicity. Toxicology of Mitragynine and Analogs. The Use of Animal Models to Measure Tolerance, Dependence, and Abuse Potential. Kratom: The Epidemiology, Use and Abuse, Addiction Potential, and Legal Status.
