Lecture Notes Clinical Biochemistry
10th Edition
Published on 13. July 2017
328 pages
978-1-119-24863-7 (ISBN)
Description
Clinical Biochemistry Lecture Notes presents the fundamental science behind common biochemical investigations used in clinical practice. Taking a system-based approach, it explores the underlying physiological rationale for tests, with each test explained within the context of disruption by disease. It also explores the value and limitations of biochemical investigations, while helping readers to quickly develop the knowledge and skills required to select the appropriate investigations for diagnosis and management, and to correctly interpret test results. Case studies throughout chapters place the information within a clinical context to further assist readers in the development of test-selection and interpretation skills.
Key features include:
* A comprehensive, yet concise overview of the science behind common biochemical investigations
* Helps readers rapidly acquire a fully integrated, practical understanding of biochemical diagnostics
* Full-colour flowcharts and algorithms detailing the rationale for tests, the biochemical processes involved, and test procedures, for quick comprehension and reference
* More clinical cases demonstrating application to practice
Now in its tenth edition, this classic introductory, reference, and revision text is indispensable to medical students, and all those who want to quickly acquire a practical understanding of the scientific principles underpinning biochemical tests and a working knowledge of test selection, test procedures, and the interpretation of results within a clinical context.
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Other editions
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Peter Rae | Mike Crane | Rebecca Pattenden
Clinical Biochemistry
Book
10/2017
Wiley-Blackwell
€49.46
Shipment within 15-20 days
Persons
Peter Rae is Consultant Clinical Biochemist at the Royal Infirmary of Edinburgh, and Honorary Senior Lecturer, University of Edinburgh, UK.
Mike Crane is Consultant Clinical Scientist at the Royal Infirmary of Edinburgh and Royal Hospital for Sick Children, and Honorary Lecturer, University of Edinburgh, UK.
Rebecca Pattenden is Consultant Clinical Scientist at Western General Hospital, Edinburgh, UK.
Content
Preface, vi
List of abbreviations, vii
About the companion website, x
1 Requesting and interpreting tests, 1
2 Disturbances of water, sodium and potassium balance, 12
3 Acid-base balance and oxygen transport, 30
4 Renal disease, 43
5 Disorders of calcium, phosphate and magnesium metabolism, 60
6 Diabetes mellitus and hypoglycaemia, 77
7 Disorders of the hypothalamus and pituitary, 91
8 Abnormalities of thyroid function, 105
9 Disorders of the adrenal cortex and medulla, 121
10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism, 139
11 Pregnancy and antenatal screening, 158
12 Cardiovascular disorders, 167
13 Liver disease, 183
14 Gastrointestinal tract disease, 198
15 Nutrition, 208
16 Inflammation, immunity and paraproteinaemia, 224
17 Malignancy and tumour markers, 234
18 Disorders of iron and porphyrin metabolism, 241
19 Uric acid, gout and purine metabolism, 252
20 Central nervous system and cerebrospinal fluid, 259
21 Therapeutic drug monitoring and chemical toxicology, 263
22 Clinical biochemistry in paediatrics and the elderly, 276
Index, 29
List of abbreviations
- a-MSH
- a-melanocyte stimulating hormone
- AAT
- a1-antitrypsin
- ABP
- androgen-binding protein
- A&E
- accident and emergency
- ACE
- angiotensin-converting enzyme
- ACTH
- adrenocorticotrophic hormone
- ADH
- antidiuretic hormone
- AFP
- a-foetoprotein
- AI
- angiotensin I
- AII
- angiotensin II
- AIII
- angiotensin III
- AIP
- acute intermittent porphyria
- AIS
- androgen insensitivity syndrome
- ALA
- aminolaevulinic acid
- ALP
- alkaline phosphatase
- ALT
- alanine aminotransferase
- AMA
- anti-mitochondrial antibodies
- AMH
- anti-Mullerian hormone
- AMP
- adenosine 5-monophosphate
- ANP
- atrial natriuretic peptide
- AST
- aspartate aminotransferase
- ATP
- adenosine triphosphate
- AT
- Pase adenosine triphosphatase
- ß-LPH
- ß-lipotrophin
- BChE
- butylcholinesterase
- BMI
- body mass index
- BMR
- basal metabolic rate
- BNP
- B-type natriuretic peptide
- CABG
- coronary artery bypass grafting
- CAH
- congenital adrenal hyperplasia
- cAMP
- cyclic adenosine monophosphate
- CBG
- cortisol-binding globulin
- CCK
- cholecystokinin
- CCK-PZ
- cholecystokinin-pancreozymin
- CDT
- carbohydrate-deficient transferrin
- CEA
- carcinoembryonic antigen
- CFT
- calculated free testosterone
- ChE
- cholinesterase
- CK
- creatine kinase
- CKD
- chronic kidney disease
- CNS
- central nervous system
- CoA
- coenzyme A
- COC
- combined oral contraceptive
- COHb
- carboxyhaemoglobin
- CRH
- corticotrophin-releasing hormone
- CRP
- C-reactive protein
- CSF
- cerebrospinal fl uid
- CT
- computed tomography
- CV
- coefficient of variation
- DDAVP
- 1-deamino,8-D-arginine vasopressin
- DHEA
- dehydroepiandrosterone
- DHEAS
- dehydroepiandrosterone sulphate
- DHCC
- dihydrocholecalciferol
- DHT
- dihydrotestosterone
- DIT
- di-iodotyrosine
- DKA
- diabetic ketoacidosis
- DPP
- 4 dipeptidyl peptidase-4
- DSD
- disorder of sexual differentiation
- DVT
- deep venous thrombosis
- ECF
- extracellular fluid
- ECG
- electrocardiogram/electrocardiography
- ED
- erectile dysfunction
- EDTA
- ethylenediamine tetraacetic acid
- eGFR
- estimated glomerular filtration rate
- EPH
- electrophoresis
- EPP
- erythropoietic protoporphyria
- ERCP
- endoscopic retrograde cholangiopancreatography
- ESR
- erythrocyte sedimentation rate
- FAD
- flavin adenine dinucleotide
- FAI
- free androgen index
- FBHH
- familial benign hypocalciuric hypercalcaemia
- FIT
- faecal immunochemical test
- FMN
- flavin mononucleotide
- FOB
- faecal occult blood
- FPP
- free protoporphyrin
- FSH
- follicle-stimulating hormone
- FT3
- free tri-iodothyronine
- FT4
- free thyroxine
- GAD
- glutamic acid decarboxylase
- Gal-1-PUT
- galactose-1-phosphate uridylyl-transferase
- GDM
- gestational diabetes mellitus
- GFR
- glomerular filtration rate
- GGT
- ?-glutamyltransferase
- GH
- growth hormone
- GHD
- growth hormone deficiency
- GHRH
- growth hormone-releasing hormone
- GI
- gastrointestinal
- GIP
- glucose-dependent insulinotrophic peptide/gastric inhibitory polypeptide
- GLP-1
- glucagon-like polypeptide-1
- GnRH
- gonadotrophin-releasing hormone
- GP
- general practitioner
- GSH
- glucocorticoid-suppressible hyperaldosteronism
- GTT
- glucose tolerance test
- Hb
- haemoglobin
- HC
- hereditary coproporphyria
- HCC
- hydroxycholecalciferol
- hCG
- human chorionic gonadotrophin
- HDL
- high-density lipoprotein
- HGPRT
- hypoxanthine-guanine phosphoribosyltransferase
- HHS
- hyperosmolar hyperglycaemic state
- 5-HIAA
- 5-hydroxyindoleacetic acid
- HIV
- human immunodeficiency virus
- HLA
- human leucocyte antigen
- HMG-CoA
- ß-hydroxy-ß-methylglutaryl-coenzyme A
- HMMA
- 4-hydroxy-3-methoxymandelic acid
- HNF
- hepatic nuclear factor
- HPA
- hypothalamic-pituitary-adrenal
- HPLC
- high-performance liquid chromatography
- HRT
- hormone replacement therapy
- hsCRP
- highly sensitive C-reactive protein
- 5-HT
- 5-hydroxytryptamine
- 5-HTP
- 5-hydroxytryptophan
- IBS
- irritable bowel syndrome
- ICF
- intracellular fluid
- ICU
- intensive care unit
- IDL
- intermediate-density lipoprotein
- IFCC
- International Federation for Clinical Chemistry
- IFG
- impaired fasting glucose
- Ig
- immunoglobulin
- IGF
- insulin-like growth factor
- IGFBP
- insulin-like growth factor-binding protein
- IGT
- impaired glucose tolerance
- IM
- intramuscular
- INR
- international normalised ratio
- IV
- intravenous
- LCAT
- lecithin cholesterol acyltransferase
- LDH
- lactate dehydrogenase
- LDL
- low-density lipoprotein
- LH
- luteinising hormone
- Lp(a)
- lipoprotein (a)
- LSD
- lysergic acid diethylamide
- MCAD
- medium chain acyl-CoA dehydrogenase
- MCV
- mean cell volume
- MDRD
- Modification of Diet in Renal Disease
- MEGX
- monoethylglycinexylidide
- MEN
- multiple endocrine neoplasia
- MGUS
- monoclonal gammopathy of unknown significance
- MI
- myocardial infarction
- MIT
- mono-iodotyrosine
- MODY
- maturity onset diabetes of the young
- MOM
- multiples of the median
- MRCP
- magnetic resonance cholangiopancreatography
- MRI
- magnetic resonance imaging
- MTC
- medullary thyroid cancer
- MUST
- Malnutrition Universal Screening Tool
- NABQI
- N-acetyl-p-benzoquinoneimine
- NAC
- N-acetylcysteine
- NAD
- nicotinamide-adenine dinucleotide
- NADP
- NAD phosphate
- NAFLD
- nonalcoholic fatty liver disase
- NASH
- nonalcoholic steatohepatitis
- NICE
- National Institute for Health and Clinical Excellence
- NIPT
- noninvasive prenatal testing
- NSAID
- nonsteroidal anti-inflammatory agent
- NTD
- neural tube defect
- NTI
- nonthyroidal illness
- OCP
- oral contraceptive pill
- OGTT
- oral glucose tolerance test
- PAPP-A
- pregnancy-associated plasma protein A
- PBG
- porphobilinogen
- PCI
- percutaneous coronary intervention
- PCOS
- polycystic ovarian syndrome
- PCSK9
- proprotein convertase subtilisin/kexin type 9
- PCT
- porphyria cutanea tarda
- PE
- pulmonary embolism
- PEG
- percutaneous endoscopic gastrostomy
- PEM
- protein-energy malnutrition
- PIIINP
- pro-collagen type III
- PKU
- phenylketonuria
- PLP
- pyridoxal 5´-phosphate
- POCT
- point of care testing
- POP
- progestogen-only pill
- PRPP
- 5-phosphoribosyl-1-pyrophosphate
- PSA
- prostate-specific antigen
- PT
- prothrombin time
- PTH
- parathyroid hormone
- PTHrP
- PTH-related protein
- RBP
- retinol-binding protein
- RDA
- recommended dietary allowance
- RF
- rheumatoid factor
- RMI
- risk of malignancy index
- ROC
- receiver operating characteristic
- SAAG
- serum-ascites albumin gradient
- SAH
- subarachnoid haemorrhage
- SD
- standard deviation
- SHBG
- sex hormone-binding globulin
- SIADH
- inappropriate secretion of ADH
- SGLT
- sodium-glucose cotransporter
- SUR
- sulphonylurea receptor
- T3
- tri-iodothyronine
- T4
- thyroxine
- TBG
- thyroxine-binding globulin
- TDM
- therapeutic drug monitoring
- TDP
- thiamin diphosphate
- TGN
- 6-thioguanine nucleotide
- THR
- thyroid hormone resistance
- TIBC
- total iron-binding capacity
- TNF
- tumour necrosis...
