
Protocols for High-Risk Pregnancies
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As with the prior six editions, the editors have once again assembled some of the world's top obstetrical and medical experts. This seventh edition has also been expanded to include a number of new topics, including:
* Protocols on opioid use, misuse and addition in pregnancy and postpartum
* Noninvasive prenatal diagnosis of aneuploidy
* Periconceptual genetic screening
* Expanded protocols on maternal valvular heart disease and cardiomyopathies
* Protocols on arboviruses, including Zika and malaria
Protocols for High-Risk Pregnancies: An Evidence-Based Approach will be an essential reference for obstetricians, medical students, general practitioners and all medical professionals who are seeking the most up-to-date information and guidance on high-risk pregnancies.
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Persons
About the Editors
JOHN T. QUEENAN, MD, Professor and Chairman Emeritus, Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA.
CATHERINE Y. SPONG, MD, is a Professor and Vice Chair in the Department of Obstetrics and Gynecology at University of Texas Southwestern Medical Center, Dallas, TX, USA. She also serves as Chief of the Department's Division of Maternal-Fetal Medicine.
CHARLES J. LOCKWOOD, MD, MHCM, is Senior Vice President of USF Health, Dean of Morsani College of Medicine and a Professor of Obstetrics and Gynecology, and Public Health at the University of South Florida in Tampa, FL, USA.
Content
Preface ix
List of Contributors xi
Part 1 Concerns in Pregnancy
1 Alcohol Use in Pregnancy and Lactation 3
Ruta M. Nonacs
2 Smoking, Vaping, and Nicotine Exposure 9
John Byrne and George Saade
3 Opioid Use, Misuse, and Addiction in Pregnancy and Postpartum 15
Mishka Terplan
4 Depression 21
Kimberly Yonkers
Part 2 Antenatal Testing
5 Prenatal Testing for Chromosomal Abnormalities 29
Mary E. Norton
6 Fetal Echocardiography 41
Joshua A. Copel
7 Clinical Use of Doppler 49
Henry L. Galan
8 Antepartum Testing 61
Michael P. Nageotte
9 Fetal Blood Sampling and Transfusion 69
Patricia Santiago-Munoz
10 Preconception Genetic Screening 77
Lauren Sayres and Jeffrey A. Kuller
Part 3 Maternal Disease
11 Maternal Anemia 89
Elaine Duryea
12 Hemoglobinopathies in Pregnancy 97
Bradley Sipe and Judette Louis
13 Fetal and Neonatal Alloimmune Thrombocytopenia 105
Russell Miller and Richard Berkowitz
14 Rheumatological Disorders 113
Lisa R. Sammaritano and Bonnie L. Bermas
15 Antiphospholipid Syndrome 125
Robert M. Silver
16 Inherited Thrombophilias 131
Andra H. James and Jerome J. Federspiel
17 Valvular Heart Disease in Pregnancy 141
Blake Zwerling and Afshan B. Hameed
18 Peripartum Cardiomyopathy 165
Sarah Rae Easter and Carolyn M. Zelop
19 Thromboembolism 181
Michael J. Paidas
20 Renal Disease 201
Shivani Patel
21 Obesity 209
Patrick S. Ramsey
22 Diabetes Mellitus 219
Mark B. Landon and Steven G. Gabbe
23 Thyroid Disorders 231
Elizabeth O. Buschur and Stephen F. Thung
24 Hepatitis in Pregnancy 241
Andrew Myers, Asa Oxner, John Sinnott, and Christian Brechot
25 Asthma 253
Michael Schatz
26 Epilepsy 263
Thomas McElrath
27 Chronic Hypertension 273
Michal Fishel Bartal and Baha M. Sibai
28 Cytomegalovirus, Genital Herpes, Rubella, and Toxoplasmosis 285
Kerry E. Drury and Brenna L. Hughes
29 Syphilis 293
Emily H. Adhikari
30 Vector-Borne Diseases in Pregnancy: Zika, West Nile, and Chagas Disease 301
Karin Nielsen-Saines and Tara Kerin
31 Influenza 317
Amanda C. Zofkie and Vanessa Rogers
32 Malaria 323
Blair J. Wylie
33 Human Immunodeficiency Virus Infection 333
Emily H. Adhikari
34 Parvovirus B19 343
Kathy C. Matthews, Emilie L. Vander Haar, and Laura E. Riley
35 Group B Streptococcus 351
Caitlin A. MacGregor, and Mara J. Dinsmoor
36 Biliary, Liver, and Pancreatic Disease 361
Vic Velanovich, Elizabeth Hoover, and Stephanie Ros
Part 4 Obstetric Problems
37 Cervical Insufficiency 375
Rupsa C. Boelig and Vincenzo Berghella
38 Nausea and Vomiting 387
Jared T. Roeckner and Haywood L. Brown
39 Fetal Death and Stillbirth 397
Alexander M. Saucedo and Robert M. Silver
40 Abnormal Amniotic Fluid Volume 407
Christina M. Ackerman, Thomas R. Moore, and Heather S. Lipkind
41 Fetal Growth Restriction 421
Jodi S. Dashe and Anne M. Ambia
42 Rh and Other Blood Group Alloimmunizations 431
Kenneth J. Moise Jr
43 Preterm Labor 443
Hyagriv N. Simhan
44 Prevention of Preterm Birth 449
Anna King and Sarah J.E. Stock
45 Premature Rupture of the Membranes 461
Brian M. Mercer
46 Indicated Late-Preterm and Early-Term Deliveries 475
Catherine Y. Spong
47 Chorioamnionitis 481
Catalin S. Buhimschi and Irina A. Buhimschi
48 Third-Trimester Bleeding 493
Ilina D. Pluym and Christina S. Han
49 Amniotic Fluid Embolism 507
Irene A. Stafford and Michael A. Belfort
50 Preeclampsia 517
Michal Fishel Bartal and Baha M. Sibai
Part 5 Labor and Delivery
51 Elective Induction of Labor 531
Rachel G. Sinkey
52 Electronic Fetal Heart Rate Monitoring 539
David A. Miller
53 Breech Delivery 555
G. Justus Hofmeyr, and Mercy-Nkuba Nassali
54 Vaginal Birth After Cesarean 563
James R. Scott
55 Placenta Accreta Spectrum 571
Robert M. Silver and Deirdre J. Lyell
56 Shoulder Dystocia 581
George A. Macones and Robert B. Gherman
57 Twins, Triplets, and Beyond 587
Mary E. D'Alton
58 Postpartum Hemorrhage 601
David B. Nelson
Appendix A: Evaluation of Fetal Health and Defects 613
Lynn L. Simpson
Index 629
List of Contributors
Christina M. Ackerman
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale School of Medicine, New Haven, CT, USA
Emily H. Adhikari
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Anne M. Ambía
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Michal Fishel Bartal
Department of Obstetrics and Gynecology and Reproductive Sciences, The University of Texas Medical School at Houston, Houston, TX, USA
Michael A. Belfort
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
Vincenzo Berghella
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
Richard Berkowitz
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, USA
Bonnie L. Bermas
Division of Rheumatic Diseases, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Rupsa C. Boelig
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
Christian Brechot
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Haywood L. Brown
Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA
Catalin S. Buhimschi
Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IL, USA
Irina A. Buhimschi
Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IL, USA
Elizabeth O. Buschur
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, The Ohio State University Wexner Medical Center, Columbus, OH, USA
John Byrne
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Joshua A. Copel
Departments of Obstetrics, Gynecology and Reproductive Sciences, and Pediatrics, Yale School of Medicine, New Haven, CT, USA
Mary E. D'Alton
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, USA
Jodi S. Dashe
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Mara J. Dinsmoor
Department of Obstetrics and Gynecology, NorthShore University Health System, Evanston, IL, USA
Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Kerry E. Drury
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
Elaine Duryea
Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Sarah Rae Easter
Departments of Obstetrics and Gynecology, and Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Jerome J. Federspiel
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University Medical Center, Durham, NC, USA
Steven G. Gabbe
Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
Henry L. Galan
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Colorado School of Medicine, Colorado Fetal Care Center, Aurora, CO, USA
Robert B. Gherman
Division of Maternal Fetal Medicine, WellSpan Health System, York, PA, USA
Afshan B. Hameed
Division of Obstetrics and Gynecology, Irvine School of Medicine, University of California, Irvine, CA, USA
Christina S. Han
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Center for Fetal Medicine and Women's Ultrasound, Los Angeles, CA, USA
G. Justus Hofmeyr
Effective Care Research Unit, Universities of the Witwatersrand and Fort Hare, Bhisho, South Africa
Department of Obstetrics and Gynecology, University of Botswana, Gaborone, Botswana
Elizabeth Hoover
Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Brenna L. Hughes
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
Andra H. James
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University Medical Center, Durham, NC, USA
Tara Kerin
Department of Pediatrics, David Geffen School of Medicine at UCLA/UCLA Mattel Children's Hospital, Los Angeles, CA, USA
Anna King
Department of Obstetrics and Gynaecology, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
Jeffrey A. Kuller
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University School of Medicine, Durham, NC, USA
Mark B. Landon
Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
Heather S. Lipkind
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale School of Medicine, New Haven, CT, USA
Judette Louis
Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Deirdre J. Lyell
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford University Medical Center, Stanford, CA, USA
Caitlin A. MacGregor
Department of Obstetrics and Gynecology, NorthShore University Health System, Evanston, IL, USA
Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
George A. Macones
Division of Maternal Fetal Medicine, Dell Medical School-University of Texas at Austin, Austin, TX, USA
Kathy C. Matthews
New York Presbyterian-Weill Cornell Medicine, New York, USA
Thomas McElrath
Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Brian M. Mercer
Department of Obstetrics and Gynecology, Case Western University-MetroHealth Medical Center, Cleveland, OH, USA
David A. Miller
Department of Obstetrics, Gynecology and Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA, USA
Russell Miller
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, USA
Kenneth J. Moise Jr
Departments of Obstetrics, Gynecology and Reproductive Sciences, and Pediatric Surgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
Thomas R. Moore
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Perinatal Medicine, University of California San Diego, San Diego, CA, USA
Andrew Myers
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Michael P. Nageotte
Miller Children's and Women's Hospital, Long Beach, CA, USA
Department of Obstetrics and Gynecology, University of California, Irvine, CA, USA
Mercy-Nkuba Nassali
Department of Obstetrics and Gynecology, University of Botswana, Gaborone, Botswana
David B. Nelson
Department of Maternal-Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Karin Nielsen-Saines
Department of Pediatrics, David Geffen School of Medicine at UCLA/UCLA Mattel Children's Hospital, Los Angeles, CA, USA
Ruta M. Nonacs
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Mary E. Norton
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA
Asa Oxner
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Michael J. Paidas
Department of Obstetrics, Gynecology and Reproductive Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA
Shivani Patel
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Ilina D. Pluym
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Patrick S. Ramsey
Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health...
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