Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 25. March 1993
231 pages
978-0-08-086332-0 (ISBN)
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Progress in Nucleic Acid Research and Molecular Biology
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03/1993
Academic Press
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Content
- Cover
- Contents
- Abbreviations and Symbols
- Some Articles Planned for Future Volumes
- Chapter 1. Structure and Action of Mammalian Ribonuclease (Angiogenin) Inhibitor
- I. Purification, Physicochemical Properties, and Occurrence
- II. Primary Structure
- III. Inhibitory Properties
- IV. Biologic Role
- V. Concluding Remarks
- References
- Chapter 2. Bacterial Adenylyl Cyclases
- I. The Action of cAMP as a Transcription Regulator in Escherichia coli
- II. Regulation of cAMP Levels in E. coli
- III. Structure and Expression of the E. coli Adenylyl Cyclase (cya) Gene
- IV. The Phosphoenolpyruvate: Sugar Phosphotransferase System
- V. Regulation of E. coli Adenlyl Cyclase Activity by the Phosphoenolpyruvate:sugar Phosphotransferase System
- VI. Regulation of E. coli Aden lyl Cyclase Activity by Other Factors
- VII. Adenylyl Cyclases in Bacteria Other Than E. coli
- VIII. Sequence Comparisons
- IX. ATP-Binding Sites
- X. Conclusions
- References
- Chapter 3. Itiation of Transcription by RNA Polymerase II: A Multi-step Process
- I. The Structure of Class II Promoters
- II. RNA Polymerase II
- III. Transcription Factors and Systems
- IV. Preinitiation and Initiation Complexes and Motifs
- V. Activation and the General Transcription Factors
- VI. Repression of Class II Gene Transcription
- References
- Chapter 4. Regulation of Repair of Alkylation Damage in Mammalian Genomes
- I. Historical Perspective
- II. Unusual Repair of O6-Alkylguanine
- III. Multistep Repair of N-Alkylpurines
- IV. Properties of Mammalian O6-Methylguanine-DNA Methyltransferases
- V. Cloning of Mammalian Alkylation Repair Genes by Phenotypic Rescue of E. coli
- VI. Regulation of Mammalian MGMT and MPG
- VII. Role of DNA Meth lation in Methyltransferase Gene Regulation
- VIII. Inducibility of Alkylation Repair Genes
- IX. Alkylating Drug Resistance and Regulation of DNA Repair
- X. Amplification of the Methyltransferase Gene and Drug Resistance
- XI. Outlook
- References
- Chapter 5. Cell Delivery and Mechanisms of Action of Antisense Oligonucleotides
- I. Historical Background
- II. From the Antisense to the SNAIGE Concept
- III. Limitations of the SNAIGE Approach
- IV. Internalization and Targeting of Oligonucleotides
- V. lntracellular Distribution of Oligonucleotides
- VI. Mechanisms of Action of Antisense Oligonucleotides in the VSV Model
- VII. Conclusion and Perspectives
- References
- Chapter 6. Enzyme Organization in DNA Precursor Biosynthesis
- I. Enzyme Organization and Contemporary Enzymology
- II. Early Evidence for dNTP Compartmentation
- III. T4 dNTP Synthetase: A Multienzyme Complex for Deoxyribonucleotide Synthesis
- IV. Is the T4 dNTP Synthetase Complex Linked to DNA Replication Machinery?
- V. Enzyme Organization in Bacterial Cells
- VI. Organization of dNTP Synthesis in Eukaryotic Cells
- VII. General Discussion
- References
- Chapter 7. Identification and Characterization of Novel Substrates for Protein Tyrosine Kinases
- I. Detection of Phosphotyrosine-containing Proteins
- II. Receptor Protein Tyrosine Kinases
- III. Oncogenic Protein Tyrosine Kinases
- IV. Novel Strategies for the Identification of Substrates
- V. Tyrosine Phosphorylation: Molecular Consequences
- References
- Index
