Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 22. May 1992
291 pages
978-0-08-086330-6 (ISBN)
Description
Progress in Nucleic Acid Research and Molecular Biology
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Waldo E. Cohn | Kivie Moldave
Progress in Nucleic Acid Research and Molecular Biology: v. 42
Book
01/1992
Academic Press
€94.87
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Content
- Front Cover
- Progress in Nucleic Acid Research and Molecular Biology, Volume 42
- Copyright Page
- Contents
- Abbreviations and Symbols
- Some Articles Planned for Future Volumes
- Chapter 1. The Trp Repressor, A Ligand-Activated Regulatory Protein
- I. Early (Pre-cloning) Research on the Trp Repressor, 1959-1980
- II. The Molecular Cloning of trpR+ DNA Opened the Floodgates to Structure-Function Analysis
- III. Nucleotide Sequence of trpR DNA
- IV. Autogenous Transcriptional Regulation of the trpR Gene
- V. Signal Strength of the trpR Promoter Relative to Other s70 Promoters of E. coli
- VI. Translation of trpR mRNA and the Effect of Temperature on Regulation in the trp System
- VII. The Primary Amino-acid Sequence of the Trp Repressor: General Overview
- VIII. Engineered Systems for Overproduction of the Trp Repressor
- Protein Purification Schemes
- IX. Interaction of Tryptophan and Its Analogs with the Trp Repressor
- Effects of Ligand Binding on Operator Affinity
- X. Operator Targets Recognized by the Trp Holorepressor
- XI. Structural Alterations in Trp Repressor Generated by Mutation or Proteolysis
- XII. The Trp Repressor as a Prototypical Member of Helix-turn-helix Family of DNA-Binding Proteins
- XIII. Concluding Comments and Perspectives for Future Research on the Trp Repressor
- References
- Chapter 2. lmmunochemical Analyses of Nucleic Acids
- I. Sources and Assays of Antibodies to Nucleic Acids
- II. Antibodies to B-DNA
- III. Antibodies to Single-stranded DNA
- IV. Antibodies to Z-DNA
- V. Variants of Double-stranded DNA: Poly(dA)·poly(dT) and "Bent" DNA
- VI. Triplex DNA
- VII. Antibodies to RNA·DNA
- VIII. Branched-chain Ribonucleic Acid
- IX. Cruciform DNA
- X. Antibodies to Modified Nucleosides and Nucleotides: Bromodeoxyuridine
- XI. Antibodies to Alkylated Nucleic Acids
- XII. Summary and Future Prospects
- References
- Chapter 3. Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression
- I. Oligonucleotides as Informational Drugs
- II. Phosphorothioate Oligodeoxynucleotides
- III. Inhibition of Translation in Cell-free Systems
- IV. Cellular Uptake
- V. Oncogene Inhibition
- VI. Other Oligodeoxynucleotide Analogs
- VII. Other Approaches
- VIII. Conclusion
- References
- Chapter 4. 5,6-Dihydropyrimidine Adducts in the Reactions and Interactions of Pyrimidines with Proteins
- I. Approaches to Detect Michael Adducts of Pyrimidines
- II. Enzyme Systems That Form Michael Adducts
- References
- Note Added in Proof
- Chapter 5. RNA Replication of Plant Viruses Containing an RNA Genome
- I. Overview
- II. Replication of Brome Mosaic Virus RNA
- III. Replication of Cowpea Chlorotic Mottle Virus RNA
- IV. Replication of Cucumber Mosaic Virus RNA
- V. Replication of Alfalfa Mosaic Virus RNA
- VI. Replication of Turnip Yellow Mosaic Virus RNA
- VII. Replication of Tobacco Mosaic Virus RNA
- VIII. Replication of Cowpea Mosaic Virus RNA
- IX. Replication of Velvet Tobacco Mottle Virus RNA
- X. Discussion
- References
- Chapter 6. lntron Splicing and Intron-mediated Enhanced Expression in Monocots
- I. Introns and Perspective
- II. Intron-mediated Enhanced Expression: Historical Perspective
- III. RNA Transport
- IV. Other Observations
- V. Concluding Remarks
- References
- Chapter 7. De Novo Purine Nucleotide Biosynthesis
- I. De Novo Purine Nucleotide Biosynthesis in Prokaryotes
- II. De Novo Purine Nucleotide Synthesis in Vertebrates
- III. Summary and Perspective
- References
- Index
