Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 9. November 1990
357 pages
978-0-08-086327-6 (ISBN)
Description
Progress in Nucleic Acid Research and Molecular Biology
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Waldo E. Cohn | Kivie Moldave
Progress in Nucleic Acid Research and Molecular Biology: v. 39
Book
09/1990
Academic Press
€94.87
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Content
- Cover
- Contents
- Abbreviations and Symbols
- Some Articles Planned for Future Volumes
- Chapter 1. DNA-Protein Interactions: The Use of Synthetic Oligo- and Polynucleotides for Studying Single-stranded-DNA-binding Proteins and Restriction Endonucleases
- I. Nonspecific DNA-Protein Complexes: Structural Studies in the System: fl Gene-5 Protein-Oligo(poly)nucleotides
- II. Specific Protein-Nucleic Acid Interactions: Restriction Endonucleases EcoRII, Mval, and SsoII Studied with the Aid of Synthetic Substrates
- III. Mechanism of Cleavage of DNA Duplexes by Endonucleases EcoRII, Mval, and SsoII
- IV. Conclusion
- References
- Chapter 2. A Tale of Two Enzymes, Deoxycytidylate Deaminase and Thymidylate Synthase
- I. Deoxycytidylate Deaminase: Historical Perspective
- II. Thymidylate Synthase: Historical Perspective
- III. Concluding Remarks
- References
- Chapter 3. Stable DNA Loops in Vivo and in Vitro: Roles in Gene Regulation at a Distance and in Biophysical Characterization of DNA
- I. Historical Perspective
- II. DNA Cyclization as a Model for Looping
- III. Survey of Some Regulatory Systems in Which Stable DNA Loops Are Implicated in Action-at-a-Distance
- IV. Interpretation of Length Dependence of DNA Looping
- V. The Local Concentration Model and Topological Models for Regulatory Effects Involving DNA Looping
- VI. Conclusions
- References
- Chapter 4. Mitochondrial Aminoacyl-tRNA Synthetases
- I. Genetic System of Yeast Mitochondria
- II. Mitochondrial Aminoacyl-tRNA Synthetases
- III. Cloning of the Genes for Mitochondrial Aminoacyl-tRNA Synthetases
- IV. Threonyl-tRNA Synthetases of Yeast Mitochondria
- V. Degree of Sequence Conservation between Yeast Mitochondrial, Yeast Cytoplasmic, and Prokayotic Aminoacyl-tRNA Synthetases
- VI. Homologous Proteins within the Aminoacyl-tRNA Synthetase Family
- VII. Catalytic Sites of Aminoacyl-tRNA Synthetases
- References
- Chapter 5. Ribosomal Frameshifting from-2 to +50 Nucleotides
- I. Perspectives
- II. Exploration of the Effects of Simple Sequence Context on Reading-frame Alignment
- III. Further Observations on the Context of High-level Frameshifts
- References
- Chapter 6. Inaccuracy and the Recognition of tRNA
- I. Mischarging Mutants of GlnRS
- II. Mischarging by Overproduction of Wild-type GlnRS
- III. Mischarging of Mutant tRNAs by GlnRS
- IV. The Structure of the GlnRS:tRNAGln Complex as It Relates to tRNAGin Identity
- V. The Identity Elements of tRNAGin
- VI. Mischarging by Other Aminoacyl-tRNA Synthetases
- VII. Outlook
- References
- Chapter 7. Ribonucleases, tRNA Nucleotidyltransferase, and the 3' Processing of tRNA
- I. Overview: 3' Terminus of tRNA
- II. Encoding of the -C-C-A Sequence
- III. Outline of tRNA Processing
- IV. RNases Active at the 3' Terminus of tRNA and tRNA Precursors
- V. tRNA Nucleotidyltransferase
- VI. Regulation at the 3' Terminus of tRNA
- References
- Chapter 8. The Numerous Modified Nucleotides in Eukaryotic Ribosomal RNA
- I. Introduction
- II. Types and Numbers of Modified Nucleotides
- III. Locations of Modified Nucleotides in the rRNA Sequences
- IV. Diversity of Modification Sites in Relation to Local Primary Structure
- V. Modified Nucleotides in the Secondary Structure
- VI. rRNA Modification and Ribosome Maturation
- VII. Outlook
- References
- Chapter 9. Damage to DNA and Chromatin Structure from Ionizing Radiations, and the Radiation Sensitivities of Mammalian Cells
- I. Some Considerations of Single-Cell Survival Curves
- II. Mechanisms of Energy Transfer
- III. Chemical Protection and Radical Scavengers
- IV. Strand Breakage in Cellular DNA
- V. General Conclusions
- Glossary
- References
- Index
