Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 1. November 1988
309 pages
978-0-08-086323-8 (ISBN)
Description
Progress in Nucleic Acid Research and Molecular Biology
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Waldo E. Cohn | Kivie Moldave
Progress in Nucleic Acid Research and Molecular Biology: v. 35
Book
08/1988
Academic Press
€94.87
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Content
- Cover
- Contents
- Abbreviations and Symbols
- Some Articles Planned for Future Volumes
- Chapter 1. Complementary Use of Chemical Modification and Site-Directed Mutagenesis to Probe Structure-Activity Relationships in Enzymes
- I. Rationale for the Combined Use of Chemical Modification and Site-Directed Mutagenesis
- II. Examples of the Combined Use of Chemical Modification and Site-Directed Mutagenesis
- III. Conclusions
- References
- Chapter 2. Mechanisms of the Antiviral Action of Interferons
- I. Interferon Effects on Early Stages of Viral Multiplication Cycles
- II. Interferon Effects on Viral Macromolecular Synthesis
- III. Interferon Effects on Late Stages of Viral Multiplication Cycles
- IV. Cellular Messenger RNAs and Proteins Regulated by Interferon
- V. Conclusion
- References
- Chapter 3. Modulation of Cellular Genes by Oncogenes
- I. The ras Gene Family
- II. The Role of fos in Differentiation, Development, and Altered and Altered Gene Expression
- III. Modulation of Cellular Gene Expression by the Adenovirus E1A Products
- References
- Chapter 4. DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability
- I. Energy Deposition Mechanisms
- II. Amount of Damage Produced in DNA in Vivo
- III. Direct and Indirect Effects
- IV. Reaction Mechanisms
- V. Sites of Attack
- VI. Sugar Damage
- VII. Base Damage
- VIII. Singly Damaged Sites
- IX. Significance of Singly Damaged Sites
- X. Cellular Environment of DNA
- XI. Interaction of Energy Deposition Events with Nucleosomal Structures
- XII. Locally Multiply Damaged Sites
- XIII. Types of Locally Multiply Damaged Sites (LMDS)
- XIV. Locally Multiply Damaged Sites (LMDS) as Lethal Lesions
- XV. Conclusions
- References
- Chapter 5. Human Ferritin Gene Expression
- I. Isoferritins
- II. H cDNA Clones
- III. L cDNA Clones
- IV. Evolutionary Aspects
- V. Heterogeneity in H and L Subunits
- VI. Structural and Functional Relationships
- VII. H and L Genes
- VIII. Expressed H and L Genes
- IX. Other Human Genes
- X. Regulation of Expression
- References
- Chapter 6. Molecular Biology of the Insulin Receptor
- I. Cloning of the Human Insulin Receptor cDNA
- II. Mutagenesis and Expression of the Insulin Receptor
- III. Future Directions
- IV. Conclusion
- References
- Chapter 7. Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation
- I. Structural Features of 5' Noncoding Region of Eukaryotic mRNAs
- II. Cap-Binding Proteins in Translation
- III. Translational Discriminatory Activity
- IV. Control of ltanslation by Cap-Binding Proteins
- V. 24-kDa Cap-Binding Protein (eIF-4E) Genes
- VI. Conclusions and Perspectives
- References
- Chapter 8. Physical Monitoring of Meiotic and Mitotic Recombination in Yeast
- I. Meiotic Recombination in Saccharomyces
- II. Physical Monitoring of Mitotic Gene Conversion in Yeast Mitochondria
- III. Physical Monitoring of Yeast Mating-Type Switching
- IV. Physical Analysis of Other Mitotic Recombination Events
- V. Closing Thoughts
- References
- Chapter 9. Early Signals Underlying the Induction of the c-fos and c-myc Genes in Quiescent Fibroblasts: Studies with Bombesin and Other Growth Factors
- I. Early Protooncogene Expression
- II. Bombesin
- III. Protein Kinase C, Cytosolic Calcium Ion, and Cyclic Adenylate
- IV. Induction of c-fos and c-myc Protooncogenes: Significance in the Mitogenic Response
- V. Conclusions and Perspectives
- References
- Index
