Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 20. April 1971
572 pages
978-0-08-086299-6 (ISBN)
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Progress in Nucleic Acid Research and Molecular Biology
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02/1971
Academic Press
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Content
- Front Cover
- Progress in Nucleic Acid Research and Molecular Biology, Volume 11
- Copyright Page
- Contents
- List of Contributors
- Preface
- Abbreviations and Symbols
- Some Articles Planned for Future Volumes
- Chapter 1. The Induction of Interferon by Natural and Synthetic Polynucleotides
- I. Introduction
- II. The Induction of Interferon by Viruses
- III. The Induction of Interferon by Nonviral Agents
- IV. Double-Stranded RNA in Cells Infected with DNA-Containing Viruses
- V. Discussion of the Mechanism of Induction of Interferon
- References
- Chapter 2. Ribonucleic Acid Maturation in Animal Cells
- I. The Concept of Molecular Maturation
- II. Ribosomal RNA Maturation
- III. Maturation of tRSA
- IV. Other RNA Species That might Arise Through Maturation Processes
- V. Concluding Remarks
- References
- Chapter 3. Liporibonucleoprotein as an Integral Part of Animal Cell Membranes
- I. Introduction
- II. RNA Associated with Membranes
- III. RNA-Lipoprotein Complexes
- References
- Chapter 4. Uptake of Nonviral Nucleic Acids by Mammalian Cells
- I. Introduction
- II. Uptake of Labeled DNA
- III. Mechanisms of Uptake of DNA
- IV. Biochemical Effects of DNA
- V. Biological Effects of DNA
- VI. Uptake of Labeled RNA
- VII. Mechanism of Uptake of RNA
- VIII. Biochemical Effects of RNA
- IX. Biological Effects of RNA
- X. Conclusions and Outlook
- References
- Chapter 5. The Relaxed Control Phenomenon
- I. Introduction
- II. Genetics
- III. Anomalous Behavior of RCrel Mutank
- IV. Parallelism between the Genetic Relaxed Response and Phenotypic Relaxation
- V. Physiological Response of RCrel Mutants to Growth-Rate Transition
- VI. Proposed Mechanisms for the Control of RNA Synthesis
- VII. The Problem of Coordinate versus Noncoordinate Regulation
- VIII. Epilogue
- Note Added in Proof
- References
- Chapter 6. Molecular Aspects of Genetic Recombination
- I. Introduction
- II. Paradigms of Recombination
- III. The Recombination Cycle
- IV. Recombination Systems in Procaryotes
- V. DNA as a Target for the Recombination Event
- VI. Conclusion
- References
- Chapter 7. Principles and Practices of Nucleic Acid Hybridization
- I. Introduction
- II. Yield of Hybrid as a Function of Reactant Concentration
- III. Kinetics of the Hybridization Reaction
- IV. Estimating Relative Transcribing Activities of DNA Sites
- V. Quantitative Limitations of Hybridization
- VI. Use of Competitor RYA to Estimate Specificity
- VII. Hybridization of Nucleic Acids from Eucaryotic Cells
- VIII. Conclusions
- References
- Chapter 8. Recent Studies Concerning the Coding Mechanism
- I. Introduction-Present Status of the Code
- II. Role of Ribosomes
- III. Translation of Polycistronic Messenger RNA
- IV. Redundancy
- V. Intercistronic Sequences
- VI. Universality
- VII. Definition of the "Recognition Site" in tRNA Specifying Enzymatic Charging with the Correct Amino Acid
- VIII. Molecular Evolution of tRNA Molecules
- References
- Chapter 9. The Ribosomal RNA Cistrons
- I. Introduction
- II. Multiplicity of the Ribosomal Cistrons
- III. Notes on the Determination of the Multiplicity
- IV. Clustering of the Ribosomal Cistrons on the Chromosome
- V. Mapping of the Ribosomal DNA
- VI. Ribosomal DNA Satellites
- VII. The Isolation of Ribosomal DNA Sequences
- VIII. Stability of Redundancy
- IX. Evolution of the Ribosomal Cistrons
- X. Heterogeneity of the Ribosomal Cistrons
- XI. Conclusions
- References
- Chapter 10. Three-Dimensional Structure of tRNA
- I. Introduction
- II. Is There a Three-Dimensional Structure?
- III. The Cloverleaf, a Secondary Structure
- IV. Physical Evidence for a Three-Dimensional Structure
- V. Biochemical and Functional Requirements for Any Three-Dimensional Structure
- VI. Chemical Evidence for a Three-Dimensional Structure
- VII. Models
- VIII. Crystals
- References
- Chapter 11. Current Thoughts on the Replication of DNA
- I. Introduction
- II. Background
- III. Synthesizing Phosphodiester Bonds
- IV. Models of DNA Replication-Symmetry and Continuity
- V. Starting and Completing the Cycle
- References
- Chapter 12. Reaction of Aminoacyl-tRNA Synthetases with Heterologous tRNA's
- I. Introduction
- II. Isoacceptor Forms of tRNA
- III. Species Specificity
- IV. Effects of Conditions on Heterologous Reactions
- V. Hydrolysis of Val-tRNAval ( E . coli) by Synphe ( N . crassa)
- VI. Inhibition of Heterologous Reaction by Inorganic Pyrophosphate
- VII. Adaptor Function of tRNA
- VIII. Recognition Site of tRNA
- IX. Tumor-Specific tRNA's
- X. Organ and Organelle Specificity of Aminoacyl-tRNA Synthetases
- XI. Evolution of tRNA's and Aminoacyl-tRNA Synthetases
- References
- Appendix A Reaction of tRNA and Aminoacyl-tRNA Synthetases from Different Organisms
- Chapter 13. On the Recognition of tRNA by Its Aminoacyl-tRNA Ligase
- I. Introduction
- II. Chemical Modification
- III. Enzymatic Dissection
- IV. Structural Analysis of Isoacceptors
- V. What Is Recognized?
- References
- Author Index
- Subject Index
- Contents of Previous Volumes
