Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 1. January 1969
468 pages
978-0-08-086297-2 (ISBN)
Description
Progress in Nucleic Acid Research and Molecular Biology
More details
Other editions
Additional editions
Book
05/1969
Academic Press
€86.80
Article exhausted; check different version
Persons
Content
- Front Cover
- Progress in Nucleic Acid Research and Molecular Biology, Volume 9
- Copyright Page
- Contents
- List of Contributors
- Preface
- Abbreviations and Symbols
- Contents of Previous Volumes
- Some Articles Planned for Future Volumes
- Chapter 1. The Role of Conformation in Chemical Mutagenesis
- I. Introduction
- II. Chemistry of Action of Mutagens
- III. The Reactivity and Mutability of Polynucleotides
- IV. The Reactivity and Mutability of Double-Stranded Polynucleotides
- V. The Reactivity and Mutability of Protein-Encased Nucleic Acids
- VI. Conclusions
- Addendum
- References
- Chapter 2. Polarographic Techniques in Nucleic Acid Research
- I. Introduction
- II. Principles of Polarography
- III. The Behavior of Low-Molecular Weight Nucleic Acid Components
- IV. The Behavior of Deoxyribonucleic Acids
- V. The Behavior of Polyribonucleotides
- VI. Concluding Remarks
- References
- Chapter 3. RNA Polymerase and the Control of RNA Synthesis
- I. Introduction
- II. General Concepts of the Regulation of RNA Synthesis
- III. Purity and Physical Properties of RNA Polymerase Preparations
- IV. The Transcription Mechanism
- V. Selective Transcription
- VI. The Mechanism of RNA Chain Initiation
- VII. Termination Signals
- VIII. Inhibitors
- IX. Conclusions
- References
- Note Added in Proof
- Chapter 4. Radiation-Induced Alterations in the Structure of Deoxyribonucleic Acid and Their Biological Consequences
- I. Introduction
- II. Evidence Favoring the Idea That DNA Is an Important Macromolecular Target for Lethal Radiation Effects in Living Systems
- III. A General Survey of the Physical and Chemical Nature of Radiation- Induced Damage to DNA
- IV. Radiation Action on DNA Replication
- V. Radiation Effects on DNA Transcription and on the Biosynthesis of RNA
- VI. Biological Consequences Resulting from Radiation-Induced Damage to DNA
- VII. A Working Hypothesis
- References
- Chapter 5. Optical Rotatory Dispersion and Circular Dichroism of Nucleic Acids
- I. Introduction
- II. Optical Rotatory Dispersion and Circular Dichroism
- III. Mononucleosides and Mononucleotides
- IV. Oligonucleotides
- V. Synthetic Polynucleotides
- VI. DNA and RNA
- VII. Complexes of Nucleic Acids
- VIII. Visible Rotatory Dispersion
- IX. Concluding Remarks
- References
- Chapter 6. The Specificity of Molecular Hybridization in Relation to Studies on Higher Organisms
- I. Introduction
- II. Factors Affecting the Stability of the Formed Duplex
- III. Rates of Reassociation
- IV. Practical Implications of DNA with Different Repetition Rates
- V. Conclusions
- References
- Chapter 7. Quantum-Mechanical Investigations of the Electronic Structure of Nucleic Acids and Their Constituents
- I. Introduction
- II. Types of Calculation
- III. Schematic Description of the Methods of Calculation
- IV. Problems Investigated
- V. Electronic Properties of the Purine and Pyrimidine Bases
- VI. Interbase Interactions
- VII. Problems in Radio- and Photobiology
- VIII. Electronic Factors in Mutagenesis
- IX. Conclusion
- References
- Chapter 8. The Chemical Modification of Nucleic Acids
- I. Introduction
- II. Possibilities of Chemical Modification in the Study of the Primary and Secondary Structures of Nucleic Acids
- III. Importance of the Chemical Modification Methods for Studies of Nucleic Acid Function
- IV. Reactions Used for the Chemical Modification of Nucleic Acids
- V. Modification of the Uracil Nucleus with Hydroxylamine
- VI. Modification of the Cytosine Nucleus with Hydroxylamine
- References
- Author Index
- Subject Index
